Professor, Internal Medicine, Yale University School of Medicine
Nephrology
Dr. Robert L. Safirstein, MD
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Robert Safirstein practices Nephrology. He went to Mount Sinai School of Medicine. Robert L. Safirstein is a published MD. He has 77 papers published. The most current publication "Mechanisms of renal repair and survival following acute injury."
Publications
- Cdk2-dependent phosphorylation of p21 regulates the role of Cdk2 in cisplatin cytotoxicity.
- Am I my brother's keeper?: fratricide in the kidney.
- Protection of cisplatin cytotoxicity by an inactive cyclin-dependent kinase.
- Chronic kidney disease and GWAS: "the proper study of mankind is man".
- The cell cycle and acute kidney injury.
- Deletion of LOX-1 attenuates renal injury following angiotensin II infusion.
- Thomas E. Andreoli: a personal memorial.
- p66shc inhibits pro-survival epidermal growth factor receptor/ERK signaling during severe oxidative stress in mouse renal proximal tubule cells.
- Restoration of CREB function ameliorates cisplatin cytotoxicity in renal tubular cells.
- Involvement of the CDK2-E2F1 pathway in cisplatin cytotoxicity in vitro and in vivo.
- Dependence of cisplatin-induced cell death in vitro and in vivo on cyclin-dependent kinase 2.
- CREB mediates ERK-induced survival of mouse renal tubular cells after oxidant stress.
- Identification of the functional domain of p21(WAF1/CIP1) that protects cells from cisplatin cytotoxicity.
- Acute renal failure: from renal physiology to the renal transcriptome.
- Cisplatin-induced cell death is EGFR/src/ERK signaling dependent in mouse proximal tubule cells.
- Activation of ERK or inhibition of JNK ameliorates H(2)O(2) cytotoxicity in mouse renal proximal tubule cells.
- Protection of renal cells from cisplatin toxicity by cell cycle inhibitors.
- Cell cycle regulation: repair and regeneration in acute renal failure.
- Monocyte chemoattractant protein-1 expression correlates with monocyte infiltration in the post-ischemic kidney.
- Coordination of the cell cycle is an important determinant of the syndrome of acute renal failure.
- Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer.
- Regulation of caspase-3 and -9 activation in oxidant stress to RTE by forkhead transcription factors, Bcl-2 proteins, and MAP kinases.
- Cyclosporin induces renal proto-oncogene RNA message and increased transforming growth factor-beta prior to renal fibrosis: Modification by calcium channel blockade in...
- Positive effect of the induction of p21WAF1/CIP1 on the course of ischemic acute renal failure.
- Endothelin: the yin and yang of ischemic acute renal failure.
- How cells die counts.
- Acetylcysteine and nephrotoxic effects of radiographic contrast agents--a new use for an old drug.
- Renal regeneration: reiterating a developmental paradigm.
- The lack of a functional p21(WAF1/CIP1) gene ameliorates progression to chronic renal failure.
- Decreased abundance of collecting duct aquaporins in post-ischemic renal failure in rats.
- MAPK activation determines renal epithelial cell survival during oxidative injury.
- Cell cycle events during renal injury.
- Lessons learned from ischemic and cisplatin-induced nephrotoxicity in animals.
- Urinary biomarkers: roles in risk assessment to environmental and occupational nephrotoxins: monitoring of effects and evaluation of mechanisms of toxicity.
- Expression of the polymeric immunoglobulin receptor and excretion of secretory IgA in the postischemic kidney.
- Mechanisms of renal repair and survival following acute injury.
- Regulation of the polymeric immunoglobulin receptor by water intake and vasopressin in the rat kidney.
- Induction of p21WAF1/CIP1/SDI1 in kidney tubule cells affects the course of cisplatin-induced acute renal failure.
- p38 kinase activity is essential for osmotic induction of mRNAs for HSP70 and transporter for organic solute betaine in Madin-Darby canine kidney cells.
- Urinary biomarkers to detect significant effects of environmental and occupational exposure to nephrotoxins. VI. Future research needs.
- Renal stress response and acute renal failure.
- N-acetyl cysteine ameliorates ischemic renal failure.
- The p53-independent activation of transcription of p21 WAF1/CIP1/SDI1 after acute renal failure.
- DNA synthesis is dissociated from the immediate-early gene response in the post-ischemic kidney.
- Gene expression in nephrotoxic and ischemic acute renal failure.
- Regulation of transcription by the rat EGF gene promoter in normal and ischemic murine kidney cells.
- Cisplatin nephrotoxicity in rats: defect in papillary hypertonicity.
- Inhibition of amino acid transport by cis-diamminedichloroplatinum(II) derivatives in L1210 murine leukemia cells.
- Mutagenic activity and identification of excreted platinum in human and rat urine and rat plasma after administration of cisplatin.
- Cortical and papillary absorptive defects in gentamicin nephrotoxicity.
- Re: R. H. Earhart et al. Improvement in the therapeutic index of cisplatin (NSC 119875) by pharmacologically induced chloruresis in the rat.
- Uptake and metabolism of cisplatin by rat kidney.
- The effect of 2 hours of complete unilateral ureteral obstruction on tubuloglomerular feedback control.
- Urinary ligandin in renal tubular cell injury.
- Effects of an NH4Cl-induced metabolic acidosis on salt and water reabsorption in dog kidney.
- Effects of metabolic acidosis on proximal tubule ion reabsorption in dog kidney.
- Reduced renal blood flow in early cisplatin-induced acute renal failure in the rat.
- Urinary glutathione-S-transferase in cisplatin nephrotoxicity in the rat.
- The role of prostaglandins in early polyuria induced by cisplatin in the rat.
- Cisplatin nephrotoxicity: insights into mechanism.
- Cisplatin nephrotoxicity.
- Effect of aspirin on experimental diabetic nephropathy.
- Effects of doxorubicin and cisplatin on multicellular tumor spheroids from human lung cancer.
- Allospecific DR gene expression on the human thyroid cell.
- Glomerular hemodynamics in cyclosporine nephrotoxicity following uninephrectomy.
- Reduced renal prepro-epidermal growth factor mRNA and decreased EGF excretion in ARF.
- Changes in gene expression after temporary renal ischemia.
- In vivo and in vitro inhibition of JE gene expression by glucocorticoids.
- A hepatorenal depressor reflex: a possible clue to the pathogenesis of the hepatorenal syndrome.
- Thyrotropin receptor autoantibodies induce human thyroid cell growth and c-fos activation.
- Expression of cytokine-like genes JE and KC is increased during renal ischemia.
- Ureteral obstruction decreases renal prepro-epidermal growth factor and Tamm-Horsfall expression.
- Cloning and sequencing of the rat preproepidermal growth factor cDNA: comparison with mouse and human sequences.
- Mild oxidative stress: cellular mode of mitogenic effect.
- STAT3 attenuates EGFR-mediated ERK activation and cell survival during oxidant stress in mouse proximal tubular cells.
- Metabolomic study of cisplatin-induced nephrotoxicity.
Schools
University of Cincinnati Main Campus
New York Presbyterian Hospital
Mt Sinai Hospital
Usphs
Yale University School Of Med
Doctors Specialties
- Internal Medicine
- Nephrology
Accepted Insurances
- Blue Cross Blue Shield
- CHAMPVA
- Cigna
- Commercial Insurance Company
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- United Healthcare
Education
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Mount Sinai School of Medicine -
New York Presbyterian Hospital - Columbia Campus -
University of Cincinnati College of Medicine
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