Professor, Microbiology, Perelman School of Medicine
Pathology
Dr. Robert W. Doms, MD
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Robert W. Doms is an expert in the field of Pathology. He attended Yale University School of Medicine. Yale University School of Medicine is a top medical university. Yale University School of Medicine is ranked 7/57 in Research/PrimaryCare. He over the years received 1 awards: "Elected Member". Robert W. Doms has written publications. He has 99 publications published with PubMed. The lastest publication is: 'A haploid genetic screen identifies heparan sulfate proteoglycans supporting Rift Valley fever virus infection.'
Publications
- A haploid genetic screen identifies heparan sulfate proteoglycans supporting Rift Valley fever virus infection.
- Antibodies elicited by yeast glycoproteins recognize HIV-1 virions and potently neutralize virions with high mannose N-glycans.
- The major cellular sterol regulatory pathway is required for andes virus infection.
- Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection.
- Quantitative Phosphoproteomics Reveals Extensive Cellular Reprogramming during HIV-1 Entry.
- Phenotypic properties of transmitted founder HIV-1.
- Transmitted/founder and chronic HIV-1 envelope proteins are distinguished by differential utilization of CCR5.
- HIV: Cell Binding and Entry.
- Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7.
- Efficient production of Hantaan and Puumala pseudovirions for viral tropism and neutralization studies.
- Novel Approaches to Inhibit HIV Entry.
- Primary Infection by a Human Immunodeficiency Virus with Atypical Coreceptor Tropism.
- Phenotypic and Immunologic Comparison of Clade B Transmitted/Founder and Chronic HIV-1 Envelope Glycoproteins.
- Fusing HIV and Chemokine Receptors.
- Engineering HIV-Resistant Human CD4+ T Cells with CXCR4-Specific Zinc-Finger Nucleases.
- Quantitative Phosphoproteomics of CXCL12 (SDF-1) Signaling.
- Yeast-elicited cross-reactive antibodies to HIV Env glycans efficiently neutralize virions expressing exclusively high-mannose N-linked glycans.
- A maraviroc-resistant HIV-1 with narrow cross-resistance to other CCR5 antagonists depends on both N-terminal and extracellular loop domains of drug-bound CCR5.
- Immunology. Prime, boost, and broaden.
- HIV-1 resistance to CCR5 antagonists associated with highly efficient use of CCR5 and altered tropism on primary CD4+ T cells.
- Rift valley fever virus infection of human cells and insect hosts is promoted by protein kinase C epsilon.
- HIV type 1 from a patient with baseline resistance to CCR5 antagonists uses drug-bound receptor for entry.
- Adaptive mutations in a human immunodeficiency virus type 1 envelope protein with a truncated V3 loop restore function by improving interactions with CD4.
- Inefficient entry of vicriviroc-resistant HIV-1 via the inhibitor-CCR5 complex at low cell surface CCR5 densities.
- A yeast glycoprotein shows high-affinity binding to the broadly neutralizing human immunodeficiency virus antibody 2G12 and inhibits gp120 interactions with 2G12 and D...
- Enhanced exposure of the CD4-binding site to neutralizing antibodies by structural design of a membrane-anchored human immunodeficiency virus type 1 gp120 domain.
- HR-2 mutations in human immunodeficiency virus type 1 gp41 restore fusion kinetics delayed by HR-1 mutations that cause clinical resistance to enfuvirtide.
- Baseline resistance of primary human immunodeficiency virus type 1 strains to the CXCR4 inhibitor AMD3100.
- An engineered Saccharomyces cerevisiae strain binds the broadly neutralizing human immunodeficiency virus type 1 antibody 2G12 and elicits mannose-specific gp120-bindi...
- N-terminal substitutions in HIV-1 gp41 reduce the expression of non-trimeric envelope glycoproteins on the virus.
- Focused dampening of antibody response to the immunodominant variable loops by engineered soluble gp140.
- Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectin.
- Replication-competent variants of human immunodeficiency virus type 2 lacking the V3 loop exhibit resistance to chemokine receptor antagonists.
- V3 loop truncations in HIV-1 envelope impart resistance to coreceptor inhibitors and enhanced sensitivity to neutralizing antibodies.
- Identification of a novel C-terminal cleavage of Crimean-Congo hemorrhagic fever virus PreGN that leads to generation of an NSM protein.
- Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors.
- A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivo.
- Clinical resistance to enfuvirtide does not affect susceptibility of human immunodeficiency virus type 1 to other classes of entry inhibitors.
- The neutralizing antibody response against West Nile virus in naturally infected horses.
- Development and characterization of a Rift Valley fever virus cell-cell fusion assay using alphavirus replicon vectors.
- The location of asparagine-linked glycans on West Nile virions controls their interactions with CD209 (dendritic cell-specific ICAM-3 grabbing nonintegrin).
- A plea for justice for jailed medical workers.
- Functional impact of HIV coreceptor-binding site mutations.
- A rapid and quantitative assay for measuring antibody-mediated neutralization of West Nile virus infection.
- West Nile virus discriminates between DC-SIGN and DC-SIGNR for cellular attachment and infection.
- Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8.
- N-linked glycosylation of west nile virus envelope proteins influences particle assembly and infectivity.
- Comparing antigenicity and immunogenicity of engineered gp120.
- Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo.
- Characterization of neutralizing antibodies to West Nile virus.
- Cellular localization and antigenic characterization of crimean-congo hemorrhagic fever virus glycoproteins.
- Enfuvirtide resistance mutations: impact on human immunodeficiency virus envelope function, entry inhibitor sensitivity, and virus neutralization.
- An infectious West Nile virus that expresses a GFP reporter gene.
- BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo.
- Unwelcome guests with master keys: how HIV enters cells and how it can be stopped.
- Determinants within gp120 and gp41 contribute to CD4 independence of SIV Envs.
- Viral entry denied.
- Modulation of Env content in virions of simian immunodeficiency virus: correlation with cell surface expression and virion infectivity.
- Impact of mutations in the coreceptor binding site on human immunodeficiency virus type 1 fusion, infection, and entry inhibitor sensitivity.
- HIV transmission: closing all the doors.
- Amino acid 324 in the simian immunodeficiency virus SIVmac V3 loop can confer CD4 independence and modulate the interaction with CCR5 and alternative coreceptors.
- Qualitative T-helper responses to multiple viral antigens correlate with vaccine-induced immunity to simian/human immunodeficiency virus infection.
- Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation.
- HIV vaccine design and the neutralizing antibody problem.
- Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex.
- Public health. A sound rationale needed for phase III HIV-1 vaccine trials.
- Use of a small molecule CCR5 inhibitor in macaques to treat simian immunodeficiency virus infection or prevent simian-human immunodeficiency virus infection.
- Evolution of coreceptor use and CD4-independence in envelope clones derived from SIVsm-infected macaques.
- Distinct presenilin-dependent and presenilin-independent gamma-secretases are responsible for total cellular Abeta production.
- Structure and function of CC-chemokine receptor 5 homologues derived from representative primate species and subspecies of the taxonomic suborders Prosimii and Anthrop...
- The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex.
- Mutations in the C3 region of human and simian immunodeficiency virus envelope have differential effects on viral infectivity, replication, and CD4-dependency.
- The entry of entry inhibitors: a fusion of science and medicine.
- Unique pattern of convergent envelope evolution in simian immunodeficiency virus-infected rapid progressor macaques: association with CD4-independent usage of CCR5.
- The chemokine stromal cell-derived factor-1 promotes the survival of embryonic retinal ganglion cells.
- Membrane topology of gamma-secretase component PEN-2.
- Endoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation.
- Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR.
- The core domain of chemokines binds CCR5 extracellular domains while their amino terminus interacts with the transmembrane helix bundle.
- Secretion and intracellular generation of truncated Abeta in beta-site amyloid-beta precursor protein-cleaving enzyme expressing human neurons.
- DC-SIGN and DC-SIGNR bind ebola glycoproteins and enhance infection of macrophages and endothelial cells.
- Identification of gp120 binding sites on CXCR4 by using CD4-independent human immunodeficiency virus type 2 Env proteins.
- Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR.
- Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics.
- Diversity of receptors binding HIV on dendritic cell subsets.
- Quantitative expression and virus transmission analysis of DC-SIGN on monocyte-derived dendritic cells.
- Presenilins are not required for A beta 42 production in the early secretory pathway.
- HIV entry: are all receptors created equal?
- Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain.
- AIDS models: microbicides could learn from vaccines.
- Hemofiltrate CC chemokine 1[9-74] causes effective internalization of CCR5 and is a potent inhibitor of R5-tropic human immunodeficiency virus type 1 strains in primar...
- Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression.
- Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro.
- CD4 independence of simian immunodeficiency virus Envs is associated with macrophage tropism, neutralization sensitivity, and attenuated pathogenicity.
- A replication-competent, neutralization-sensitive variant of simian immunodeficiency virus lacking 100 amino acids of envelope.
- Truncation of the cytoplasmic domain induces exposure of conserved regions in the ectodomain of human immunodeficiency virus type 1 envelope protein.
- Expression of DC-SIGN by dendritic cells of intestinal and genital mucosae in humans and rhesus macaques.
- Gene therapy targeting HIV entry.
Schools
Yale University
Doctors Specialties
- Anatomic Pathology
- Pathology
Accepted Insurances
Awards
- Elected Member
Education
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National Institutes of Health Clinical Center -
University of Pennsylvania Health System -
Yale University School of Medicine
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