Physician
Family Medicine
Dr. Roberta J. Edwards, MD
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Roberta J. Edwards, MD is an expert in the field of Family Medicine. He studied medicine at University of Minnesota Medical School. University of Minnesota Medical School has a rank of 40 in research and a 10 in primary care Roberta Edwards is also published. He has 58 publications published. The lastest publication: "Elevated levels of neutrophil gelatinase-associated lipocalin in bile from patients with malignant pancreatobiliary disease.'
Publications
- Associations between human liver and kidney cadmium content and immunochemically detected CYP4A11 apoprotein.
- Expression of P450 enzymes in rat whole skin and cultured epidermal keratinocytes.
- Potential for early involvement of CYP isoforms in aspects of human cadmium toxicity.
- Induction of cytochrome P450 enzymes in cultured precision-cut human liver slices.
- Adduction of the chloroform metabolite phosgene to lysine residues of human histone H2B.
- Cytochrome P-4503A1 catalyzes the formation of MA1 from territrem a in liver microsomes of 7-week-old female Wistar rats.
- Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism.
- Immunohistochemical demonstration of the expression of CYP2E1 in human breast tumour and non-tumour tissues.
- Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems.
- A strategy for investigating the CYP superfamily using targeted antibodies is a paradigm for functional genomic studies.
- Expression of CYP3A4 in human breast tumour and non-tumour tissues.
- Urinary N2-(2''-deoxyguanosin-8-yl)PhIP as a biomarker for PhIP exposure.
- alpha-Tropomyosin mutations Asp(175)Asn and Glu(180)Gly affect cardiac function in transgenic rats in different ways.
- Regulation of phase I and phase II steroid metabolism enzymes by PPAR alpha activators.
- Metabolism of territrem B and C in liver microsomes from 14-wk-old Wistar rats is catalyzed by cytochrome P-450 3A.
- Genetic and other sources of variation in the activity of serum paraoxonase/diazoxonase in humans: consequences for risk from exposure to diazinon.
- Renal and hepatic accumulation of cadmium and lead in the expression of CYP4F2 and CYP2E1.
- CYP3A7 protein expression is high in a fraction of adult human livers and partially associated with the CYP3A7*1C allele.
- Specific C-terminal cleavage and inactivation of interleukin-8 by invasive disease isolates of Streptococcus pyogenes.
- Profile of territrem metabolism and cytochrome P-450 3A expression in liver microsomes from Wistar rats of both genders as a function of age.
- Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice.
- Territrems B and C metabolism in human liver microsomes: major role of CYP3A4 and CYP3A5.
- The sources of parenchymal regeneration after chronic hepatocellular liver injury in mice.
- Identification of plasma protein biomarkers associated with idiopathic pulmonary arterial hypertension.
- Kidney dysfunction and hypertension: role for cadmium, p450 and heme oxygenases?
- Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance.
- Targeting antipeptide antibodies toward cytochrome P450 enzymes.
- Identification of estrogen-responsive proteins in MCF-7 human breast cancer cells using label-free quantitative proteomics.
- Proteomic analysis of human breast cell lines using SELDI-TOF MS shows that mixtures of estrogenic compounds exhibit simple similar action (concentration additivity).
- Interindividual variation in relative CYP1A2/3A4 phenotype influences susceptibility of clozapine oxidation to cytochrome P450-specific inhibition in human hepatic mic...
- Impact of immunization against SpyCEP during invasive disease with two streptococcal species: Streptococcus pyogenes and Streptococcus equi.
- Increased expression of histone proteins during estrogen-mediated cell proliferation.
- Emerging role of the interleukin-8 cleaving enzyme SpyCEP in clinical Streptococcus pyogenes infection.
- In vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformation.
- Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract.
- Identification and assessment of plasma lysozyme as a putative biomarker of atherosclerosis.
- Characterization of androgen-regulated expression of CYP3A5 in human prostate.
- Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocell...
- Expression of cytochromes P450 3A and P-glycoprotein in human large intestine in paired tumour and normal samples.
- C-terminal antibodies (CTAbs): a simple and broadly applicable approach for the rapid generation of protein-specific antibodies with predefined specificity.
- Impaired irinotecan biotransformation in hepatic microsomal fractions from patients with chronic liver disease.
- Proteomic analysis of lung tissues from patients with pulmonary arterial hypertension.
- Elevated levels of neutrophil gelatinase-associated lipocalin in bile from patients with malignant pancreatobiliary disease.
- Cloning and characterization of a theta class glutathione transferase from the potato pathogen Phytophthora infestans.
- Influence of hormone replacement therapy on tamoxifen-induced vasomotor symptoms.
- Assessment and modeling of the toxicity of organic chemicals to Chlorella vulgaris: development of a novel database.
- Increasing attendance at colorectal cancer screening: testing the efficacy of a mailed, psychoeducational intervention in a community sample of older adults.
- Uptake of population-based flexible sigmoidoscopy screening for colorectal cancer: a nurse-led feasibility study.
- Whole proteome analysis of post-translational modifications: applications of mass-spectrometry for proteogenomic annotation.
- Flexible sigmoidoscopy screening for colorectal cancer: uptake in a population-based pilot programme.
- Surrogate endpoints for cancer screening trials: general principles and an illustration using the UK Flexible Sigmoidoscopy Screening Trial.
- Functional divergence in the glutathione transferase superfamily in plants. Identification of two classes with putative functions in redox homeostasis in Arabidopsis t...
- Redox regulation of a soybean tyrosine-specific protein phosphatase.
- Roles for stress-inducible lambda glutathione transferases in flavonoid metabolism in plants as identified by ligand fishing.
- Fluorescence quenched quinone methide based activity probes--a cautionary tale.
- Cloning, characterization and regulation of a family of phi class glutathione transferases from wheat.
- Cloning and characterization of an S-formylglutathione hydrolase from Arabidopsis thaliana.
Schools
University of Mn Med Sch
St Francis Hospital
Doctors Specialties
- Family Medicine
Accepted Insurances
- Medicare MCR
- Ucare
Education
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University of Minnesota Medical School
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