Senior Investigator, National Heart, Lung, and Blood Institute, NIH
Neonat/Perinatology
Dr. Rodney L. Levine, MD
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Rodney Levine practices Neonat/Perinatology. He attended Stanford University School of Medicine. Stanford University School of Medicine is a top medical university. Stanford University School of Medicine has a rank of 2 in research and a 25 in primary care He over the years received 21 awards: "Fellow", "Award of Merit", "Norman Kretchmer Visiting Professor and Kretchmer Memorial Lecturer", "Postdoctoral Fellows Award for Research Mentoring", "The Fleming Lecturer", "Jerry Elliot Memorial Lecture", "Dorothy Dillon Eweson Lecture", "The Surgeon General's Exemplary Service Medal", "Outstanding Service Medal (NIH Director's Award) for "Fundamental contributions to an understanding of the role of metal ion catalyzed oxygen free radical damage to proteins in pathological disorders"", "Handy Memorial Lectureship", "Commendation Medal "For scientific accomplishments"", "Lubchenco Lectureship", "The Housestaff Award for Excellence in Teaching", "Young Investigator Award", "Ross Award in Research, "For his contribution to Research in Pediatrics",", "Harold K. Faber Award", "Alpha Omega Alpha", "Lloyd Dinklespiel Award to the Outstanding Graduate", "Sigma Xi Award", "Phi Lambda Upsilon" and "Phi Beta Kappa". Rodney Levine is also published. He has 100 publications published. The lastest publication: "Molecular cloning and characterization of a mitochondrial selenocysteine-containing thioredoxin reductase from rat liver.'
Publications
- Distinct oxidative cleavage and modification of bovine [Cu- Zn]-SOD by an ascorbic acid/Cu(II) system: Identification of novel copper binding site on SOD molecule.
- Nonenzymatic Conversion of ADP-Ribosylated Arginines to Ornithine Alters the Biological Activities of Human Neutrophil Peptide-1.
- Mechanism of oxidative inactivation of human presequence protease (hPreP) by hydrogen peroxide.
- Treatment with the reactive oxygen species scavenger EUK-207 reduces lung damage and increases survival during 1918 influenza virus infection in mice.
- Methionine oxidation and reduction in proteins.
- Stereospecific Oxidation of Calmodulin by Methionine Sulfoxide Reductase A.
- Response to dr. Moskovitz.
- Site-Specific Interaction between ?-Synuclein and Membranes Probed by NMR-Observed Methionine Oxidation Rates.
- Quantification of protein carbonylation.
- Regulation of the actin-activated MgATPase activity of Acanthamoeba myosin II by phosphorylation of serine 639 in motor domain loop 2.
- Methionine sulfoxide reductase contributes to meeting dietary methionine requirements.
- Myristoylated Methionine Sulfoxide Reductase A Protects the Heart from Ischemia-Reperfusion Injury.
- Methionine sulfoxide reductase A is a stereospecific methionine oxidase.
- Iron regulatory protein 2 turnover through a non-proteasomal pathway.
- Deuteration of Escherichia coli enzyme I(Ntr) alters its stability.
- Transgenic mice overexpressing methionine sulfoxide reductase A: characterization of embryonic fibroblasts.
- Dual sites of protein initiation control the localization and myristoylation of methionine sulfoxide reductase A.
- Characterization of a covalent polysulfane bridge in copper-zinc superoxide dismutase .
- Small-molecule antioxidant proteome-shields in Deinococcus radiodurans.
- Decreased levels of secretory leucoprotease inhibitor in the Pseudomonas-infected cystic fibrosis lung are due to neutrophil elastase degradation.
- ADP-ribosylation of human defensin HNP-1 results in the replacement of the modified arginine with the noncoded amino acid ornithine.
- Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span.
- Methionine in proteins defends against oxidative stress.
- Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis.
- Mitochondrial NADH fluorescence is enhanced by complex I binding.
- Metal-catalyzed oxidation of the Werner syndrome protein causes loss of catalytic activities and impaired protein-protein interactions.
- Phosphorylation of actin Tyr-53 inhibits filament nucleation and elongation and destabilizes filaments.
- ADP-ribosyltransferase-specific modification of human neutrophil peptide-1.
- Quantitation of protein on gels and blots by infrared fluorescence of Coomassie blue and Fast Green.
- Proteasomal degradation of mutant superoxide dismutases linked to amyotrophic lateral sclerosis.
- Mutation of the adenylylated tyrosine of glutamine synthetase alters its catalytic properties.
- Molecular determinants of S-glutathionylation of carbonic anhydrase 3.
- Commentary on "Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death" by D.A. Bota, J.K. Ngo, and K.J.A...
- Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence.
- Metal-catalyzed oxidation of alpha-synuclein: helping to define the relationship between oligomers, protofibrils, and filaments.
- Oxidation of methionine residues in the prion protein by hydrogen peroxide.
- Carbonic anhydrase III is not required in the mouse for normal growth, development, and life span.
- Identification of a heme-sensing domain in iron regulatory protein 2.
- Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells.
- High urea and NaCl carbonylate proteins in renal cells in culture and in vivo, and high urea causes 8-oxoguanine lesions in their DNA.
- Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice.
- Oxidation of methionine residues of proteins: biological consequences.
- The role of endogenous heme synthesis and degradation domain cysteines in cellular iron-dependent degradation of IRP2.
- Inactivation of human beta-defensins 2 and 3 by elastolytic cathepsins.
- Group B streptococcal phospholipid causes pulmonary hypertension.
- Iron regulatory protein 2 as iron sensor. Iron-dependent oxidative modification of cysteine.
- Direct detection of potential selenium delivery proteins by using an Escherichia coli strain unable to incorporate selenium from selenite into proteins.
- ADP ribosylation of human neutrophil peptide-1 regulates its biological properties.
- Carbonyl modified proteins in cellular regulation, aging, and disease.
- Assessment of skin carbonyl content as a noninvasive measure of biological age.
- Reversible oxidation of HIV-2 protease.
- Detection and affinity purification of oxidant-sensitive proteins using biotinylated glutathione ethyl ester.
- Protein oxidation.
- Recent advances in the analysis of oxidized proteins.
- Carbonic anhydrase III. Oxidative modification in vivo and loss of phosphatase activity during aging.
- Differential susceptibility of plasma proteins to oxidative modification: examination by western blot immunoassay.
- Derivatization of gamma-glutamyl semialdehyde residues in oxidized proteins by fluoresceinamine.
- Hydrogen peroxide mediates the oxidative inactivation of enzymes following the switch from anaerobic to aerobic metabolism in Klebsiella pneumoniae.
- Proteolysis induced by metal-catalyzed oxidation.
- Forward and reverse selection for longevity in Drosophila is characterized by alteration of antioxidant gene expression and oxidative damage patterns.
- MDP-1: A novel eukaryotic magnesium-dependent phosphatase.
- Oxidative modification of proteins during aging.
- Age-related decline of rat liver multicatalytic proteinase activity and protection from oxidative inactivation by heat-shock protein 90.
- Free radical-mediated oxidation of free amino acids and amino acid residues in proteins.
- Effects of aging and hyperoxia on oxidative damage to cytochrome c in the housefly, Musca domestica.
- Oxidation of cellular proteins by beta-amyloid peptide.
- Implication of protein oxidation in protein turnover, aging, and oxygen toxicity.
- Copper inhibits the protease from human immunodeficiency virus 1 by both cysteine-dependent and cysteine-independent mechanisms.
- Determination of 2-oxohistidine by amino acid analysis.
- Oxidative stress and aging.
- Ischemia: from acidosis to oxidation.
- Why have cells selected reactive oxygen species to regulate cell signaling events?
- Molecular cloning and characterization of a mitochondrial selenocysteine-containing thioredoxin reductase from rat liver.
- Oxidation of proteins in neonatal lungs.
- Modification of cysteine residues in vitro and in vivo affects the immunogenicity and antigenicity of major histocompatibility complex class I-restricted viral determi...
- Selectivity of protein oxidative damage during aging in Drosophila melanogaster.
- Covalent modification of proteins by mixed-function oxidation: recognition by intracellular proteases.
- Oxidative damage during aging targets mitochondrial aconitase.
- Mixed-function oxidation of histidine residues.
- Purification of a protease from Escherichia coli with specificity for oxidized glutamine synthetase.
- Regulation of activity of carbamoyl phosphate synthetase from mouse spleen.
- Oxidative modification of glutamine synthetase: covalent and conformational changes which control susceptibility to proteolysis.
- Turnover of bacterial glutamine synthetase: oxidative inactivation precedes proteolysis.
- Neonatal jaundice.
- A difference in mortality between two strains of jaundiced rats.
- Sequence of a peptide susceptible to mixed-function oxidation. Probable cation binding site in glutamine synthetase.
- Oxidative modification of glutamine synthetase. I. Inactivation is due to loss of one histidine residue.
- Oxidative dissociation of human alpha 2-macroglobulin tetramers into dysfunctional dimers.
- Mutational analysis of the CTNNB1 and APC genes in uterine endometrioid carcinoma.
- Extrachromosomal unequal homologous recombination and gene conversion in simian kidney cells: effects of UV damage.
- Oxidative modification of glutamine synthetase. II. Characterization of the ascorbate model system.
- The AAGL classification system for laparoscopic hysterectomy. Classification committee of the American Association of Gynecologic Laparoscopists.
- Rat parotid gland amylase: evidence for alterations in an exocrine protein with increased age.
- Base hydrolysis and amino acid analysis for phosphotyrosine in proteins.
- Labeling of cysteine-containing peptides with 2-nitro-5-thiobenzoic acid.
- Conversion of carbamoyl phosphate to hydroxyurea. An assay for carbamoylphosphate synthetase.
- A multicenter study of laparoscopic management of selected cystic adnexal masses in postmenopausal women.
- Ischemic stroke associated with activated protein C resistance and aortic valvular papillary fibroelastoma.
- Quantitation of aromatic residues in proteins: model compounds for second-derivative spectroscopy.
Schools
Stanford University
Colo Med Center
Doctors Specialties
- Neonatal Medicine
- Neonat/Perinatology
Accepted Insurances
Awards
- Fellow
- Award of Merit
- Norman Kretchmer Visiting Professor and Kretchmer Memorial Lecturer
- Postdoctoral Fellows Award for Research Mentoring
- The Fleming Lecturer
- Jerry Elliot Memorial Lecture
- Dorothy Dillon Eweson Lecture
- The Surgeon General's Exemplary Service Medal
- Outstanding Service Medal (NIH Director's Award) for "Fundamental contributions to an understanding of the role of metal ion catalyzed oxygen free radical damage to proteins in pathological disorders"
- Handy Memorial Lectureship
- Commendation Medal "For scientific accomplishments"
- Lubchenco Lectureship
- The Housestaff Award for Excellence in Teaching
- Young Investigator Award
- Ross Award in Research, "For his contribution to Research in Pediatrics",
- Harold K. Faber Award
- Alpha Omega Alpha
- Lloyd Dinklespiel Award to the Outstanding Graduate
- Sigma Xi Award
- Phi Lambda Upsilon
- Phi Beta Kappa
Education
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University of Colorado -
Stanford University School of Medicine -
Stanford University
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