Lecturer on Medicine, VA, VFW Parkway WestRox
Gastroenterology
Dr. Satish K. Singh, MD
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Satish Singh works in the field of Gastroenterology. He went to Boston University School of Medicine. Boston University School of Medicine has a rank of 30 in research and a 52 in primary care He received 1 awards: "Fellow (AGAF)". Satish K. Singh is also published. He has 61 publications published. The lastest publication: "Characterization and Higher-Order Structure Assessment of an Interchain Cysteine-Based ADC: Impact of Drug Loading and Distribution on the Mechanism of Aggregation.'
Publications
- Antibody-Drug Conjugates: Design, Formulation and Physicochemical Stability.
- Subvisible (2-100 μm) particle analysis during biotherapeutic drug product development: Part 2, experience with the application of subvisible particle analysis.
- Improving Heat Transfer at the Bottom of Vials for Consistent Freeze Drying with Unidirectional Structured Ice.
- Emerging enhanced imaging technologies of the esophagus: spectroscopy, confocal laser endomicroscopy, and optical coherence tomography.
- Glucose-dependent insulinotropic polypeptide-mediated signaling pathways enhance apical PepT1 expression in Intestinal epithelial cells.
- Highly Viscous Antibody Solutions Are a Consequence of Network Formation Caused by Domain-Domain Electrostatic Complementarities: Insights from Coarse-Grained Simulati...
- Endoscopic histological assessment of colonic polyps by using elastic scattering spectroscopy.
- Concentration Dependent Viscosity of Monoclonal Antibody Solutions: Explaining Experimental Behavior in Terms of Molecular Properties.
- Elastic scattering spectroscopy as an optical marker of inflammatory bowel Disease activity and subtypes.
- Assessment of Physical Stability of an Antibody Drug Conjugate by Higher Order Structure Analysis: Impact of Thiol- Maleimide Chemistry.
- Consequences of glycan truncation on Fc structural integrity.
- Glucose-dependent insulinotropic polypeptide regulates dipeptide absorption in mouse jejunum.
- On the role of aggregation prone regions in protein evolution, stability, and enzymatic catalysis: insights from diverse analyses.
- Measuring and Modeling Hemoglobin Aggregation below the Freezing Temperature.
- The importance of heat flow direction for reproducible and homogeneous freezing of bulk protein solutions.
- Metal Ion Leachates and the Physico-Chemical Stability of Biotherapeutic Drug Products.
- Insights into the potential aggregation liabilities of the b12 Fab fragment via elevated temperature molecular dynamics.
- Impact of deglycosylation and thermal stress on conformational stability of a full length murine igG2a monoclonal antibody: observations from molecular dynamics simula...
- Frozen-state storage stability of a monoclonal antibody: Aggregation is impacted by freezing rate and solute distribution.
- Interobserver Agreement for Confocal Imaging of Ampullary Lesions: A Multicenter Single-blinded Study.
- Biotherapeutic Formulation Factors Affecting Metal Leachables from Stainless Steel Studied by Design of Experiments.
- Crystal structures of multicopper oxidase cueo bound to copper(I) and silver(I): Functional role of a methionine-rich sequence.
- Xenon Hydrate Dissociation Measurements With Model Protein Systems.
- Distinct Aggregation Mechanisms of Monoclonal Antibody Under Thermal and Freeze-Thaw Stresses Revealed by Hydrogen Exchange.
- Aggregation in protein-based biotherapeutics: Computational studies and tools to identify aggregation-prone regions.
- Impact of extractables/leachables from filters on stability of protein formulations.
- Disulfide Scrambling in IgG2 Monoclonal Antibodies: Insights from Molecular Dynamics Simulations.
- Spectral classifier design with ensemble classifiers and misclassification-rejection: application to elastic-scattering spectroscopy for detection of colonic neoplasia.
- A New Approach to Explore the Impact of Freeze-Thaw Cycling on Protein Structure: Hydrogen/Deuterium Exchange Mass Spectrometry (HX-MS).
- Coupling of aggregation and immunogenicity in biotherapeutics: T- and B-cell immune epitopes may contain aggregation-prone regions.
- Frozen state storage instability of a monoclonal antibody: aggregation as a consequence of trehalose crystallization and protein unfolding.
- INTEGRATED OPTICAL TOOLS FOR MINIMALLY INVASIVE DIAGNOSIS AND TREATMENT AT GASTROIntestinal ENDOSCOPY.
- Biologics formulation factors affecting metal leachables from stainless steel.
- Impact of product-related factors on immunogenicity of biotherapeutics.
- Effect of freezing rate and dendritic ice formation on concentration profiles of proteins frozen in cylindrical vessels.
- Comparative evaluation of disodium edetate and diethylenetriaminepentaacetic acid as iron chelators to prevent metal-catalyzed destabilization of a therapeutic monoclo...
- Mucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colon.
- An industry perspective on the monitoring of subvisible particles as a quality attribute for protein therapeutics.
- Potential aggregation-prone regions in complementarity-determining regions of antibodies and their contribution towards antigen recognition: a computational analysis.
- Impact of freezing on pH of buffered solutions and consequences for monoclonal antibody aggregation.
- Connections between genetics and clinical data: Role of MCP-1, CFTR, and SPINK-1 in the setting of acute, acute recurrent, and chronic pancreatitis.
- Optically sectioned fluorescence endomicroscopy with hybrid-illumination imaging through a flexible fiber bundle.
- Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies.
- Glucose-dependent insulinotropic polypeptide (GIP) stimulates transepithelial glucose transport.
- Analysis of changes in reflectance measurements on biological tissues subjected to different probe pressures.
- Gastrointestinal Cancer surveillance by optical sensing.
- Vacuolar H+ -ATPase B1 subunit mutations that cause inherited distal renal tubular acidosis affect proton pump assembly and trafficking in inner medullary collecting d...
- Cuprous oxidase activity of CueO from Escherichia coli.
- Keratins modulate colonocyte electrolyte transport via protein mistargeting.
- HSP72 inhibits apoptosis-inducing factor release in ATP-depleted renal epithelial cells.
- Low cost extraction and isothermal amplification of DNA for infectious diarrhea diagnosis.
- Giant left anterior descending artery aneurysm.
- Antibody structure, instability, and formulation.
- Subvisible particle counting provides a sensitive method of detecting and quantifying aggregation of monoclonal antibody caused by freeze-thawing: insights into the ro...
- Gastrin stimulates receptor-mediated proliferation of human Esophageal adenocarcinoma cells.
- Microscale sample preparation for PCR of C. difficile infected stool.
- Sample preparation module for bacterial lysis and isolation of DNA from human urine.
- Rational design of viscosity reducing mutants of a monoclonal antibody: hydrophobic versus electrostatic inter-molecular interactions.
- Characterization and Higher-Order Structure Assessment of an Interchain Cysteine-Based ADC: Impact of Drug Loading and Distribution on the Mechanism of Aggregation.
- Molecular basis of high viscosity in concentrated antibody solutions: Strategies for high concentration drug product development.
Schools
Boston University School Of Medicine
University Of Rochester Strong Mem Hospital
Yale University School Of Med
Procedures Preformed
- Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
Conditions Treated
- Anemia
- Cholecystitis and Gallstones
- Colorectal Cancer
- Diaphragmatic and-or Hiatal Hernia
- View All
Doctors Specialties
- Gastroenterology
Accepted Insurances
Awards
- Fellow (AGAF)
Education
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Yale-New Haven Hospital -
University of Rochester -
Boston University School of Medicine
Hospital
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Boston Medical Center
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