Professor, Pediatric Hematology and Oncology, Baylor College of Medicine

Pediatrics

Sharon Plon, PHD is an expert in the field of Pediatrics. She over the years received 3 awards: "America's Top Doctors", "Top Doctors:SE Texas" and "America's Top Doctors for Cancer". Doctor Sharon Plon, PHD is a published MD as well. She has 90 publications published. The latest was: Cancer genetics--survey of primary care physicians' attitudes and practices.

Publications

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• CSER and eMERGE: current and potential state of the display of genetic information in the electronic health record.
• Is Whole-Exome Sequencing an Ethically Disruptive Technology? Perspectives of Pediatric Oncologists and Parents of Pediatric Patients With Solid Tumors.
• Pediatric Cancer Genetics Research and an Evolving Preventive Ethics Approach for Return of Results after Death of the Subject.
• Family history of cancer and childhood rhabdomyosarcoma: a report from the Children's Oncology Group and the Utah Population Database.
• Germline mutations in shelterin complex genes are associated with familial glioma.
• Parent decision-making around the genetic testing of children for germline TP53 mutations.
• Molecular Findings Among Patients Referred for Clinical Whole-Exome Sequencing.
• Clinical whole-exome sequencing for the diagnosis of mendelian disorders.
• Experiences and attitudes of genome investigators regarding return of individual genetic test results.
• Returning genetic research results: study type matters.
• The practice of adult genetics: A 7-year experience from a single center.
• Statistical Analysis of Missense Mutation Classifiers.
• Incidental copy-number variants identified by routine genome testing in a clinical population.
• Outcomes of integrating genetics in management of patients with retinoblastoma.
• Clinically relevant changes in family history of cancer over time.
• Constitutional tandem duplication of 9q34 that truncates EHMT1 in a child with ganglioglioma.
• Insights into the pathogenesis and treatment of cancer from inborn errors of metabolism.
• Unifying cancer genetics.
• Prediction of missense mutation functionality depends on both the algorithm and sequence alignment employed.
• Identification of a novel C16orf57 mutation in Athabaskan patients with Poikiloderma with Neutropenia.
• Genetic testing and cancer risk management recommendations by physicians for at-risk relatives.
• Identification of genetic susceptibility to childhood cancer through analysis of genes in parallel.
• Utilizing Saccharomyces cerevisiae to identify aneuploidy and cancer susceptibility genes.
• Overexpression of ZNF342 by juxtaposition with MPO promoter/enhancer in the novel translocation t(17;19)(q23;q13.32) in pediatric acute myeloid leukemia and analysis o...
• Syndromic thrombocytopenia and predisposition to acute myelogenous leukemia caused by constitutional microdeletions on chromosome 21q.
• Clinical utility of array comparative genomic hybridization for detection of chromosomal abnormalities in pediatric acute lymphoblastic leukemia.
• Multiple tumors in a child with germ-line mutations in TP53 and PTEN.
• Generalized metabolic bone disease in Neurofibromatosis type I.
• Heterozygous screen in Saccharomyces cerevisiae identifies dosage-sensitive genes that affect chromosome stability.
• Retinoblastoma: review of current management.
• A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma.
• A phase 1 study of the proteasome inhibitor bortezomib in pediatric patients with refractory leukemia: a Children's Oncology Group study.
• Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia.
• Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response.
• Severe dysplasia in children with familial adenomatous polyposis: rare or simply overlooked?
• Inherited susceptibility for pediatric cancer.
• A homozygous mutation in MSH6 causes Turcot syndrome.
• Acute lymphoblastic leukemia in a patient with Greig cephalopolysyndactyly and interstitial deletion of chromosome 7 del(7)(p11.2 p14) involving the GLI3 and ZNFN1A1 g...
• Cancer. A risky business--assessing breast cancer risk.
• Loss of Sin3/Rpd3 histone deacetylase restores the DNA damage response in checkpoint-deficient strains of Saccharomyces cerevisiae.
• Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund-Thomson syndrome.
• Absence of RECQL4 mutations in poikiloderma with neutropenia in Navajo and non-Navajo patients.
• Primary care physicians' attitudes and practices regarding cancer genetics: a comparison of 2001 with 1996 survey results.
• Linking sister chromatid cohesion and apoptosis: role of Rad21.
• Intron-size constraint as a mutational mechanism in Rothmund-Thomson syndrome.
• Counseling the at risk patient in the BRCA1 and BRCA2 Era.
• Minichromosome maintenance protein MCM7 is a direct target of the MYCN transcription factor in neuroblastoma.
• Phenotypic manifestations of copy number variation in chromosome 16p13.11.
• The involvement of human RECQL4 in DNA double-strand break repair.
• Bortezomib interactions with chemotherapy agents in acute leukemia in vitro.
• The mutation spectrum in RECQL4 diseases.
• Differential in vitro cytotoxicity does not explain increased host toxicities from chemotherapy in Down syndrome acute lymphoblastic leukemia.
• Locus-specific databases and recommendations to strengthen their contribution to the classification of variants in cancer susceptibility genes.
• Sequence variant classification and reporting: recommendations for improving the interpretation of cancer susceptibility genetic test results.
• A robust estimator of mutation rates.
• Prevalence and clinical correlates of JAK2 mutations in Down syndrome acute lymphoblastic leukaemia.
• Nuclear import and retention domains in the amino terminus of RECQL4.
• Sensitivity of RECQL4-deficient fibroblasts from Rothmund-Thomson syndrome patients to genotoxic agents.
• CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor.
• Cyclin D and cisplatin cytotoxicity in primary neuroblastoma cell lines.
• Susceptibility to insulin-dependent diabetes mellitus maps to a locus (IDDM11) on human chromosome 14q24.3-q31.
• Screening for 185delAG in the Ashkenazim.
• Anticipation in pediatric malignancies.
• Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA.
• Design and analysis of epidemiological studies of excess cancer among children exposed to Chernobyl radionuclides.
• Cancer genetics--survey of primary care physicians' attitudes and practices.
• Growth deficiency and malnutrition in Bloom syndrome.
• Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis.
• Psychological and behavioral factors associated with colorectal cancer screening among Ashkenazim.
• Screening and clinical implications for BRCA1 and BRCA2 mutation carriers.
• Neoplasms in neurofibromatosis 1 are related to gender but not to family history of cancer.
• Psychological impact of receiving negative BRCA1 mutation test results in Ashkenazim.
• Mammography behavior after receiving a negative BRCA1 mutation test result in the Ashkenazim: a community-based study.
• FBN1 exon 2 splicing error in a patient with Marfan syndrome.
• Clinical manifestations in a cohort of 41 Rothmund-Thomson syndrome patients.
• Expression and localization of the CDC34 ubiquitin-conjugating enzyme in pediatric acute lymphoblastic leukemia.
• Cell cycle-dependent expression and nucleolar localization of hCAP-H.
• Revisiting the craniosynostosis-radial ray hypoplasia association: Baller-Gerold syndrome caused by mutations in the RECQL4 gene.
• The sequence of an adrenal specific human cDNA, pG2.
• The use of psoralen-modified DNA to probe the mechanism of enhancer action.
• Transcription of the human beta-globin gene is stimulated by an SV40 enhancer to which it is physically linked but topologically uncoupled.
• The nature of the binuclear copper site in Limulus and other hemocyanins.
• Terasaki plates streamline dideoxy sequencing.
• Abrogation of the G2 checkpoint results in differential radiosensitization of G1 checkpoint-deficient and G1 checkpoint-competent cells.
• Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast.
• Outcomes of systematic screening for optic pathway tumors in children with Neurofibromatosis Type 1.
• Unravelling immunoglobulin expression.
• Significant differences among physician specialties in management recommendations of BRCA1 mutation carriers.
• Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles.

Doctors Specialties

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• Clinical Genetics
• Pediatrics

Accepted Insurances

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Awards

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• America's Top Doctors
• Top Doctors:SE Texas
• America's Top Doctors for Cancer

Hospital

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• Baylor St. Luke's Medical Center
• Texas Children's Hospital

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