Physician
Radiology
Dr. Sidney M. Hecht, MD
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Sidney Hecht works in the field of Radiology. He researched medicine at University of Miami Miller School of Medicine. University of Miami Miller School of Medicine is ranked 45 in research and 0 in primary care medicine Sidney Hecht is also published. He has 101 publications published. The lastest publication: "Differential effects of camptothecin derivatives on topoisomerase I-mediated DNA structure modification.'
Publications
- Synthesis of fluorescent dipeptidomimetics and their ribosomal incorporation into green fluorescent protein.
- Fluorescent CD4 probe for potential HIV-1 gp120 protein detection.
- Novel Antioxidants Protect Mitochondria from the Effects of Oligomeric Amyloid Beta and Contribute to the Maintenance of Epigenome Function.
- Probing of CD4 binding pocket of HIV-1 gp120 glycoprotein using unnatural phenylalanine analogues.
- Modified Bleomycin Disaccharides Exhibiting Improved Tumor Cell Targeting.
- DNA Methylation Reduces Binding and Cleavage by Bleomycin.
- A Short DNA Sequence Confers Strong Bleomycin Binding to Hairpin DNAs.
- Tryptophan-based fluorophores for studying protein conformational changes.
- The Disaccharide Moiety of Bleomycin Facilitates Uptake by Cancer Cells.
- Cytoprotective pyridinol antioxidants as potential therapeutic agents for neurodegenerative and mitochondrial diseases.
- The Carbamoylmannose Moiety of Bleomycin Mediates Selective Tumor Cell Targeting.
- The Transcriptional Complex Between the BCL2 i-Motif and hnRNP LL Is a Molecular Switch for Control of Gene Expression That Can Be Modulated by Small Molecules.
- The Dynamic Character of the BCL2 Promoter i-Motif Provides a Mechanism for Modulation of Gene Expression by Compounds That Bind Selectively to the Alternative DNA Hai...
- Hairpin DNA sequences bound strongly by bleomycin exhibit enhanced double-strand cleavage.
- Efficient Asymmetric Synthesis of Tryptophan Analogues Having Useful Photophysical Properties.
- Fluorescent biphenyl derivatives of phenylalanine suitable for protein modification.
- A structurally simplified analogue of geldanamycin exhibits neuroprotective activity.
- Detection of Dihydrofolate Reductase Conformational Change by FRET Using Two Fluorescent Amino Acids.
- An optimized pyrimidinol multifunctional radical quencher.
- Characterization of Bleomycin-Mediated Cleavage of a Hairpin DNA Library.
- Effects of alkyl side chain modification of coenzyme Q10 on mitochondrial respiratory chain function and cytoprotection.
- Incorporation of ?-amino acids into dihydrofolate reductase by ribosomes having modifications in the peptidyltransferase center.
- Effects of cytoprotective antioxidants on lymphocytes from representative mitochondrial neurodegenerative diseases.
- Selective Tumor Cell Targeting by the Disaccharide Moiety of Bleomycin.
- Synthesis and biological activities of N-(3-carboxylpropyl)-5-amino-2-hydroxy-3-tridecyl-1,4-benzoquinone and analogues.
- Beta-cyclodextrin derivatives that inhibit anthrax lethal toxin.
- (+)-Myristinins A and D from Knema elegans, which inhibit DNA polymerase beta and cleave DNA.
- Exploring the cellular activity of camptothecin-triple-helix-forming oligonucleotide conjugates.
- Three acetylated flavonol glycosides from Forsteronia refracta that specifically inhibit p90 RSK.
- Tandemly activated tRNAs as participants in protein synthesis.
- Bioactive isomalabaricane triterpenoids from Rhabdastrella globostellata that stabilize the binding of DNA polymerase beta to DNA.
- Stereoselective synthesis of the atropisomers of myristinin B/C.
- Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK.
- Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore.
- Effects of modification of the active site tyrosine of human DNA topoisomerase I.
- Synthesis and biological evaluation of 10,11-methylenedioxy-14-azacamptothecin.
- Search for cyclodextrin-based inhibitors of anthrax toxins: synthesis, structural features, and relative activities.
- An efficient mammalian transfer RNA target for bleomycin.
- Construction of modified ribosomes for incorporation of D-amino acids into proteins.
- Investigating the "steric gate" of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by targeted insertion of unnatural amino acids.
- Site-specific incorporation of glycosylated serine and tyrosine derivatives into proteins.
- Synthesis of proteins containing modified arginine residues.
- Synthesis of bisaminoacylated pdCpAs and tandemly activated transfer RNAs.
- Structural basis for the activity of the RSK-specific inhibitor, SL0101.
- Inhibition of S. aureus alpha-hemolysin and B. anthracis lethal toxin by beta-cyclodextrin derivatives.
- Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines.
- Positional assignment of differentially substituted bisaminoacylated pdCpAs.
- Biochemical evaluation of a 108-member deglycobleomycin library: viability of a selection strategy for identifying bleomycin analogues with altered properties.
- Total synthesis of the topopyrones: a new class of topoisomerase I poisons.
- Aminoacylation of transfer RNAs with one and two amino acids.
- Inhibitors of DNA polymerase beta: activity and mechanism.
- Chemical and traditional mutagenesis of vaccinia DNA topoisomerase provides insights to cleavage site recognition and transesterification chemistry.
- A novel DNA hairpin substrate for bleomycin.
- Identification of strong DNA binding motifs for bleomycin.
- The topopyrones poison human DNA topoisomerases I and II.
- Synthesis of pdCpAs and transfer RNAs activated with derivatives of aspartic acid and cysteine.
- Modeling the reactive properties of tandemly activated tRNAs.
- Synthesis and characterization of Deltalac-acetogenins that potently inhibit mitochondrial complex I.
- Identification and cleavage site analysis of DNA sequences bound strongly by bleomycin.
- Carbohydrate dependent targeting of cancer cells by bleomycin-microbubble conjugates.
- Calothrixins, a new class of human DNA topoisomerase I poisons.
- Nucleic acids: expanding the structural and functional horizons.
- The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding pattern.
- Does oxidative stress contribute to the pathology of Friedreich's ataxia? A radical question.
- Synthesis and evaluation of verticipyrone analogues as mitochondrial complex I inhibitors.
- Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria.
- Design, synthesis, and evaluation of an α-tocopherol analogue as a mitochondrial antioxidant.
- Concise synthesis of bicyclic pyridinol antioxidants.
- Characterization of bleomycin cleavage sites in strongly bound hairpin DNAs.
- Deglycobleomycin A6 analogues modified in the methylvalerate moiety.
- Structural basis for the exceptional stability of bisaminoacylated nucleotides and transfer RNAs.
- An acetate prodrug of a pyridinol-based vitamin E analogue.
- A new strategy for the synthesis of bisaminoacylated tRNAs.
- p-Thiophenylalanine-induced DNA cleavage and religation activity of a modified vaccinia topoisomerase IB.
- One-pot regio- and stereoselective synthesis of ?'-methoxy-?-pyrones: biological evaluation as mitochondrial respiratory complex inhibitors.
- ?-Puromycin selection of modified ribosomes for in vitro incorporation of ?-amino acids.
- Design and optimization of camptothecin conjugates of triple helix-forming oligonucleotides for sequence-specific DNA cleavage by topoisomerase I.
- Specific cleavage of a DNA triple helix by FeII.bleomycin.
- bis-5-Alkylresorcinols from Panopsis rubescens that inhibit DNA polymerase beta.
- Effects of release factor 1 on in vitro protein translation and the elaboration of proteins containing unnatural amino acids.
- DNA polymerase beta inhibitors from Baeckea gunniana.
- Pentacyclic triterpenoids from Freziera sp. that inhibit DNA polymerase beta.
- Solid-phase synthesis of bleomycin group antibiotics. Elaboration of deglycobleomycin A(5).
- A new 7,8-euphadien-type triterpenoid from Brackenridgea nitida and Bleasdalea bleasdalei that inhibits DNA polymerase beta.
- Synthesis and DNA cleavage activity of a novel bleomycin A(5) glycoconjugate.
- Effect of 2'-5' phosphodiesters on DNA transesterification by vaccinia topoisomerase.
- Metallobleomycin-mediated cleavage of DNA not involving a threading-intercalation mechanism.
- Analogues of bleomycin: synthesis of conformationally rigid methylvalerates.
- Isolation and biochemical characterization of a new topoisomerase I inhibitor from Ocotea leucoxylon.
- Harbinatic acid, a novel and potent DNA polymerase beta inhibitor from Hardwickia binata.
- DNA polymerase beta inhibitors from Sandoricum koetjape.
- Use of COMPARE analysis to discover new natural product drugs: isolation of camptothecin and 9-methoxycamptothecin from a new source.
- Naturally occurring alkylresorcinols that mediate DNA damage and inhibit its repair.
- Use of COMPARE analysis to discover functional analogues of bleomycin.
- Fe.bleomycin as a probe of RNA conformation.
- Kinetics of DNA cleavage by Fe(II).bleomycins.
- DNA duplexes containing 3'-deoxynucleotides as substrates for DNA topoisomerase I cleavage and ligation.
- Probing the S1/S1' substrate binding pocket geometry of HIV-1 protease with modified aspartic acid analogues.
- Differential effects of camptothecin derivatives on topoisomerase I-mediated DNA structure modification.
- DNA polymerase beta inhibitors from Tetracera boiviniana.
Schools
University of Miami School of Medicine
Jackson Mem HospJackson Health
Doctors Specialties
- Diagnostic Radiology
- Nuclear Medicine
- Radiology
Accepted Insurances
Education
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Jackson Memorial Hospital - Jackson Health System -
University of Miami Miller School of Medicine
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