Professor, Internal Medicine, University of Arkansas COM
Internal Medicine
Dr. Stavros C. Manolagas, MD
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Doctor Stavros C. Manolagas, MD works in the field of Internal Medicine. Dr. Stavros C. Manolagas is a published physician as well. He has 102 publications published. The latest was: Interleukin-6-type cytokines stimulate mesenchymal progenitor differentiation toward the osteoblastic lineage. He accepts Medicare payments and is registered with Medicare.gov.
Publications
- Effects of sex steroids on bones and muscles: Similarities, parallels, and putative interactions in health and Disease.
- Sirtuin1 suppresses osteoclastogenesis by deacetylating FoxOs.
- Suppression of autophagy in osteocytes does not modify the adverse effects of glucocorticoids on cortical bone.
- The effects of androgens on murine cortical bone do not require AR or ERα signaling in osteoblasts and osteoclasts.
- Sirtuin1 (Sirt1) Promotes Cortical Bone Formation by Preventing beta (β)-Catenin Sequestration by FoxO Transcription Factors in Osteoblast Progenitors.
- Reproducibility of Results in Pre-Clinical Studies: A Perspective from the Bone Field.
- Osteocyte-derived RANKL is a critical mediator of the increased bone resorption caused by dietary Calcium deficiency.
- Wnt signaling and Osteoporosis.
- Dysapoptosis of osteoblasts and osteocytes increases cancellous bone formation but exaggerates cortical porosity with age.
- Skeletal aging: from bench to bed side.
- The role of estrogen and androgen receptors in bone health and Disease.
- Steap4 Plays a Critical Role in Osteoclastogenesis in vitro by Regulating Cellular Iron/ROS Levels and CREB Activation.
- Suppression of Autophagy in Osteocytes Mimics Skeletal Aging.
- Non-Nuclear-Initiated Actions of the Estrogen Receptor Protect Cortical Bone Mass.
- Estrogen receptor-? signaling in osteoblast progenitors stimulates cortical bone accrual.
- Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids.
- Proteasomal degradation of Runx2 shortens paraThyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administrati...
- A patient with pseudohypoparaThyroidism.
- Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength.
- The skeletal effects of glucocorticoid excess override those of orchidectomy in mice.
- In vivo visualization of aging-associated gene transcription: evidence for free radical theory of aging.
- Kinase-mediated transcription, activators of nongenotropic estrogen-like signaling (ANGELS), and Osteoporosis: a different perspective on the HRT dilemma.
- Transient versus sustained phosphorylation and nuclear accumulation of ERKs underlie anti-versus pro-apoptotic effects of estrogens.
- Bisphosphonates and estrogens inhibit osteocyte apoptosis via distinct molecular mechanisms downstream of extracellular signal-regulated kinase activation.
- Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation.
- Nongenotropic, anti-apoptotic signaling of 1alpha,25(OH)2-Vitamin D3 and analogs through the ligand binding domain of the Vitamin D receptor in osteoblasts and osteocy...
- Response to Windahl et al.
- Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor.
- A novel locus on the X chromosome regulates post-maturity bone density changes in mice.
- Quantifying osteoblast and osteocyte apoptosis: challenges and rewards.
- Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival. Evidence for inside-out signaling leading to anoikis.
- A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction.
- Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose Metabolism.
- Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription.
- Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids.
- Extracellular matrix made by bone marrow cells facilitates expansion of marrow-derived mesenchymal progenitor cells and prevents their differentiation into osteoblasts.
- Targeted deletion of a distant transcriptional enhancer of the receptor activator of nuclear factor-kappaB ligand gene reduces bone remodeling and increases bone mass.
- De-fense! De-fense! De-fense: scavenging H2O2 while making cholesterol.
- Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo.
- Control of bone mass and remodeling by PTH receptor signaling in osteocytes.
- Intermittent PTH stimulates periosteal bone formation by actions on post-mitotic preosteoblasts.
- Giant osteoclast formation and long-term oral bisphosphonate therapy.
- Commitment to the osteoblast lineage is not required for RANKL gene expression.
- Increased Lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling i...
- Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha.
- Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice.
- From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of Osteoporosis.
- The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone.
- FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice.
- Hormones and genes of importance in bone physiology and their influence on bone mineralization and growth in Turner syndrome.
- What old means to bone.
- Intermittent paraThyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength ...
- Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and -independent mechanisms.
- Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta/p66shc signaling cascade: counter regulation by estrogens or androgens.
- Osteoprotegerin prevents glucocorticoid-induced osteocyte apoptosis in mice.
- Matrix-embedded cells control osteoclast formation.
- Glucocorticoids and tumor necrosis factor ? increase oxidative stress and suppress Wnt protein signaling in osteoblasts.
- LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1.
- The RANKL Distal Control Region Is Required for the Increase in RANKL Expression, But Not the Bone Loss, Associated with HyperparaThyroidism or Lactation in Adult Mice.
- Transduction of cell survival signals by connexin-43 hemichannels.
- Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids.
- Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation.
- ParaThyroid hormone stimulates receptor activator of NFkappa B ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-...
- IL-6 is not required for paraThyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in mice.
- Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss.
- Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs.
- ParaThyroid hormone controls receptor activator of NF-kappaB ligand gene expression via a distant transcriptional enhancer.
- Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades ...
- Interspecies synteny mapping identifies a quantitative trait locus for bone mineral density on human chromosome Xp22.
- Characterization of a human osteoblastic osteosarcoma cell line (SAOS-2) with high bone alkaline phosphatase activity.
- The effects of gamma-interferon on human peripheral blood monocyte/macrophage-mediated bone particle degradation.
- Demonstration of insulin receptors and modulation of alkaline phosphatase activity by insulin in rat osteoblastic cells.
- Effect of daily oral vitamin D and calcium therapy, hypophosphatemia, and endogenous 1-25 dihydroxycholecalciferol on paraThyroid hormone and phosphate wasting in rena...
- Vitamin D receptor quantitation in human blood mononuclear cells in health and Disease.
- Demonstration of estrogen and Vitamin D receptors in bone marrow-derived stromal cells: up-regulation of the estrogen receptor by 1,25-dihydroxyVitamin-D3.
- Increased interleukin-6 production by murine bone marrow and bone cells after estrogen withdrawal.
- Stimulation of interleukin-6 production by either calcitonin gene-related peptide or paraThyroid hormone in two phenotypically distinct bone marrow-derived murine stro...
- Cytokine production and surface antigen expression by peripheral blood mononuclear cells in postmenopausal Osteoporosis.
- FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation.
- Estrogen, cytokines, and the control of osteoclast formation and bone resorption in vitro and in vivo.
- Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic...
- Role of cytokines in bone resorption.
- Sex steroids, cytokines and the bone marrow: new concepts on the pathogenesis of Osteoporosis.
- Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence.
- Pathogenesis and management of bone lesions in multiple myeloma.
- Quantification of Vitamin D receptor mRNA by competitive polymerase chain reaction in PBMC: lack of correspondence with common allelic variants.
- Isolation and characterization of the human gp130 promoter. Regulation by STATS.
- Osteopontin expression by osteoclast and osteoblast progenitors in the murine bone marrow: demonstration of its requirement for osteoclastogenesis and its increase aft...
- Activation of the Janus kinase/STAT (signal transducer and activator of transcription) signal transduction pathway by interleukin-6-Type cytokines promotes osteoblast ...
- The effects of androgen Deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage.
- Regulation of the gp80 and gp130 subunits of the IL-6 receptor by sex steroids in the murine bone marrow.
- Increased adipogenesis and myelopoiesis in the bone marrow of SAMP6, a murine model of defective osteoblastogenesis and low turnover Osteopenia.
- The pathophysiologic roles of interleukin-6 in human Disease.
- Loss of estrogen upregulates osteoblastogenesis in the murine bone marrow. Evidence for autonomy from factors released during bone resorption.
- Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines.
- The role of IL-6 Type cytokines and their receptors in bone.
- Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone.
- Transcriptional activation of the p21(WAF1,CIP1,SDI1) gene by interleukin-6 Type cytokines. A prerequisite for their pro-differentiating and anti-apoptotic effects on ...
- Cellular and molecular mechanisms of Osteoporosis.
- Interleukin-6-Type cytokines stimulate mesenchymal progenitor differentiation toward the osteoblastic lineage.
- Skeletal Inflammation and Attenuation of Wnt Signaling, Wnt Ligand Expression and Bone Formation in Atherosclerotic ApoE Null Mice.
Conditions Treated
- Abnormal Thyroid
- Adrenogenital Disorders
- Calcium Metabolism Disorders
- Diabetes Type 2
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Doctors Specialties
- Internal Medicine
Accepted Insurances
Drug Facts
| NPI NUMBER | 1760572242 | |
| NPPES Provider LastName | MANOLAGAS | |
| NPPES Provider FirstName | STAVROS | |
| NPPES Provider ZIPCode | 722057101 | |
| NPPES Provider State | AR | |
| Specialty Description | Endocrinology | |
| Total Claim Count | 27.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1760572242 |
| Last Name Of The Provider | MANOLAGAS |
| First Name Of The Provider | STAVROS |
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