Professor, Pediatrics, Perelman School of Medicine
Pediatric Hematology & Oncology
Dr. Stephan A. Grupp, MD
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Stephan A. Grupp works in the field of Pediatric Hematology & Oncology. He studied medicine at University of Cincinnati College of Medicine. He has 4 awards "America's Top Doctors", "America's Top Doctors for Cancer", "Philadelphia Magazine" and "Super Doctor". Doctor Stephan A. Grupp, MD is a published doctor and has 60 publications published. The lastest was: 'Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy.'
Publications
- Sirolimus is effective in relapsed/refractory autoimmune cytopenias: results of a prospective multi-institutional trial.
- Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy.
- Will Post-Transplantation Cell Therapies for Pediatric Patients Become Standard of Care?
- Efficacy of JAK/STAT pathway inhibition in murine xenoGraft models of early T-cell precursor (ETP) acute lymphoblastic leukemia.
- TNF-receptor inhibitor therapy for the treatment of children with idiopathic pneumonia syndrome. A joint Pediatric Blood and Marrow Transplant Consortium and Children'...
- Chimeric antigen receptor T-Cell therapy for ALL.
- Nature of Tumor Control by Permanently and Transiently Modified GD2 Chimeric Antigen Receptor T Cells in XenoGraft Models of Neuroblastoma.
- Tacrolimus/sirolimus versus tacrolimus/methotrexate as GVHD prophylaxis after matched, related donor allogeneic hematopoietic Cell transplantation.
- Engineered T Cells for cancer therapy.
- How I treat: current concepts in the diagnosis and management of cytokine release syndrome.
- Efficacy against human acute myeloid leukemia and myeloablation of normal hematopoiesis in a mouse model using chimeric antigen receptor-modified T Cells.
- Antibody modified T cells: CARs take the front seat for hematologic Malignancies.
- The addition of sirolimus to tacrolimus/methotrexate GVHD prophylaxis in children with ALL: a phase III COG/PBMTC trial.
- Toxicity management for patients receiving novel T-Cell engaging therapies.
- Relation of clinical culture method to T-cell memory status and efficacy in xenoGraft models of adoptive immunotherapy.
- Chimeric Antigen Receptor Therapy for Cancer.
- Regimen-Specific Effects of RNA-Modified Chimeric Antigen Receptor T Cells in Mice with Advanced Leukemia.
- Purged versus non-purged peripheral blood stem-Cell transplantation for high-risk neuroblastoma (COG A3973): a randomised phase 3 trial.
- Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine directed therapy.
- Chimeric antigen receptor-modified T Cells for acute lymphoid leukemia.
- Allogeneic hematopoietic Cell transplantation for neuroblastoma: the CIBMTR experience.
- A pilot study of tandem high-dose chemotherapy with stem Cell rescue as consolidation for high-risk neuroblastoma: Children's Oncology Group study ANBL00P1.
- Sirolimus Pharmacokinetics in Early Postmyeloablative Pediatric Blood and Marrow Transplantation.
- Targeting the PI3K/AKT/mTOR Signaling Axis in Children with Hematologic Malignancies.
- Neuroblastoma: issues in transplantation.
- Non-invasive bioluminescent imaging of primary patient acute lymphoblastic leukemia: a strategy for pre-clinical modeling.
- Treatment of advanced leukemia in mice with mRNA engineered T Cells.
- T Cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia.
- Phase I Study of Temsirolimus in Pediatric Patients With Recurrent/Refractory Solid Tumors.
- Randomized Trial of Hydroxychloroquine for Newly Diagnosed Chronic Graft-versus-Host Disease in Children: A Children's Oncology Group Study.
- Early and Late Extensive Chronic Graft-versus-Host Disease in Children Is Characterized by Different Th1/Th2 Cytokine Profiles: Findings of the Children's Oncology Gro...
- Statins are active in acute lymphoblastic leukaemia (ALL): a therapy that may treat ALL and prevent avascular necrosis.
- Cutting edge: Lymphoproliferation caused by Fas deficiency is dependent on the transcription factor eomesodermin.
- Identifying autoimmune lymphoproliferative syndrome in children with Evans syndrome: a multi-institutional study.
- Natural killer Cell consolidation for acute myelogenous leukemia: a Cell therapy ready for prime time?
- Autologous and allogeneic Cellular therapies for high-risk pediatric solid tumors.
- Interferon-gamma-dependent infiltration of human T Cells into neuroblastoma tumors in vivo.
- Long-term protection from syngeneic acute lymphoblastic leukemia by CpG ODN-mediated stimulation of innate and adaptive immune responses.
- Reduced-intensity allogeneic transplantation in pediatric patients ineligible for myeloablative therapy: results of the Pediatric Blood and Marrow Transplant Consortiu...
- Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T Cells and increased antileukemic efficacy in vivo.
- Late effects in survivors of tandem peripheral blood stem Cell transplant for high-risk neuroblastoma.
- mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia.
- Targeting Notch signaling in autoimmune and lymphoproliferative Disease.
- Novel molecular and cellular therapeutic targets in acute lymphoblastic leukemia and lymphoproliferative Disease.
- Immunotherapy for pediatric cancer.
- A prospective study of G-CSF primed bone marrow as a stem-Cell source for allogeneic bone marrow transplantation in children: a Pediatric Blood and Marrow Transplant C...
- Thymic stromal-derived lymphopoietin induces proliferation of pre-B leukemia and antagonizes mTOR inhibitors, suggesting a role for interleukin-7Ralpha signaling.
- In vivo control of acute lymphoblastic leukemia by immunostimulatory CpG oligonucleotides.
- Immunosurveillance and survivin-specific T-Cell immunity in children with high-risk neuroblastoma.
- Rapamycin improves lymphoproliferative Disease in murine autoimmune lymphoproliferative syndrome (ALPS).
- High-risk neuroblastoma treated with tandem autologous peripheral-blood stem Cell-supported transplantation: long-term survival update.
- Use of G-CSF in matched sibling donor pediatric allogeneic transplantation: a consensus statement from the Children's Oncology Group (COG) Transplant Discipline Commit...
- The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL.
- Unmasking Evans syndrome: T-Cell phenotype and apoptotic response reveal autoimmune lymphoproliferative syndrome (ALPS).
- RNA-transfected CD40-activated B Cells induce functional T-Cell responses against viral and tumor antigen targets: implications for pediatric immunotherapy.
- Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling.
- Role of the BCR complex in B Cell development, activation, and leukemic transformation.
- Cytoplasmic micro heavy chain confers sensitivity to dexamethasone-induced apoptosis in early B-lineage acute lymphoblastic leukemia.
- Managing cytokine release syndrome associated with novel T Cell-engaging therapies.
Schools
University of Cincinnati Main Campus
Children39s Hospital Boston
Dana Farber Cancer Institute
Procedures Preformed
- Bone Marrow Transplant
- HPC Transplantation (Stem Cell Transplant)
Conditions Treated
- Anemia
- Graft vs Host Disease
- Myeloproliferative Disorders
- Neutropenia
- View All
Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Local Value Network EPO
- Local Value Network HMO
- Local Value Network HMO+
- Local Value Network POS+
- Local Value Network PPO
- Personal Choice PPO
- Regional Pref Network EPO
- Regional Pref Network HMO
- Regional Pref Network HMO+
- Regional Pref Network POS+
- Regional Pref Network PPO
- Blue Card PPO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Commercial Insurance Company
- GHI PPO
- Geisinger Health Plan
- Community Blue PPO
- Advance EPO
- Direct Access
- Horizon Blue Cross Blue Shield HMO
- Horizon Blue Cross Blue Shield POS
- Horizon Blue Cross Blue Shield PPO
- Choice Care PPO
- Keystone Health Plan East HMO
- Medicaid
- Medicare MCR
- MultiPlan PPO
- Freedom Plan
- QualCare HMO
- QualCare PPO
- Tricare
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- Oxford Liberty
- United Healthcare
Awards
- America's Top Doctors
- America's Top Doctors for Cancer
- Philadelphia Magazine
- Super Doctor
Education
-
Boston Children's Hospital -
University of Cincinnati College of Medicine
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