Professor, Internal Medicine, Wayne State University School of Medicine
Infectious Disease
Dr. Stephen A. Lerner, MD
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Stephen Lerner works in the field of Infectious Disease. He studied medicine at Harvard Medical School. Harvard Medical School is a top medical university. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. He received 1 awards: "Whos Who in Medicine and Healthcare". Stephen A. Lerner, MD is a published doctor and has 48 publications published. The lastest was: 'Selection and characterization of beta-lactam-beta-lactamase inactivator-resistant mutants following PCR mutagenesis of the TEM-1 beta-lactamase gene.' Stephen Lerner accepts Medicare payments and is listed with Medicare.gov.
Publications
- Tackling antibiotic resistance.
- Improvements in antimicrobial prescribing for treatment of upper respiratory tract infections through provider education.
- Multiplex PCR for detection of aminoglycoside resistance genes in enterococci.
- Mutations in the aph(2")-Ic gene are responsible for increased levels of aminoglycoside resistance.
- Mutational replacement of Leu-293 in the class C Enterobacter cloacae P99 beta-lactamase confers increased MIC of cefepime.
- Effect of clavulanic acid on the in vitro synergism between carbenicillin and gentamicin against Serratia marcescens.
- Effects of radiopharmaceuticals on radioenzymatic assays of aminoglycoside antibiotics: interference by gallium-67 and its elimination.
- In vitro activity of gentamicin, amikacin and netilmicin alone and in combination with carbenicillin against Serratia marcescens.
- Simplified radioenzymatic assay for chloramphenicol.
- Lack of accumulation of exogenous adenylyl dihydrostreptomycin by whole cells or spheroplasts of Escherichia coli.
- Decreased susceptibility to 4'-deoxy-6'-N-methylamikacin (BB-K311) conferred by a mutant plasmid in Escherichia coli.
- Isolation, characterization, and cloning of a plasmid-borne gene encoding a phosphotransferase that confers high-level amikacin resistance in enteric bacilli.
- Characteristics of pathogenic Neisseria spp. isolated from homosexual men.
- Susceptibility of Neisseria meningitidis and Neisseria gonorrhoeae isolates to N-formimidoyl thienamycin.
- Trimethoprim/sulfamethoxazole-induced tremor in a patient with AIDS.
- Isolation and characterization of a species-specific DNA probe for Candida albicans.
- The clinical use of fluoroquinolones for the treatment of mycobacterial diseases.
- Randomized, double-blind comparative study of intravenous ciprofloxacin versus ceftazidime in the treatment of serious infections.
- Rare presentation of Streptococcus pneumoniae pneumonia with bacteremia and multiple subcutaneous abscesses.
- High-level amikacin resistance in Escherichia coli due to phosphorylation and impaired aminoglycoside uptake.
- Emergence of resistance to imipenem during therapy for Pseudomonas aeruginosa infections.
- High-level amikacin resistance in Pseudomonas aeruginosa associated with a 3''-phosphotransferase with high affinity for amikacin.
- Emergence of teicoplanin resistance during therapy of Staphylococcus aureus endocarditis.
- Clinical impact of antibiotic resistance.
- A comparative study of the broth micro- and macro-dilution techniques for the determination of the in vitro susceptibility of Aspergillus fumigatus.
- Correlation of aminoglycoside resistance with the KmS and Vmax/Km ratios of enzymatic modification of aminoglycosides by 2''-O-nucleotidyltransferase.
- Effect of highly potent antipseudomonal beta-lactam agents alone and in combination with aminoglycosides against Pseudomonas aeruginosa.
- Teicoplanin pharmacokinetics in intravenous drug abusers being treated for bacterial endocarditis.
- Emergence of resistance to beta-lactam antibiotics in Pseudomonas aeruginosa during treatment with new beta-lactams.
- Amikacin resistance associated with a plasmid-borne aminoglycoside phosphotransferase in Escherichia coli.
- Monitoring beta-lactamase activity in vivo by 13C nuclear magnetic resonance spectroscopy.
- Isolation and characterization of a species-specific DNA probe for the detection of Candida krusei.
- Conjoint molecules of cephalosporins and aminoglycosides.
- Prospective evaluation of the effect of an aminoglycoside dosing regimen on rates of observed nephrotoxicity and ototoxicity.
- Elucidation of the role of arginine-244 in the turnover processes of class A beta-lactamases.
- Purification and characterization of aminoglycoside 3'-phosphotransferase type IIa and kinetic comparison with a new mutant enzyme.
- Purification, crystallization and preliminary X-ray analysis of Enterococcus faecium aminoglycoside-2''''-phosphotransferase-Ib [APH(2'''')-Ib].
- Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis.
- Characterization of fluoroquinolone-resistant mutant strains of Mycobacterium tuberculosis selected in the laboratory and isolated from patients.
- Critical hydrogen bonding by serine 235 for cephalosporinase activity of TEM-1 beta-lactamase.
- Reversal of clavulanate resistance conferred by a Ser-244 mutant of TEM-1 beta-lactamase as a result of a second mutation (Arg to Ser at position 164) that enhances ac...
- Aminoglycoside resistance genes aph(2")-Ib and aac(6')-Im detected together in strains of both Escherichia coli and Enterococcus faecium.
- A novel gentamicin resistance gene in Enterococcus.
- Effects of Asp-179 mutations in TEMpUC19 beta-lactamase on susceptibility to beta-lactams.
- Selection and characterization of beta-lactam-beta-lactamase inactivator-resistant mutants following PCR mutagenesis of the TEM-1 beta-lactamase gene.
- Effects on substrate profile by mutational substitutions at positions 164 and 179 of the class A TEM(pUC19) beta-lactamase from Escherichia coli.
- Accuracies of beta-lactam susceptibility test results for Pseudomonas aeruginosa with four automated systems (BD Phoenix, MicroScan WalkAway, Vitek, and Vitek 2).
Schools
Harvard Medical School
Brigham and Women39s Hospital
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
Awards
- Whos Who in Medicine and Healthcare
Education
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Stanford University -
Brigham and Women's Hospital -
Harvard Medical School
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1881634343 |
| Last Name Of The Provider | LERNER |
| First Name Of The Provider | STEPHEN |
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