Associate Professor, Internal Medicine, Washington University School of Medicine

Endocrinology

Stephen Giddings works in the field of Endocrinology. He researched medicine at University of Rochester School of Medicine and Dentistry. Stephen Giddings is a published doctor as well. He has 34 publications published. The latest was: CYP4A1 gene transfection studies and the peroxisome proliferator-activated receptor: development of a high-throughput assay to detect peroxisome proliferators.

Publications

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• Insulin gene structure and function: a review of studies using recombinant DNA methodology.
• Insulin biosynthesis and diabetes mellitus.
• Biosynthesis of rat insulins I and II: evidence for differential expression of the two genes.
• An early cordycepin-sensitive event in the action of glucocorticoid hormones on rat thymus cells in vitro: evidence that synthesis of new mRNA initiates the earliest m...
• A variant insulin promoter in non-insulin-dependent diabetes mellitus.
• Effects of glucose on proinsulin messenger RNA in rats in vivo.
• Insulin receptor gene expression during development: developmental regulation of insulin receptor mRNA abundance in embryonic rat liver and yolk sac, developmental reg...
• Alternative splicing for the alpha1 subunit of soluble guanylate cyclase.
• CYP4A1 gene transfection studies and the peroxisome proliferator-activated receptor: development of a high-throughput assay to detect peroxisome proliferators.
• Shortening of poly (A) tail of glucose transporter--one mRNA in experimental diabetes mellitus.
• Hypoglycemia but not hyperglycemia induces rapid changes in pancreatic beta-cell gene transcription.
• Insulin II gene expression in rat central nervous system.
• Insulin gene expression and insulin synthesis in mammalian neuronal cells.
• Time course for effects of hypoglycemia on insulin gene transcription in vivo.
• Allele specific inactivation of insulin 1 and 2, in the mouse yolk sac, indicates imprinting.
• Age-related changes in pancreatic islet cell gene expression.
• Analysis of insulin gene expression in human pancreas.
• Insulin gene expression in the developing rat pancreas.
• Diagnosis and management of hypoglycemic disorders in adults.
• An in vivo analysis of pancreatic protein and insulin biosynthesis in a rat model for non-insulin-dependent diabetes.
• The effects of fasting and feeding on preproinsulin messenger RNA in rats.
• Differences in the subcellular localization of the stimulatory effects of glucose and pyruvate on protein synthesis in rat thymus cells in vitro.
• An in vitro effect of physiological levels of cortisol and related steroids on the structural integrity of the nucleus in rat thymic lymphocytes as measured by resista...
• Glucose regulated insulin biosynthesis in isolated rat pancreatic islets is accompanied by changes in proinsulin mRNA.
• Impaired insulin biosynthetic capacity in a rat model for non-insulin-dependent diabetes. Studies with dexamethasone.
• The two nonallelic rat insulin mRNAs and pre-mRNAs are regulated coordinately in vivo.
• Rat insulin II gene expression by extraplacental membranes. A non-pancreatic source for fetal insulin.
• Proinsulin I and II gene expression in inbred mouse strains.
• Evaluation of rat insulin messenger RNA in pancreatic and extrapancreatic tissues.
• Selective expression of the insulin I gene in rat insulinoma-derived cell lines.
• Selective expression and developmental regulation of the ancestral rat insulin II gene in fetal liver.
• Rapid alteration of pancreatic proinsulin and preproinsulin messenger ribonucleic acid in rats treated with cyproheptadine.
• Differential regulation of rat insulin I and II messenger RNA synthesis: effects of fasting and cyproheptadine.

Schools

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• Univ Of Rochester Sch Of Med amp Dentistry

Doctors Specialties

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• Internal Medicine
• Endocrinology

Accepted Insurances

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Education

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• Washington University - Barnes-Jewish Hospital
• University of Rochester School of Medicine and Dentistry

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