Professor, Internal Medicine, Virginia Commonwealth University, Medical College of Virginia School of Medicine
Oncology
Dr. Steven R. Grossman, MD
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Steven Grossman works in the field of Oncology. He researched medicine at University of Chicago Pritzker School of Medicine. University of Chicago Pritzker School of Medicine is ranked 10 in research and 19 in primary care medicine Doctor Steven R. Grossman, MD is a published MD. He has 30 papers published. The most current publication "Structure-Guided Design of a High Affinity Inhibitor to Human CtBP."
Publications
- Structure-Guided Design of a High Affinity Inhibitor to Human CtBP.
- Inhibition of C-terminal binding protein attenuates transcription factor 4 signaling to selectively target colon Cancer stem cells.
- Pancreatic Cancer-specific cell death induced in vivo by cytoplasmic-delivered polyinosine-polycytidylic acid.
- NIAM's tangled web of growth control.
- Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design.
- The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing.
- p53 Ubiquitination and Proteasomal Degradation.
- Gain-of-Function Activity of Mutant p53 in Lung Cancer through Up-Regulation of Receptor Protein Tyrosine Kinase Axl.
- CtBP2 Promotes Human Cancer Cell Migration by Transcriptional Activation of Tiam1.
- The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3.
- It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53.
- The ARF tumor suppressor inhibits tumor cell colonization independent of p53 in a novel mouse model of Pancreatic ductal adenocarcinoma metastasis.
- Ubiquitin becomes ubiquitous in Cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets.
- Therapeutic targeting of C-terminal binding protein in human Cancer.
- Mdm2 facilitates the association of p53 with the proteasome.
- CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53.
- Occam's dull razor: MDM2 and P/CAF keep Chk2 in check the hard way.
- p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein.
- Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: a model of age-related tumorigenesis in mice.
- The alternative reading frame tumor suppressor antagonizes hypoxia-induced Cancer cell migration via interaction with the COOH-terminal binding protein corepressor.
- p66 Shc tumor levels show a strong prognostic correlation with disease outcome in stage IIA colon Cancer.
- Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism.
- Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis.
- ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation.
- Yin Yang 1 is a negative regulator of p53.
- Physical and functional interactions between PML and MDM2.
- Polyubiquitination of p53 by a ubiquitin ligase activity of p300.
- A Phase II study of gemcitabine and docetaxel in patients with metastatic Pancreatic carcinoma.
- Mechanisms of Mutant p53 Stabilization in Cancer.
Schools
Pritzker School Of Med University Of Chicago
Brigham and Women39s Hospital
Dana Farber Cancer Institute
Conditions Treated
- Anal and Rectal Cancer
- Anemia
- Bladder Cancer
- Coagulation Disorders (incl. Hemophilia)
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Doctors Specialties
- Medical Oncology
- Oncology
Accepted Insurances
Education
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Brigham and Women's Hospital -
University of Chicago Pritzker School of Medicine
Drug Facts
| NPI NUMBER | 1790768638 | |
| NPPES Provider LastName | GROSSMAN | |
| NPPES Provider FirstName | STEVEN | |
| NPPES Provider ZIPCode | 232985051 | |
| NPPES Provider State | VA | |
| Specialty Description | Hematology/Oncology | |
| Total Claim Count | 46.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1790768638 |
| Last Name Of The Provider | GROSSMAN |
| First Name Of The Provider | STEVEN |
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