Professor of Neurosurgery and Chief, Neurosurgical Oncology
Neurosurgery
Dr. Steven S. Brem, MD
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Doctor Steven S. Brem, MD works in the field of Neurosurgery. He graduated from Harvard Medical School. Harvard Medical School is a one of the best medicals schools. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. He has 5 awards "America's Top Doctors", "America's Top Doctors for Cancer", "CMS Meaningful Use Stage 1 Certification", "Fellow (FACS)" and "Fellow (FAANS)". Steven Brem is also published. He has 69 publications published. The lastest publication: "The role of vascular proliferation in the growth of brain tumors.'
Publications
- Senescence-Associated-Gene signature identifies genes linked to age, prognosis, and progression of human Gliomas.
- A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma m...
- Preservation of neurocognitive function and local control of 1 to 3 Brain metastases treated with surgery and carmustine wafers.
- Targeted delivery of antibody-based therapeutic and imaging agents to CNS tumors: crossing the blood-Brain barrier divide.
- Intracranial control after Cyberknife radiosurgery to the resection bed for large Brain metastases.
- Tumor angiogenesis: a quantitative method for histologic grading.
- Experimental retinal neovascularization induced by intravitreal tumors.
- Angiogenesis as a marker of preneoplastic lesions of the human breast.
- A diaminoantraquinone inhibitor of angiogenesis.
- Neovascularization and the atherosclerotic plaque.
- Utilization of the HTSCA and CFU-C assay to identify two new 2-chloroethylnitrosourea congeners of amino acid amides with increased in vitro activity against human gli...
- Angiogenesis: a marker for neoplastic transformation of mammary papillary hyperplasia.
- A rapid and modifiable technique for regional exposure in Cerebral surgery. Technical note.
- The prevention of oxyhemoglobin-induced endothelial and smooth muscle cytoskeletal Injury by deferoxamine.
- Terson's syndrome: a reversible cause of blindness following subarachnoid Hemorrhage.
- Angiogenic activity of the atherosclerotic carotid Artery plaque.
- Myiatic scalp and skull infection with diptera Sarcophaga: case report.
- Tumor growth regulation by modulation of basic fibroblast growth factor.
- Angiogenesis antagonists: current clinical trials.
- Statin immunolocalization in human Brain tumors. Detection of noncycling cells using a novel marker of cell quiescence.
- The cycling pool of cells within human Brain tumors: in situ cytokinetics using the monoclonal antibody Ki-67.
- Elevated levels of urokinase-type plasminogen activator and plasminogen activator inhibitor type-1 in malignant human Brain tumors.
- Neovascularization and tumor growth in the rabbit Brain. A model for experimental studies of angiogenesis and the blood-Brain barrier.
- Prolonged tumor dormancy by prevention of neovascularization in the vitreous.
- The role of vascular proliferation in the growth of Brain tumors.
- Angiogenesis and blood-Brain barrier breakdown modulate CT contrast enhancement: an experimental study in a rabbit Brain-tumor model.
- Suramin inhibits glioma cell proliferation in vitro and in the Brain.
- Expression of plasminogen activator inhibitor type 1 by human prostate carcinoma cells inhibits primary tumor growth, tumor-associated angiogenesis, and metastasis to ...
- Inhibition of angiogenesis and tumor growth in the Brain. Suppression of endothelial cell turnover by penicillamine and the depletion of copper, an angiogenic cofactor.
- Can calcium antagonists affect the hemostatic mechanism and promote rebleeding? An experimental study.
- Rapid in situ cellular kinetics of intraCerebral tumor angiogenesis using a monoclonal antibody to bromodeoxyuridine.
- The potential role of basic fibroblast growth factor in the transformation of cultured primary human fetal astrocytes and the proliferation of human glioma (U-87) cells.
- Cells transfected with the basic fibroblast growth factor gene fused to a signal sequence are invasive in vitro and in situ in the Brain.
- Survival rates in patients with primary malignant Brain tumors stratified by patient age and tumor histological type: an analysis based on Surveillance, Epidemiology, ...
- Anticopper treatment inhibits pseudopodial protrusion and the invasive spread of 9L gliosarcoma cells in the rat Brain.
- Suramin, an antiCancer and angiosuppressive agent, inhibits endothelial cell binding of basic fibroblast growth factor, migration, proliferation, and induction of urok...
- Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent Gliomas. The Polymer-brai...
- Malignant Brain tumors in the elderly.
- MRI measurement of Brain tumor response: comparison of visual metric and automatic segmentation.
- Phase I trial of vorinostat combined with bevacizumab and CPT-11 in recurrent glioblastoma.
- Bevacizumab for recurrent glioblastoma multiforme: a meta-analysis.
- Cancer susceptibility variants and the risk of adult glioma in a US case-control study.
- Taming glioblastoma by targeting angiogenesis: 3 years later.
- Impaired orthotopic glioma growth and vascularization in transgenic mouse models of Alzheimer's Disease.
- Relationship of Gliomas to the ventricular walls.
- Antiangiogenesis treatment for glioblastoma multiforme: challenges and opportunities.
- Guidelines for the initial management of metastatic Brain tumors: role of surgery, radiosurgery, and radiation therapy.
- Potent anti-angiogenic motifs within the Alzheimer beta-amyloid peptide.
- Taming glioblastoma: targeting angiogenesis.
- Vascular complications after radiosurgery for Meningiomas.
- Treatment of single Brain metastasis with resection, intracavity carmustine polymer wafers, and radiation therapy is safe and provides excellent local control.
- Phase 2 trial of copper depletion and penicillamine as antiangiogenesis therapy of glioblastoma.
- New frontiers in translational research in neuro-oncology and the blood-Brain barrier: report of the tenth annual Blood-Brain Barrier Disruption Consortium Meeting.
- A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-Attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent mal...
- Inhibition of angiogenesis by Abeta peptides.
- Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor.
- In vitro drug response and molecular markers associated with drug resistance in malignant Gliomas.
- Overall and progression-free survival in metastatic melanoma: analysis of a single-institution database.
- An era of rapid advancement: diagnosis and treatment of metastatic Brain cancer.
- Neuroimaging of metastatic Brain disease.
- Local treatment of malignant Brain tumors using implantable chemotherapeutic polymers.
- An inflatable balloon catheter and liquid 125I radiation source (GliaSite Radiation Therapy System) for treatment of recurrent malignant glioma: multicenter safety and...
- Complete response of a recurrent, multicentric malignant glioma in a patient treated with phenylbutyrate.
- Microscopic paraseptal sphenoidotomy approach for pituitary tumors.
- Necrotizing neurosarcoidosis masquerading as a left optic nerve meningioma: case report.
- Central Nervous system cancers: Clinical Practice Guidelines in Oncology.
- Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein.
- Central Nervous system cancers.
Schools
Harvard Medical School
Massachusetts General Hospital
Procedures Preformed
- Cerebrospinal Fluid (CSF) Shunt - Insertion, Repair or Removal
- Craniectomy, Craniotomy, Surgery of Skull Base, Neuroendoscopy
- Dural Repair or Other Spinal Spinal Cord Repair
- Lamina Procedures (incl. Laminectomy, Laminoplasty, Laminotomy)
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Conditions Treated
- Acoustic Neuroma
- Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
- Brain Aneurysm
- Brain Cancer
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Doctors Specialties
- Neurosurgery
Accepted Insurances
Awards
- America's Top Doctors
- America's Top Doctors for Cancer
- CMS Meaningful Use Stage 1 Certification
- Fellow (FACS)
- Fellow (FAANS)
Education
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Massachusetts General Hospital -
New York Presbyterian Hospital - Cornell Campus -
Harvard Medical School
Hospital
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Hospital of the University of Pennsylvania -
Pennsylvania Hospital -
Doylestown Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1538195854 |
| Last Name Of The Provider | BREM |
| First Name Of The Provider | STEVEN |
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