David G. Nathan Professor of Pediatrics, Dana-Farber Cancer Institute
Hematology
Dr. Stuart H. Orkin, MD
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Stuart Orkin works in the field of Hematology. He went to Harvard Medical School. Harvard Medical School is a one of the best medicals schools. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. He received awards:"Elected Member" and "Investigator". Stuart Orkin is a published doctor. He published 101 publications, including: 'Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia.'
Publications
- Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia.
- Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model.
- BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis.
- SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2.
- Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence.
- Functional proteomic analysis of repressive histone methyltransferase complexes PRC2 and G9A reveals ZNF518B as a G9A regulator.
- Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions.
- Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma.
- Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production.
- A comparative encyclopedia of DNA elements in the mouse genome.
- Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution.
- Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors.
- Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation.
- The co-repressor Rcor1 is essential for murine erythropoiesis.
- Analysis of chromatin-state plasticity identifies cell-type-specific regulators of H3K27me3 patterns.
- Distinct and Combinatorial Functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in Mouse Embryonic Stem Cell Identity.
- Calpain 2 Activation of P-TEFb Drives Megakaryocyte Morphogenesis and Is Disrupted by Leukemogenic GATA1 Mutation.
- Polycomb Repressive Complex 2 Regulates Normal Hematopoietic Stem Cell Function in a Developmental-Stage-Specific Manner.
- An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level.
- Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer.
- Mapping Cellular Hierarchy by Single-Cell Analysis of the Cell Surface Repertoire.
- Delineating the mixed lineage leukemia gene expression network in hematopoietic stem cells.
- Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A.
- ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients.
- Genome-wide association studies of hematologic phenotypes: a window into human hematopoiesis.
- Sustained PU.1 Levels Balance Cell-Cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem Cells.
- The Switch from Fetal to Adult Hemoglobin.
- TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes.
- Combinatorial Assembly of Developmental Stage-Specific Enhancers Controls Gene Expression Programs during Human Erythropoiesis.
- Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number.
- MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets.
- PRC2 directly methylates GATA4 and represses its transcriptional activity.
- Polycomb repressive complex 2 regulates normal development of the mouse heart.
- Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine.
- Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing.
- MicroRNA-21 Limits In Vivo Immune Response-Mediated Activation of the IL-12/IFN-{gamma} Pathway, Th1 Polarization, and the Severity of Delayed-Type Hypersensitivity.
- Zfp281 Functions as a Transcriptional Repressor for Pluripotency of Mouse Embryonic Stem Cells.
- A functional element necessary for fetal hemoglobin silencing.
- Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1.
- Chromatin connections to pluripotency and cellular reprogramming.
- Genome Medicine: stem cells, genomics and translational research.
- Context-dependent function of "GATA switch" sites in vivo.
- Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer.
- Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells.
- Update on fetal hemoglobin gene regulation in hemoglobinopathies.
- MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13.
- Dnmt3a silences hematopoietic stem cell self-renewal.
- Modifier genes in Mendelian disorders: the example of hemoglobin disorders.
- Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation.
- Networking erythropoiesis.
- Differential roles of Sall4 isoforms in embryonic stem cell pluripotency.
- Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation.
- A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs.
- Training program in cancer and blood diseases: Pediatric Hematology/Oncology Fellowship Program, Children's Hospital Boston/Dana-Farber Cancer Institute.
- Sumoylation regulates interaction of FOG1 with C-terminal-binding protein (CTBP).
- A single cis element maintains repression of the key developmental regulator Gata2.
- Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis.
- Transcriptional silencing of fetal hemoglobin by BCL11A.
- Medicine. Sickle cell disease at 100 years.
- TIF1gamma controls erythroid cell fate by regulating transcription elongation.
- Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6.
- Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome.
- miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia.
- Systematic tracking of cell fate changes.
- Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.
- Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis.
- Translational isoforms of FOG1 regulate GATA1-interacting complexes.
- DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells.
- GATA-2 reinforces megakaryocyte development in the absence of GATA-1.
- TEL-AML1 corrupts hematopoietic stem cells to persist in the bone marrow and initiate leukemia.
- Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis.
- A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal.
- Tandem affinity purification of protein complexes in mouse embryonic stem cells using in vivo biotinylation.
- Glimpses of the epigenetic landscape.
- ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling.
- Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.
- EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.
- Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos.
- GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors.
- DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease.
- Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease.
- Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis.
- Requirement of Nanog dimerization for stem cell self-renewal and pluripotency.
- PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos.
- An extended transcriptional network for pluripotency of embryonic stem cells.
- Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage.
- The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation.
- Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells.
- Hematopoiesis: an evolving paradigm for stem cell biology.
- SnapShot: hematopoiesis.
- Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis.
- Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.
- Site-directed, virus-free, and inducible RNAi in embryonic stem cells.
- ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex.
- Stem cells down under-ISSCR 2007.
- Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1.
- Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment.
- Gata4 is necessary for normal pulmonary lobar development.
- The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor.
- Serum-Based Culture Conditions Provoke Gene Expression Variability in Mouse Embryonic Stem Cells as Revealed by Single-Cell Analysis.
Schools
Harvard Medical School
Chldns Hospital
Children39s Hospital Boston
Doctors Specialties
- Pediatrics
- Hematology
Accepted Insurances
Awards
- Elected Member
- Investigator
Education
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Boston Children's Hospital -
Harvard Medical School
Hospital
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Dana-Farber Cancer Institute
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