Professor, Internal Medicine, University of Texas Southwestern Medical Center, Southwestern Medical School
Gastroenterology
Dr. Stuart J. Spechler, MD
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Stuart Spechler practices Gastroenterology. He went to medical school at Boston University School of Medicine. Boston University School of Medicine is ranked 30/52 in Research/PrimaryCare. He over the years received 2 awards: "Fellow (AGAF)" and "Fellow (FACG)". Stuart Spechler is a published MD. He published 99 publications, including: 'Proton pump inhibitor-responsive oesophageal eosinophilia: an entity challenging current diagnostic criteria for eosinophilic oesophagitis.'
Publications
- Proton pump inhibitor-responsive oEsophageal eosinophilia: an entity challenging current diagnostic criteria for eosinophilic oesophagitis.
- Cardiac mucosa: the heart of the problem.
- Quality Indicators for the Management of Barrett's Esophagus, Dysplasia, and Esophageal Adenocarcinoma: International Consensus Recommendations from the American Gastr...
- Identification of Quality Measures for Performance of and Interpretation of Data From Esophageal Manometry.
- 2014 SSAT State-of-the-Art Conference: Advances in Diagnosis and Management of Gastroesophageal Reflux Disease.
- Eosinophilic Esophagitis: Interactions with Gastroesophageal Reflux Disease.
- In Barrett's Esophagus Patients and Barrett's Cell Lines, Ursodeoxycholic Acid Increases Antioxidant Expression and Prevents DNA Damage by Bile Acids.
- Controversies in Barrett Esophagus.
- Case-control study of factors that trigger inflammatory bowel Disease flares.
- Use of hemoclips and other measures to prevent bleeding during colonoscopy by gastroenterologists in veterans affairs hospitals.
- The Prophylactic Placement of Hemoclips to Prevent Delayed Post-polypectomy Bleeding: An Unnecessary Practice? A Case Control Study.
- Development and Characterization of a Surgical Mouse Model of Reflux Esophagitis and Barrett's Esophagus.
- Autocrine VEGF signaling promotes proliferation of neoplastic Barrett's epithelial cells through a PLC-dependent pathway.
- In oEsophageal squamous cells exposed to acidic bile salt medium, omeprazole inhibits IL-8 expression through effects on nuclear factor-κB and activator protein-1.
- Barrett esophagus and risk of esophageal Cancer: a clinical review.
- Clinical implications of histologic abnormalities in colonic biopsy specimens from patients with Ulcerative colitis in clinical remission.
- Low Rate of Post-Polypectomy Bleeding Among Patients Who Continue Thienopyridine Therapy During Colonoscopy.
- Esophageal human beta-defensin expression in eosinophilic esophagitis.
- Batteryless implantable dual-sensor capsule for Esophageal reflux monitoring.
- Omeprazole Blocks STAT6 Binding to the Eotaxin-3 Promoter in Eosinophilic Esophagitis Cells.
- An implantable, batteryless, and wireless capsule with integrated impedance and pH sensors for gastroEsophageal reflux monitoring.
- Tissue Remodeling in Eosinophilic Esophagitis.
- Buried (but not dead) Barrett's metaplasia: tales from the crypts.
- Targeting the Intrinsic Inflammatory Pathway: Honokiol Exerts Pro-Apoptotic Effects through STAT3 Inhibition in Transformed Barrett's Cells.
- The Risk of Lymph-Node Metastases in Patients With High-Grade Dysplasia or Intramucosal Carcinoma in Barrett's Esophagus: A Systematic Review.
- Sorafenib for Treatment of Hepatocellular Carcinoma: A Systematic Review.
- The Impact of Obesity on the Rise in Esophageal Adenocarcinoma Incidence: Estimates from a Disease Simulation Model.
- Buried Metaplasia After Endoscopic Ablation of Barrett's Esophagus: A Systematic Review.
- Deoxycholic Acid Causes DNA Damage while Inducing Apoptotic Resistance through NF-{kappa}B Activation in Benign Barrett's Epithelial Cells.
- Pneumatic dilation and laparoscopic Heller's myotomy equally effective for Achalasia.
- Durability of radiofrequency ablation in Barrett's esophagus with dysplasia.
- Current Strategies in the Management of Intra-abdominal Abscesses in Crohn's Disease.
- Barrett's Esophagus Without Dysplasia: Wait or Ablate?
- The Rate of Post-Polypectomy Bleeding for Patients on Uninterrupted Clopidogrel Therapy During Elective Colonoscopy Is Acceptably Low.
- Cancer-related inflammation and Barrett's carcinogenesis: interleukin-6 and STAT3 mediate apoptotic resistance in transformed Barrett's cells.
- Barrett's esophagus: Clinical issues.
- Biologic agent use varies inversely with age at diagnosis in Crohn's Disease.
- Acid-induced p16 hypermethylation contributes to development of Esophageal adenocarcinoma via activation of NADPH oxidase NOX5-S.
- Acid and bile salt-induced CDX2 expression differs in Esophageal squamous cells from patients with and without Barrett's esophagus.
- A systematic review of the risk of perforation during Esophageal dilation for patients with eosinophilic esophagitis.
- History, molecular mechanisms, and endoscopic treatment of Barrett's esophagus.
- Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro.
- Malignant transformation of non-neoplastic Barrett's epithelial cells through well-defined genetic manipulations.
- Development, calibration, and validation of a U.S. white male population-based simulation model of Esophageal adenocarcinoma.
- In benign Barrett's epithelial cells, acid exposure generates reactive oxygen species that cause DNA double-strand breaks.
- Esophagitis dissecans superficialis ("sloughing esophagitis"): a clinicopathologic study of 12 cases.
- Surgery for gastroesophageal reflux Disease: esophageal impedance to progress?
- GastroEsophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury.
- Potential anti-inflammatory effects of proton pump inhibitors: a review and discussion of the clinical implications.
- Reduction in low-density lipoprotein cholesterol levels during statin therapy is associated with a reduced incidence of advanced colon polyps.
- Might the use of acid-suppressive medications predispose to the development of eosinophilic esophagitis?
- Endoscopic therapy in Barrett's esophagus: when and how?
- For patients with Colorectal cancer, the long-term use of statins is associated with better clinical outcomes.
- Multilayered epithelium in mucosal biopsy specimens from the gastroesophageal junction region is a histologic marker of gastroesophageal reflux Disease.
- Radiofrequency ablation in Barrett's esophagus with dysplasia.
- A case of duodenal Entamoeba histolytica.
- Duration of the interval between the completion of bowel preparation and the start of colonoscopy predicts bowel-preparation quality.
- Unlike Esophageal squamous cells, Barrett's epithelial cells resist apoptosis by activating the nuclear factor-kappaB pathway.
- Differences in activity and phosphorylation of MAPK enzymes in Esophageal squamous cells of GERD patients with and without Barrett's esophagus.
- Elevated HbA1c is an independent predictor of aggressive clinical behavior in patients with Colorectal cancer: a case-control study.
- Through-the-scope, wire-guided Esophageal dilation for the treatment of food impaction.
- Acid, bile, and CDX: the ABCs of making Barrett's metaplasia.
- Biomarkers and photodynamic therapy for Barrett's esophagus: time to FISH or cut bait?
- Stem cells in Barrett's esophagus: HALOs or horns?
- Mechanisms of oxidant production in Esophageal squamous cell and Barrett's cell lines.
- Fatal hyperammonemic encephalopathy after gastric bypass surgery.
- Integrated approach to treatment of children and adults with eosinophilic esophagitis.
- In non-neoplastic Barrett's epithelial cells, acid exerts early antiproliferative effects through activation of the Chk2 pathway.
- Banding without resection (endoscopic mucosal ligation) as a novel approach for the ablation of short-segment Barrett's epithelium: results of a pilot study.
- GERD is associated with shortened telomeres in the squamous epithelium of the distal esophagus.
- Thoughts on the complex relationship between gastroesophageal reflux Disease and eosinophilic esophagitis.
- NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-kappaB in Barrett's Esophageal adenocarcinoma cells.
- GERD evaluation: time for a new paradigm?
- All trans-retinoic acid induces apoptosis via p38 and caspase pathways in metaplastic Barrett's cells.
- Surgical bypass versus endoscopic stenting for malignant gastroduodenal Obstruction: a decision analysis.
- Acid has antiproliferative effects in nonneoplastic Barrett's epithelial cells.
- Gastric and Esophageal pH in patients with Barrett's esophagus treated with three esomeprazole dosages: a randomized, double-blind, crossover trial.
- Thermal ablation of Barrett's esophagus: a heated debate.
- High-frequency probe ultrasonography has limited accuracy for detecting invasive adenocarcinoma in patients with Barrett's esophagus and high-grade dysplasia or intram...
- Gain of allelic gene expression for IGF-II occurs frequently in Barrett's esophagus.
- Laryngopharyngeal Reflux: a cause of faulty phonation or a faulted, phony diagnosis?
- Bile salt exposure increases proliferation through p38 and ERK MAPK pathways in a non-neoplastic Barrett's cell line.
- Acid increases MAPK-mediated proliferation in Barrett's Esophageal adenocarcinoma cells via intracellular acidification through a Cl-/HCO3- exchanger.
- Concepts in the prevention of adenocarcinoma of the distal esophagus and proximal stomach.
- Barrett's esophagus: a molecular perspective.
- Fundoplication and the risk of esophageal Cancer in gastroesophageal reflux disease: a Veterans Affairs cohort study.
- Dysplasia in Barrett's esophagus: limitations of current management strategies.
- Differences in ERK activation in squamous mucosa in patients who have gastroesophageal reflux Disease with and without Barrett's esophagus.
- Information assimilation and distribution challenges and goals for real and virtual journals.
- Should patients with GERD be screened once at least for Barrett's epithelium? A balancing view: To screen or not to screen: scoping out the issues.
- Acid increases proliferation via ERK and p38 MAPK-mediated increases in cyclooxygenase-2 in Barrett's adenocarcinoma cells.
- Irreversible ototoxicity associated with difluoromethylornithine.
- The management of patients who have "failed" antiReflux surgery.
- Intestinal metaplasia at the gastroesophageal junction.
- Clinical manifestations and Esophageal complications of GERD.
- Nighttime heartburn is an under-appreciated clinical problem that impacts sleep and daytime function: the results of a Gallup survey conducted on behalf of the America...
- Barrett's esophagus: chemoprevention.
- The natural history of dysplasia and Cancer in esophagitis and Barrett esophagus.
Schools
Boston University School Of Medicine
Boston Va Med Center
Procedures Preformed
- Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
Conditions Treated
- Anemia
- Colorectal Cancer
- Crohn's Disease (Regional Enteritis)
- Diaphragmatic and-or Hiatal Hernia
- View All
Doctors Specialties
- Gastroenterology
Accepted Insurances
Awards
- Fellow (AGAF)
- Fellow (FACG)
Education
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Boston University School of Medicine
Hospital
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Veterans Affairs North Texas Health Care System -
University of Texas Southwestern Medical Center
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