Professor of Medicine, Professor of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine; Division Director, Division of Clinical Pharmacology, Wellcome Professor of Medicine, Wellcome Professor of Pharmacology and Molecular Sc
Internal Medicine
Dr. Theresa A. Shapiro, MD
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Theresa A. Shapiro, MD is an expert in the field of Internal Medicine. She researched medicine at Johns Hopkins University School of Medicine. Johns Hopkins University School of Medicine is a one of the best medicals schools. Johns Hopkins University School of Medicine is ranked 3/29 in Research/PrimaryCare. Theresa A. Shapiro, MD is also a published physician. She has 73 publication published. The most recent publication is: Orally active, hydrolytically stable, semisynthetic, antimalarial trioxanes in the artemisinin family.
Publications
- Model System to Define Pharmacokinetic Requirements for Antimalarial Drug Efficacy.
- Paul Stanley Lietman, MD, PhD, 1934-2013.
- Membrane active chelators as novel anti-African trypanosome and anti-malarial drugs.
- Potent antitrypanosomal activities of heat shock protein 90 inhibitors in vitro and in vivo.
- RNA interference of Trypanosoma brucei topoisomerase IB: both subunits are essential.
- Molecular mechanisms of resistance in antimalarial chemotherapy: the unmet challenge.
- Distinct genes encode type II Topoisomerases for the nucleus and mitochondrion in the protozoan parasite Trypanosoma brucei.
- Second generation, orally active, antimalarial, artemisinin-derived trioxane dimers with high stability, efficacy, and anticancer activity.
- Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study.
- Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts.
- Malaria-infected mice are cured by a single dose of novel artemisinin derivatives.
- A mitochondrial topoisomerase IA essential for late theta structure resolution in African trypanosomes.
- Malaria-infected mice are cured by oral administration of new artemisinin derivatives.
- Activity of indenoisoquinolines against African trypanosomes.
- Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells.
- Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo.
- Phase I/II evaluation of the prophylactic antimalarial activity of pafuramidine in healthy volunteers challenged with Plasmodium falciparum sporozoites.
- Malaria-infected mice live until at least day 30 after a new monomeric trioxane combined with mefloquine are administered together in a single low oral dose.
- Unraveling the secrets of regulating mitochondrial DNA replication.
- Newly identified antibacterial compounds are topoisomerase poisons in African trypanosomes.
- The killing of African trypanosomes by ethidium bromide.
- Malaria-infected mice are completely cured by one 6 mg/kg oral dose of a new monomeric trioxane sulfide combined with mefloquine.
- Correction to Malaria-Infected Mice Are Completely Cured by One 6 mg/kg Oral Dose of a New Monomeric Trioxane Sulfide Combined with Mefloquine.
- Orally active, water-soluble antimalarial 3-aryltrioxanes: short synthesis and preclinical efficacy testing in rodents.
- Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds.
- Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy.
- A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic beta-sulfonyl-endoperoxides.
- An unusual type IB topoisomerase from African trypanosomes.
- New chemical and biological aspects of artemisinin-derived trioxane dimers.
- Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans.
- Antitrypanosomal activities of fluoroquinolones with pyrrolidinyl substitutions.
- Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents.
- Antimalarial simplified 3-aryltrioxanes: synthesis and preclinical efficacy/toxicity testing in rodents.
- Further evidence supporting the importance of and the restrictions on a carbon-centered radical for high antimalarial activity of 1,2,4-trioxanes like artemisinin.
- Molecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and Leishmania.
- Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro.
- Orally active antimalarial 3-substituted trioxanes: new synthetic methodology and biological evaluation.
- Design, synthesis, derivatization, and structure-activity relationships of simplified, tricyclic, 1,2,4-trioxane alcohol analogues of the antimalarial artemisinin.
- Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables.
- Orally active, hydrolytically stable, semisynthetic, antimalarial trioxanes in the artemisinin family.
- Antitrypanosomal activity of fluoroquinolones.
- Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers.
- Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans.
- Prophylactic activity of atovaquone against Plasmodium falciparum in humans.
- Drug-promoted cleavage of kinetoplast DNA minicircles. Evidence for type II topoisomerase activity in trypanosome mitochondria.
- Selective cleavage of kinetoplast DNA minicircles promoted by antitrypanosomal drugs.
- Antimalarial sulfide, sulfone, and sulfonamide trioxanes.
- Antimalarial cyclic peroxy ketals.
- A knotted free minicircle in kinetoplast DNA.
- Synthesis and in vitro antimalarial activity of sulfone endoperoxides.
- Drug cytotoxicity assay for African trypanosomes and Leishmania species.
- Antitrypanosomal activities of tryptanthrins.
- Effects of camptothecin, a topoisomerase I inhibitor, on Plasmodium falciparum.
- Clinical evaluation of amoscanate in healthy male volunteers.
- The structure and replication of kinetoplast DNA.
- Immune mimicry in malaria: Plasmodium falciparum secretes a functional histamine-releasing factor homolog in vitro and in vivo.
- Antitrypanosomal activity of camptothecin analogs. Structure-activity correlations.
- DNA topoisomerases as targets for antiprotozoal therapy.
- Replication of kinetoplast DNA in trypanosomes.
- Effects of probenecid on the pharmacokinetics of allopurinol riboside.
- DNA topoisomerases: a new twist for antiparasitic chemotherapy?
- Inhibition of topoisomerases in African trypanosomes.
- Ribonucleotides associated with a gap in newly replicated kinetoplast DNA minicircles from Trypanosoma equiperdum.
- Mitochondrial topoisomerase II activity is essential for kinetoplast DNA minicircle segregation.
- In vivo inhibition of trypanosome mitochondrial topoisomerase II: effects on kinetoplast DNA maxicircles.
- Kinetoplast DNA maxicircles: networks within networks.
- Pharmacokinetics and metabolism of allopurinol riboside.
- Isolation of kinetoplast DNA.
- Drugs affecting trypanosome topoisomerases.
- Topoisomerases in kinetoplastids.
- Schistosoma mansoni: inhibition of glucosephosphate isomerase and glycolysis by sugar phosphates.
- Schistosoma mansoni: mechanisms in regulation of glycolysis.
Schools
Johns Hopkins University School of Medicine
Doctors Specialties
- Internal Medicine
Accepted Insurances
Education
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Johns Hopkins University -
Johns Hopkins University School of Medicine
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