Professor, Neurology and Neurological Sciences, Stanford University Medical Center

Neurology

Thomas Rando works in the field of Neurology. He went to Harvard Medical School. Harvard Medical School is a top medical college. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. Thomas Rando is also published. He has 101 publications published. The lastest publication: "Methods for myoblast transplantation.'

Publications

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• A Wnt-TGFβ2 axis induces a fibrogenic program in muscle stem cells from dystrophic mice.
• Geroscience: linking aging to chronic disease.
• Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation.
• The JAK-STAT Pathway is Critical in Ventilator-induced Diaphragm Dysfunction.
• Lineage of origin in rhabdomyosarcoma informs pharmacological response.
• Alive and well? Exploring disease by studying lifespan.
• mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert).
• Stem cells as vehicles for youthful regeneration of aged tissues.
• FOXO3 Promotes Quiescence in Adult Muscle Stem Cells during the Process of Self-Renewal.
• Regenerative medicine: Of fish and men.
• Numb-deficient satellite cells have regeneration and proliferation defects.
• FOXO3 Shares Common Targets with ASCL1 Genome-wide and Inhibits ASCL1-Dependent Neurogenesis.
• Cardiac aging and rejuvenation--a sense of humors?
• Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging.
• Molecular regulation of stem cell quiescence.
• The mortal strand hypothesis: Non-random chromosome inheritance and the biased segregation of damaged DNA.
• Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration.
• Myf5 expression during fetal myogenesis defines the developmental progenitors of adult satellite cells.
• Heterochronic Parabiosis: Historical Perspective and Methodological Considerations for Studies of Aging and Longevity.
• The ins and outs of aging and longevity.
• All's well that ends well: alternative polyadenylation and its implications for stem cell biology.
• Recent advances in the pathogenesis and treatment of neuromuscular diseases.
• Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches.
• Notch Signaling is Necessary to Maintain Quiescence in Adult Muscle Stem Cells.
• Manifestations and mechanisms of stem cell aging.
• Taf1 regulates Pax3 protein by monoubiquitination in skeletal muscle progenitors.
• Impact papers on aging in 2009.
• BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration.
• Biomarker system for studying muscle, stem cells, and cancer in vivo.
• Focal adhesion kinase signaling regulates the expression of caveolin 3 and beta1 integrin, genes essential for normal myoblast fusion.
• Turning back time: reversing tissue pathology to enhance stem cell engraftment.
• A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis.
• Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis.
• Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors.
• The immortal strand hypothesis: segregation and reconstruction.
• High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny.
• Intrinsic changes and extrinsic influences of myogenic stem cell function during aging.
• Altered caveolin-3 expression disrupts PI(3) kinase signaling leading to death of cultured muscle cells.
• Prognostic value of telomere length: the long and short of it.
• Long-term increase in mVEGF164 in mouse hindlimb muscle mediated by phage phiC31 integrase after nonviral DNA delivery.
• Focal adhesion kinase is essential for costamerogenesis in cultured skeletal muscle cells.
• Enhancement of plasmid-mediated gene therapy for muscular dystrophy by directed plasmid integration.
• The adult muscle stem cell comes of age.
• NF90 regulates cell cycle exit and terminal myogenic differentiation by direct binding to the 3'-untranslated region of MyoD and p21WAF1/CIP1 mRNAs.
• Aging, stem cells and tissue regeneration: lessons from muscle.
• Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle.
• Artificial sweeteners--enhancing glycosylation to treat muscular dystrophies.
• Notch-mediated restoration of regenerative potential to aged muscle.
• Late-onset distal muscular dystrophy affecting the posterior calves.
• Remarkable preservation of undigested muscle tissue within a Late Cretaceous tyrannosaurid coprolite from Alberta, Canada.
• The regulation of catalase gene expression in mouse muscle cells is dependent on the CCAAT-binding factor NF-Y.
• Oxidative stress and the pathogenesis of muscular dystrophies.
• The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis.
• The modulation of cellular susceptibility to oxidative stress: protective and destructive actions of Cu,Zn-superoxide dismutase.
• Dystrophin gene repair in mdx muscle precursor cells in vitro and in vivo mediated by RNA-DNA chimeric oligonucleotides.
• Gene delivery to muscle.
• Maintenance of muscle stem-cell quiescence by microRNA-489.
• Heterogeneity in the muscle satellite cell population.
• Stem cell ageing and non-random chromosome segregation.
• Emerging models and paradigms for stem cell ageing.
• The ageing systemic milieu negatively regulates neurogenesis and cognitive function.
• Enhanced gene repair mediated by methyl-CpG-modified single-stranded oligonucleotides.
• Epigenetics and aging.
• Stem cell review series: aging of the skeletal muscle stem cell niche.
• Tissue ageing: do insights into molecular mechanisms of ageing lead to new therapeutic strategies?
• [Proteasomal degradation of Pax3 in skeletal muscle progenitors: one ubiquitin does the trick!].
• Technology insight: therapy for Duchenne muscular dystrophy-an opportunity for personalized medicine?
• Get personal with gene therapy for muscular dystrophy.
• Ageing: from stem to stern.
• Non-viral gene therapy for Duchenne muscular dystrophy: progress and challenges.
• Stem cells, ageing and the quest for immortality.
• The bi-directional translocation of MARCKS between membrane and cytosol regulates integrin-mediated muscle cell spreading.
• The regulation of Notch signaling in muscle stem cell activation and postnatal myogenesis.
• Stem cells in postnatal myogenesis: molecular mechanisms of satellite cell quiescence, activation and replenishment.
• Strand bias in oligonucleotide-mediated dystrophin gene editing.
• Rejuvenation of aged progenitor cells by exposure to a young systemic environment.
• A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes.
• Restoration of dystrophin expression in mdx muscle cells by chimeraplast-mediated exon skipping.
• Sequential activation of individual PKC isozymes in integrin-mediated muscle cell spreading: a role for MARCKS in an integrin signaling pathway.
• Oligonucleotide-mediated gene therapy for muscular dystrophies.
• Activation of an adipogenic program in adult myoblasts with age.
• Spontaneous intracranial hypotension: report of two cases and review of the literature.
• Wolfram syndrome: evidence of a diffuse neurodegenerative disease by magnetic resonance imaging.
• Saxitoxin blocks batrachotoxin-modified sodium channels in the node of Ranvier in a voltage-dependent manner.
• The interaction between the activator agents batrachotoxin and veratridine and the gating processes of neuronal sodium channels.
• Inhibition of dystroglycan binding to laminin disrupts the PI3K/AKT pathway and survival signaling in muscle cells.
• Rapid and slow gating of veratridine-modified sodium channels in frog myelinated nerve.
• Anticipatory grief: the term is a misnomer but the phenomenon exists.
• The unrecognized impact of sudden death in terminal illness and in positively progressing convalescence.
• An investigation of grief and adaptation in parents whose children have died from cancer.
• Localization of neurons in the rat spinal cord which project to the superior cervical ganglion.
• Tumor suppression by RNA from the 3' untranslated region of alpha-tropomyosin.
• The fate of myoblasts following transplantation into mature muscle.
• Transient immunosuppressive treatment leads to long-term retention of allogeneic myoblasts in hybrid myofibers.
• Pseudochoreoathetosis. Movements associated with loss of proprioception.
• Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy.
• Tetracycline-regulated gene expression following direct gene transfer into mouse skeletal muscle.
• Genetic analysis of alpha 4 integrin functions in the development of mouse skeletal muscle.
• Myoblast-mediated expression of colony stimulating factor-1 (CSF-1) in the cytokine-deficient op/op mouse.
• Methods for myoblast transplantation.

Schools

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• Harvard Medical School

• Massachusetts General Hospital

Doctors Specialties

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• Neurology

Accepted Insurances

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• Choice Plus POS II
• Great West Healthcare-Cigna PPO
• Individual and Family PPO

Education

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• UCSF Medical Center
• Harvard Medical School

Hospital

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• Stanford Health Care
• VA Palo Alto Health Care System

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