Physician

Internal Medicine

Thomas Ruppert works in the field of Internal Medicine. He went to medical school at Northwestern University Feinberg School of Medicine. Northwestern University Feinberg School of Medicine has a rank of 19 in research and a 29 in primary care Dr. Thomas J. Ruppert is also a published doctor. He has 68 paper published. The most recent paper is: Determination of albumin adducts of (+)-anti-benzo[a]pyrene-diol-epoxide using an high-performance liquid chromatographic column switching technique for sample prepara...

Publications

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• Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer.
• The murine cytomegalovirus pp89 immunodominant H-2Ld epitope is generated and translocated into the endoplasmic reticulum as an 11-mer precursor peptide.
• Subtypes of 20S proteasomes from skeletal muscle.
• Different proteasome subtypes in a single tissue exhibit different enzymatic properties.
• Macrophages escape inhibition of major histocompatibility complex class I-dependent antigen presentation by cytomegalovirus.
• MHC class I antigen processing of an adenovirus CTL epitope is linked to the levels of immunoproteasomes in infected cells.
• Efficient generation of a hepatitis B virus cytotoxic T lymphocyte epitope requires the structural features of immunoproteasomes.
• Impact of skill and experience of the endoscopist on the outcome of endoscopic sphincterotomy techniques.
• Autoxidation of amyloid precursor protein and formation of reactive oxygen species.
• Determination of albumin adducts of (+)-anti-benzo[a]pyrene-diol-epoxide using an high-performance liquid chromatographic column switching technique for sample prepara...
• Safety and efficacy of pancreatic sphincterotomy in chronic pancreatitis.
• The sequence alteration associated with a mutational hotspot in p53 protects cells from lysis by cytotoxic T lymphocytes specific for a flanking peptide epitope.
• The making of the dominant MHC class I ligand SYFPEITHI.
• Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide.
• Inactivation of a defined active site in the mouse 20S proteasome complex enhances major histocompatibility complex class I antigen presentation of a murine cytomegalo...
• Benefits and risks of needle-knife papillotomy.
• Reactive oxygen species and Alzheimer''s disease.
• trans,trans-muconic acid as a biomarker of non-occupational environmental exposure to benzene.
• IFN-gamma is a prerequisite for optimal antigen processing of viral peptides in vivo.
• DNA adducts in human placenta in relation to tobacco smoke exposure and plasma antioxidant status.
• A single residue exchange within a viral CTL epitope alters proteasome-mediated degradation resulting in lack of antigen presentation.
• Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligands.
• Urinary mutagenicity and thioethers in nonsmokers: role of environmental tobacco smoke (ETS) and diet.
• The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)
• Restoration of cytomegalovirus antigen presentation by gamma interferon combats viral escape.
• Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes.
• Acute effects of smoking and high experimental exposure to environmental tobacco smoke (ETS) on the immune system.
• [20 years of endoscopic papillotomy. Analysis of 2752 patients at Erlangen Hospital].
• Elongated peptides, not the predicted nonapeptide stimulate a major histocompatibility complex class I-restricted cytotoxic T lymphocyte clone with specificity for a b...
• Determination of urinary trans,trans-muconic acid by gas chromatography-mass spectrometry.
• The interferon-gamma-inducible 11 S regulator (PA28) and the LMP2/LMP7 subunits govern the peptide production by the 20 S proteasome in vitro.
• The cleavage preference of the proteasome governs the yield of antigenic peptides.
• Selective isoactin release from cultured embryonic skeletal muscle cells.
• Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein.
• Spiperone binding in lymphocytes: part of a dopamine uptake system?
• Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi comp...
• The NCI/CIT microArray database (mAdb) system - bioinformatics for the management and analysis of Affymetrix and spotted gene expression microarrays.
• Analysis of proteins in the spent culture medium of Lupinus albus by electrospray ionisation tandem mass spectrometry.
• The roles of intersubunit interactions in exosome stability.
• Protein-protein cross-linking in the use of the eukaryotic eGST-fusion system.
• Evidence for a copper-binding superfamily of the amyloid precursor protein.
• Link between organ-specific antigen processing by 20S proteasomes and CD8(+) T cell-mediated autoimmunity.
• Intramembrane cleavage of microneme proteins at the surface of the apicomplexan parasite Toxoplasma gondii.
• The glycoprotein gp48 of murine cytomegalovirusL proteasome-dependent cytosolic dislocation and degradation.
• S100A9 is a Biliary Protein Marker of Disease Activity in Primary Sclerosing Cholangitis.
• Enzymes of cysteine synthesis show extensive and conserved modifications patterns that include N(α)-terminal acetylation.
• Analysis of differentially expressed mitochondrial proteins in chromophobe renal cell carcinomas and renal oncocytomas by 2-D gel electrophoresis.
• The role of protein quality control in mitochondrial protein homeostasis under oxidative stress.
• Alkylation of adenosine deaminase and thioredoxin by acrylamide in human cell cultures.
• Mimicking Ndc80 phosphorylation triggers spindle assembly checkpoint signalling.
• The gene mpn310 (hmw2) from Mycoplasma pneumoniae encodes two proteins, HMW2 and HMW2-s, which differ in size but use the same reading frame.
• EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase.
• Analysis of the Arabidopsis O-acetylserine(thiol)lyase gene family demonstrates compartment-specific differences in the regulation of cysteine synthesis.
• Gliotoxin production by clinical and environmental Aspergillus fumigatus strains.
• Candida species fail to produce the immunosuppressive secondary metabolite gliotoxin in vitro.
• Catalytic mechanism of the glutathione peroxidase-type tryparedoxin peroxidase of Trypanosoma brucei.
• The Drosophila mitotic inhibitor Frühstart specifically binds to the hydrophobic patch of cyclins.
• Glutathionylation of trypanosomal thiol redox proteins.
• Deletion of the gliP gene of Aspergillus fumigatus results in loss of gliotoxin production but has no effect on virulence of the fungus in a low-dose mouse infection m...
• Proteome of Mycoplasma pneumoniae.
• Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake.
• Comparative proteomics of glycosomes from bloodstream form and procyclic culture form Trypanosoma brucei brucei.
• Proteomic analysis of mitochondrial protein turnover: identification of novel substrate proteins of the matrix protease pim1.
• GOME level 1-to-2 data processor version 3.0: a major upgrade of the GOME/ERS-2 total ozone retrieval algorithm.
• Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate.
• Experimental proof for a signal peptidase I like activity in Mycoplasma pneumoniae, but absence of a gene encoding a conserved bacterial type I SPase.
• Hepatitis C virus mutation affects proteasomal epitope processing.

Schools

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• Northwestern Center Feinberg School of Medicine

Doctors Specialties

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• Internal Medicine

Accepted Insurances

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Education

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• Northwestern University Feinberg School of Medicine

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