Physician
Internal Medicine
Dr. Thomas L. Richie, MD
Dr. Thomas L. Richie works in the field of Internal Medicine. Thomas L. Richie, MD is a published doctor and has 100 publications published. The lastest was: 'Chloroquine-resistant Plasmodium vivax in transmigration settlements of West Kalimantan, Indonesia.'
Publications
- Phase 1/2a Trial of Plasmodium vivax Malaria Vaccine Candidate VMP001/AS01B in Malaria-Naive Adults: Safety, Immunogenicity, and Efficacy.
- The March Toward Malaria Vaccines.
- Malaria vaccines getting close to clinical reality.
- HLA class II (DR0401) molecules induce Foxp3+ Treg suppression of B cells in Py17XNL malaria.
- The whole parasite, pre-erythrocytic stage approach to malaria vaccine development: a review.
- First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers.
- Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine.
- Human adenovirus 5-vectored Plasmodium falciparum NMRC-M3V-Ad-PfCA vaccine encoding CSP and AMA1 is safe, well-tolerated and immunogenic but does not protect against c...
- DNA Prime/Adenovirus Boost Malaria Vaccine Encoding P. falciparum CSP and AMA1 Induces Sterile Protection Associated with Cell-Mediated Immunity.
- A systematic review of safety data reporting in clinical trials of vaccines against malaria, tuberculosis, and human immunodeficiency virus.
- Use of adenovirus serotype 5 vaccine vectors in seropositive, uncircumcised men: safety lessons from the step trial.
- Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plas...
- Modification of ad5 hexon hypervariable regions circumvents pre-existing ad5 neutralizing antibodies and induces protective immune responses.
- Etiology of acute, non-malaria, febrile illnesses in jayapura, northeastern papua, indonesia.
- Early transcriptional responses of HepG2-A16 liver cells to infection by Plasmodium falciparum sporozoites.
- Sterile protective immunity to malaria is associated with a panel of novel P. falciparum antigens.
- Protective immunity to pre-erythrocytic stage malaria.
- Consistent safety and infectivity in sporozoite challenge model of Plasmodium vivax in malaria-naive human volunteers.
- Immune responses and protection of Aotus monkeys immunized with irradiated Plasmodium vivax sporozoites.
- Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adults.
- Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP component.
- Expression of HLA Class II Molecules in Humanized NOD.Rag1KO.IL2RgcKO Mice Is Critical for Development and Function of Human T and B Cells.
- Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria.
- Molecular vaccines for malaria.
- Genetically attenuated parasite vaccines induce contact-dependent CD8+ T cell killing of Plasmodium yoelii liver stage-infected hepatocytes.
- Inhibitory antibodies specific for the 19-kilodalton fragment of merozoite surface protein 1 do not correlate with delayed appearance of infection with Plasmodium falc...
- Sterile protection against Plasmodium knowlesi in rhesus monkeys from a malaria vaccine: comparison of heterologous prime boost strategies.
- Acquisition of invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein 1 in a transmigrant population requires multiple infections.
- Safety and clinical outcome of experimental challenge of human volunteers with Plasmodium falciparum-infected mosquitoes: an update.
- Characterization of immune reactivity profiles using microarray technology may expedite identification of candidate antigens for next generation malaria vaccines.
- Protection of rhesus monkeys by a DNA prime/poxvirus boost malaria vaccine depends on optimal DNA priming and inclusion of blood stage antigens.
- Boosting of DNA vaccine-elicited gamma interferon responses in humans by exposure to malaria parasites.
- Update on the clinical development of candidate malaria vaccines.
- Associations between responses to the rhoptry-associated membrane antigen of Plasmodium falciparum and immunity to malaria infection.
- Induction in humans of CD8+ and CD4+ T cell and antibody responses by sequential immunization with malaria DNA and recombinant protein.
- Tolerability of azithromycin as malaria prophylaxis in adults in northeast papua, indonesia.
- Safety, tolerability, and lack of antibody responses after administration of a PfCSP DNA malaria vaccine via needle or needle-free jet injection, and comparison of int...
- Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites.
- Humanized HLA-DR4.RagKO.IL2RγcKO.NOD (DRAG) mice sustain the complex vertebrate life cycle of Plasmodium falciparum malaria.
- Sterile Immunity to Malaria after DNA Prime/Adenovirus Boost Immunization Is Associated with Effector Memory CD8+T Cells Targeting AMA1 Class I Epitopes.
- A Glycolipid Adjuvant, 7DW8-5, Enhances CD8+ T Cell Responses Induced by an Adenovirus-Vectored Malaria Vaccine in Non-Human Primates.
- Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP).
- Identification of two new protective pre-erythrocytic malaria vaccine antigen candidates.
- Live attenuated malaria vaccine designed to protect through hepatic CD8? T cell immunity.
- Viral vectors in malaria vaccine development.
- Report of a consultation on the optimization of clinical challenge trials for evaluation of candidate blood stage malaria vaccines, 18-19 March 2009, Bethesda, MD, USA.
- Effect on antibody and T-cell responses of mixing five GMP-produced DNA plasmids and administration with plasmid expressing GM-CSF.
- Induction of CD4(+) T cell-dependent CD8(+) type 1 responses in humans by a malaria DNA vaccine.
- Chloroquine/doxycycline combination versus chloroquine alone, and doxycycline alone for the treatment of Plasmodium falciparum and Plasmodium vivax malaria in northeas...
- Naturally acquired antibody responses to Plasmodium falciparum merozoite surface protein 4 in a population living in an area of endemicity in Vietnam.
- Antibody responses to infections with strains of Plasmodium falciparum expressing diverse forms of merozoite surface protein 2.
- Plasmodium falciparum mdr1 mutations and in vivo chloroquine resistance in Indonesia.
- In vivo responses to antimalarials by Plasmodium falciparum and Plasmodium vivax from isolated Gag Island off northwest Irian Jaya, Indonesia.
- Malaria prophylaxis using azithromycin: a double-blind, placebo-controlled trial in Irian Jaya, Indonesia.
- Chloroquine-resistant Plasmodium vivax in transmigration settlements of West Kalimantan, Indonesia.
- Comparative performance of the ParaSight F test for detection of Plasmodium falciparum in malaria-immune and nonimmune populations in Irian Jaya, Indonesia.
- Lymphocyte response to tetanus toxoid among Indonesian men immunized with tetanus-diphtheria during extended chloroquine or primaquine prophylaxis.
- Mefloquine compared with doxycycline for the prophylaxis of malaria in Indonesian soldiers. A randomized, double-blind, placebo-controlled trial.
- Lymphocyte proliferative response and subset profiles during extended periods of chloroquine or primaquine prophylaxis.
- Halofantrine and primaquine for radical cure of malaria in Irian Jaya, Indonesia.
- Survey of in vivo sensitivity to chloroquine by Plasmodium falciparum and P. vivax in Lombok, Indonesia.
- Malaria in a nonimmune population after extended chloroquine or primaquine prophylaxis.
- The emerging syndrome of envenoming by the New Guinea small-eyed snake Micropechis ikaheka.
- A waterborne outbreak of hepatitis E virus transmission in southwestern Vietnam.
- Malaria field studies at NAMRU-2, Indonesia.
- Molecular cloning of a gene expressed during early embryonic development in Onchocerca volvulus.
- Treatment of chloroquine-resistant Plasmodium vivax with chloroquine and primaquine or halofantrine.
- Primaquine for prophylaxis against malaria among nonimmune transmigrants in Irian Jaya, Indonesia.
- Randomised placebo-controlled trial of primaquine for prophylaxis of falciparum and vivax malaria.
- Natural regulation of rhesus monkey populations in Kathmandu, Nepal. Rhesus monkey groups near Kathmandu, Nepal, show demographic patterns of intrinsic population stab...
- The role of contextual factors in the relationship between physical activity and self-awareness.
- Interactions between malaria parasites infecting the same vertebrate host.
- Surface-associated antigens of Brugia malayi L2 and L3 parasites during vector-stage development.
- High road, low road? Choices and challenges on the pathway to a malaria vaccine.
- A DNA prime-modified vaccinia virus ankara boost vaccine encoding thrombospondin-related adhesion protein but not circumsporozoite protein partially protects healthy m...
- Plasmodium falciparum. Mechanisms of innate and acquired protection against Plasmodium falciparum in Javanese transmigrant adults and children newly resident in malari...
- Primary infection by Plasmodium falciparum or P. vivax in a cohort of Javanese migrants to Indonesian Papua.
- Onset of clinical immunity to Plasmodium falciparum among Javanese migrants to Indonesian Papua.
- Malaria in a cohort of Javanese migrants to Indonesian Papua.
- Utilization of genomic sequence information to develop malaria vaccines.
- Age-dependent impairment of IgG responses to glycosylphosphatidylinositol with equal exposure to Plasmodium falciparum among Javanese migrants to Papua, Indonesia.
- A multilateral effort to develop DNA vaccines against falciparum malaria.
- Progress and challenges for malaria vaccines.
- Assessing the Parasight-F test in northeastern Papua, Indonesia, an area of mixed Plasmodium falciparum and Plasmodium vivax transmission.
- Vaccines against asexual stage malaria parasites.
- Safety, tolerability, and antibody responses in humans after sequential immunization with a PfCSP DNA vaccine followed by the recombinant protein vaccine RTS,S/AS02A.
- Naturally acquired antibody responses to the components of the Plasmodium falciparum merozoite surface protein 1 complex.
- Mefloquine is highly efficacious against chloroquine-resistant Plasmodium vivax malaria and Plasmodium falciparum malaria in Papua, Indonesia.
- Vaxfectin enhances immunogenicity and protective efficacy of P. yoelii circumsporozoite DNA vaccines.
- Malaria vaccines: are we getting closer?
- Malaria vaccines for travelers.
- Immune evasion by malaria parasites: a challenge for vaccine development.
- Changes in the total leukocyte and platelet counts in Papuan and non Papuan adults from northeast Papua infected with acute Plasmodium vivax or uncomplicated Plasmodiu...
- Advances in immunology and vaccine discovery report of the United States-European Commission workshop.
- Vaxfectin enhances both antibody and in vitro T cell responses to each component of a 5-gene Plasmodium falciparum plasmid DNA vaccine mixture administered at low doses.
- Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein.
- The RTS,S malaria vaccine.
- Empowering malaria vaccination by drug administration.
- Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth.
Schools
Perelman School of Medicine University of Pennsylvania
Doctors Specialties
- Infectious Disease Medicine
- Internal Medicine
Accepted Insurances
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