Professor, Dermatology, Uniformed Services University
Dermatology
Dr. Thomas N. Darling, MD
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Thomas Darling practices Dermatology. He attended Duke University School of Medicine. Duke University School of Medicine is a top medical college. Duke University School of Medicine has a rank of 8 in research and a 29 in primary care He over the years received 1 awards: "Fellow (FAAD)". Thomas Darling is a published doctor. He has 78 papers published. The most current publication "Perivascular cells harboring multiple endocrine neoplasia type 1 alterations are neoplastic cells in angiofibromas."
Publications
- Nipple Angiofibromas with Loss of TSC2 Are Associated with Tuberous Sclerosis Complex.
- Improvement of tuberous sclerosis complex (TSC) skin tumors during long-term treatment with oral sirolimus.
- Dermatologic and Dental Aspects of the 2012 International Tuberous Sclerosis Complex Consensus Statements.
- A model system to analyse the ability of human keratinocytes to form hair follicles.
- Clinical delineation and natural history of the PIK3CA-related overgrowth spectrum.
- High frequency of PTEN mutations in nevi and melanomas from xeroderma pigmentosum patients.
- Sun exposure causes somatic second hit mutations and angiofibroma development in Tuberous Sclerosis Complex.
- Sex-specific lung diseases: effect of oestrogen on cultured cells and in animal models.
- Dissociated Human Dermal Papilla Cells Induce Hair Follicle Neogenesis in Grafted Dermal-Epidermal Composites.
- AKT1 Gene Mutation Levels Are Correlated with the Type of Dermatologic Lesions in Patients with Proteus Syndrome.
- Physical, Psychological and Ethical issues in Caring for Individuals with Genetic Skin Disease.
- Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA.
- Antibody microarrays: analysis of cystic fibrosis.
- A Mosaic Activating Mutation in AKT1 Associated with the Proteus Syndrome.
- Recognition of tuberous sclerosis in adult women: delayed presentation with life-threatening consequences.
- Erythropoietin-driven proliferation of cells with mutations in the tumor suppressor gene TSC2.
- Phenotypic characterization of disseminated cells with TSC2 loss of heterozygosity in patients with lymphangioleiomyomatosis.
- Progressive overgrowth of the cerebriform connective tissue nevus in patients with Proteus syndrome.
- Acral lesions in tuberous sclerosis complex: insights into pathogenesis.
- Multiple facial papules and macrocephaly--quiz case. Cowden syndrome (CS).
- Lymphangioleiomyomatosis and TSC2-/- cells.
- Mesenchymal-epithelial interactions involving epiregulin in tuberous sclerosis complex hamartomas.
- Lymphatic involvement in lymphangioleiomyomatosis.
- TSC2 loss in lymphangioleiomyomatosis cells correlated with expression of CD44v6, a molecular determinant of metastasis.
- Oral findings in 58 adults with tuberous sclerosis complex.
- Rapidly growing collagenomas in multiple endocrine neoplasia type I.
- Hitting the mark in hamartoma syndromes.
- MCP-1 overexpressed in tuberous sclerosis lesions acts as a paracrine factor for tumor development.
- Evolution of skin lesions in Proteus syndrome.
- Cutaneous manifestations of proteus syndrome: correlations with general clinical severity.
- Hamartomas and tubers from defects in hamartin-tuberin.
- Simultaneous deficiency in CD28 and STAT6 results in chronic ectoparasite-induced inflammatory skin disease.
- Anti-epiligrin cicatricial pemphigoid: clinical findings, immunopathogenesis, and significant associations.
- The future of academic dermatology in the United States: report on the resident retreat for future physician-scientists, June 15-17, 2001.
- Mucosal morbidity in patients with epidermolysis bullosa acquisita.
- Rapid shape change and release of ninhydrin-positive substances by Leishmania major promastigotes in response to hypo-osmotic stress.
- Changes in the shape of Leishmania major promastigotes in response to hexoses, proline, and hypo-osmotic stress.
- Carbon dioxide abolishes the reverse Pasteur effect in Leishmania major promastigotes.
- Effects of anaerobiosis on adenine nucleotide levels and the release of ATP by Leishmania major promastigotes.
- Metabolic interactions between glucose, glycerol, alanine and acetate in Leishmania braziliensis panamensis promastigotes.
- A comparative study of D-lactate, L-lactate and glycerol formation by four species of Leishmania and by Trypanosoma lewisi and Trypanosoma brucei gambiense.
- D-lactate production by Leishmania braziliensis through the glyoxalase pathway.
- Products of Leishmania braziliensis glucose catabolism: release of D-lactate and, under anaerobic conditions, glycerol.
- In vitro reversible transformation of Leishmania braziliensis panamensis between promastigote and ellipsoidal forms.
- A child with antibodies targeting both linear IgA bullous dermatosis and bullous pemphigoid antigens.
- Treatment of Mycobacterium haemophilum infection with an antibiotic regimen including clarithromycin.
- Acquired cutaneous smooth muscle hamartoma.
- Premature termination codons are present on both alleles of the bullous pemphigoid antigen 2/type XVII collagen gene in five Austrian families with generalized atrophi...
- Multiple facial angiofibromas and collagenomas in patients with multiple endocrine neoplasia type 1.
- American Academy of Dermatology 1997 Awards for Young Investigators in Dermatology. Mutational analysis of the bullous pemphigoid antigen 2/type XVII collagen gene in ...
- Cycloheximide facilitates the identification of aberrant transcripts resulting from a novel splice-site mutation in COL17A1 in a patient with generalized atrophic beni...
- A deletion mutation in COL17A1 in five Austrian families with generalized atrophic benign epidermolysis bullosa represents propagation of an ancestral allele.
- Cutaneous tumors in patients with multiple endocrine neoplasia type 1 show allelic deletion of the MEN1 gene.
- Generalized atrophic benign epidermolysis bullosa.
- Molecular and genetic analysis of disseminated neoplastic cells in lymphangioleiomyomatosis.
- Passive transfer of anti-laminin 5 antibodies induces subepidermal blisters in neonatal mice.
- Lymphangioleiomyomatosis (LAM): molecular insights lead to targeted therapies.
- Birt-Hogg-Dubé syndrome: a novel marker of kidney neoplasia.
- Somatic mutations of the MEN1 tumor suppressor gene detected in sporadic angiofibromas.
- CT of sclerotic bone lesions: imaging features differentiating tuberous sclerosis complex with lymphangioleiomyomatosis from sporadic lymphangioleiomymatosis.
- Histologic variants of periungual fibromas in tuberous sclerosis complex.
- A homozygous deletion mutation in the gene encoding the 180-kDa bullous pemphigoid antigen (BPAG2) in a family with generalized atrophic benign epidermolysis bullosa.
- Cytokeratin 15 expression in central, centrifugal, cicatricial alopecia: new observations in normal and diseased hair follicles.
- De novo biosynthetic profiling of high abundance proteins in cystic fibrosis lung epithelial cells.
- Cytokeratin 75 expression in central, centrifugal, cicatricial alopecia--new observations in normal and diseased hair follicles.
- Protein microarray platforms for clinical proteomics.
- Generalized granuloma annulare in a patient with adult onset diabetes mellitus.
- Phytophotodermatitis: bulla formation and hyperpigmentation during spring break.
- Alteration of skin properties with autologous dermal fibroblasts.
- Human TSC2-null fibroblast-like cells induce hair follicle neogenesis and hamartoma morphogenesis.
- Comprehensive analysis of gene expression profiles in keratinocytes from patients with generalized atrophic benign epidermolysis bullosa.
- Prevalence of tuberous sclerosis complex in Taiwan: a national population-based study.
- Bone marrow-derived keratinocytes are not detected in normal skin and only rarely detected in wounded skin in two different murine models.
- Anti-epiligrin cicatricial pemphigoid and relative risk for cancer.
- Clinical differentiation between Proteus syndrome and hemihyperplasia: description of a distinct form of hemihyperplasia.
- Perivascular cells harboring multiple endocrine neoplasia type 1 alterations are neoplastic cells in angiofibromas.
- Revertant mosaicism: partial correction of a germ-line mutation in COL17A1 by a frame-restoring mutation.
Schools
Duke University
Doctors Specialties
- Dermatology
Accepted Insurances
Awards
- Fellow (FAAD)
Education
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National Institutes of Health Clinical Center -
Duke University Hospital -
University of North Carolina Hospitals -
Duke University School of Medicine
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