Professor, Pediatrics, University of Cincinnati College of Medicine
Pediatrics
Dr. Thomas R. Korfhagen, MD
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Thomas Korfhagen works in the field of Pediatrics. He graduated from University of Cincinnati College of Medicine. Thomas R. Korfhagen, MD has written publications. He has 101 publications published with PubMed. The lastest paper is: 'Enhanced reporter gene expression in cells transfected in the presence of DMI-2, an acid nuclease inhibitor.'
Publications
- Inhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis.
- Foxa3 Induces Goblet Cell Metaplasia and Inhibits Innate Antiviral Immunity.
- Persistence of LPS-induced lung inflammation in surfactant protein-C-deficient mice.
- Rapamycin Decreases Airway Remodeling and Hyperreactivity in a Transgenic Model of Noninflammatory Lung Disease.
- Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma.
- Nitric oxide mediates relative airway hyporesponsiveness to lipopolysaccharide in surfactant protein A-deficient mice.
- Signaling pathways in the epithelial origins of pulmonary fibrosis.
- Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis.
- Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis.
- Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production.
- Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice.
- SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production.
- Surfactant-associated protein B is critical to survival in nickel-induced injury in mice.
- Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection.
- Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice.
- EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis.
- Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production.
- Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.
- Perinatal increases in TGF-{alpha} disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysis.
- SPDEF regulates goblet cell hyperplasia in the airway epithelium.
- Surfactant protein D regulates the cell surface expression of alveolar macrophage beta(2)-integrins.
- Altered postnatal lung development in C3H/HeJ mice.
- Neither SP-A nor NH2-terminal domains of SP-A can substitute for SP-D in regulation of alveolar homeostasis.
- TGF-alpha perturbs surfactant homeostasis in vivo.
- Surfactant protein-D regulates soluble CD14 through matrix metalloproteinase-12.
- The murine SP-C promoter directs type II cell-specific expression in transgenic mice.
- Surfactant protein D influences surfactant ultrastructure and uptake by alveolar type II cells.
- Conditional expression of transforming growth factor-alpha in adult mouse lung causes pulmonary fibrosis.
- Mouse lysozyme M is important in pulmonary host defense against Klebsiella pneumoniae infection.
- Disrupted pulmonary vascular development and pulmonary hypertension in transgenic mice overexpressing transforming growth factor-alpha.
- In vivo measurements of changes in respiratory mechanics with age in mice deficient in surfactant protein D.
- Reversibility of pulmonary abnormalities by conditional replacement of surfactant protein D (SP-D) in vivo.
- The role of pulmonary collectin N-terminal domains in surfactant structure, function, and homeostasis in vivo.
- Surfactant protein A regulates surfactant phospholipid clearance after LPS-induced injury in vivo.
- Dose-related protection from nickel-induced lung injury in transgenic mice expressing human transforming growth factor-alpha.
- Acute lung injury: functional genomics and genetic susceptibility.
- Pulmonary surfactant and inflammation in septic adult mice: role of surfactant protein A.
- Dual Targeting of MEK and PI3K Pathways Attenuates Established and Progressive Pulmonary Fibrosis.
- Functional genomics of oxidant-induced lung injury.
- Surfactant protein A (SP-A)-mediated bacterial clearance: SP-A and cystic fibrosis.
- Overexpression of TGF-alpha increases lung tissue hysteresivity in transgenic mice.
- Surfactant protein D enhances clearance of influenza A virus from the lung in vivo.
- Dose-dependent lung remodeling in transgenic mice expressing transforming growth factor-alpha.
- The collagen-like region of surfactant protein A (SP-A) is required for correction of surfactant structural and functional defects in the SP-A null mouse.
- Surfactant protein D regulates NF-kappa B and matrix metalloproteinase production in alveolar macrophages via oxidant-sensitive pathways.
- Domains of surfactant protein A that affect protein oligomerization, lipid structure and surface tension.
- Altered stability of pulmonary surfactant in SP-C-deficient mice.
- Inhibitory effects of tumor necrosis factor-alpha on cationic lipid-mediated gene delivery to airway cells in vitro.
- Activity of pulmonary surfactant protein-D (SP-D) in vivo is dependent on oligomeric structure.
- Immunosuppressed surfactant protein A-deficient mice have increased susceptibility to Pneumocystis carinii infection.
- Distinct effects of surfactant protein A or D deficiency during bacterial infection on the lung.
- Surfactant metabolism in SP-D gene-targeted mice.
- Tolerance of SP-A-deficient mice to hyperoxia or exercise.
- Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice.
- Human SP-C gene sequences that confer lung epithelium-specific expression in transgenic mice.
- Surfactant-associated protein A inhibits LPS-induced cytokine and nitric oxide production in vivo.
- Pulmonary-specific expression of SP-D corrects pulmonary lipid accumulation in SP-D gene-targeted mice.
- GATA-6 activates transcription of surfactant protein A.
- Attenuation of acute lung injury in transgenic mice expressing human transforming growth factor-alpha.
- Transcriptional regulation of the murine surfactant protein-A gene by B-Myb.
- SP-A enhances viral clearance and inhibits inflammation after pulmonary adenoviral infection.
- Immunolocalization of transforming growth factor alpha and epidermal growth factor receptor in lungs of patients with cystic fibrosis.
- Surfactant protein-A enhances respiratory syncytial virus clearance in vivo.
- Enhanced reporter gene expression in cells transfected in the presence of DMI-2, an acid nuclease inhibitor.
- Surfactant protein-A binds group B streptococcus enhancing phagocytosis and clearance from lungs of surfactant protein-A-deficient mice.
- Surfactant protein A (SP-A) gene targeted mice.
- Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo.
- Surfactant protein-A-deficient mice are susceptible to Pseudomonas aeruginosa infection.
- Characteristics of surfactant from SP-A-deficient mice.
- Postnatal lung function and morphology in transgenic mice expressing transforming growth factor-alpha.
- Transcriptional control in the developing lung. The Parker B. Francis lectureship.
- Surfactant protein A-deficient mice are susceptible to group B streptococcal infection.
- Surfactant metabolism in surfactant protein A-deficient mice.
- Reversal of lung lesions in transgenic transforming growth factor alpha mice by expression of mutant epidermal growth factor receptor.
- Altered surfactant function and structure in SP-A gene targeted mice.
- Regulation of gene transcription in respiratory epithelial cells.
- Transcriptional elements from the human SP-C gene direct expression in the primordial respiratory epithelium of transgenic mice.
- Respiratory epithelial cell expression of human transforming growth factor-alpha induces lung fibrosis in transgenic mice.
- Utilization of modified surfactant-associated protein B for delivery of DNA to airway cells in culture.
- Regulation of gene expression in the lung.
- Transgenic models for study of pulmonary development and disease.
- Lung cell-specific expression of the murine surfactant protein A (SP-A) gene is mediated by interactions between the SP-A promoter and thyroid transcription factor-1.
- Surfactant protein A-polylysine conjugates for delivery of DNA to airway cells in culture.
- Methicillin-resistant Staphylococcus aureus: experience in a general hospital over four years.
- cDNA, deduced polypeptide structure and chromosomal assignment of human pulmonary surfactant proteolipid, SPL(pVal).
- Complete sequence and organization of the murine beta-glucuronidase gene.
- Overlapping transcriptional units on the same strand within the murine beta-glucuronidase gene complex.
- cDNA and deduced amino acid sequence of human pulmonary surfactant-associated proteolipid SPL(Phe).
- DNA sequence variation within the beta-glucuronidase gene complex among inbred strains of mice.
- Two SP-C genes encoding human pulmonary surfactant proteolipid.
- Synthesis and processing of the precursor for human mangano-superoxide dismutase.
- Glucocorticoid enhances surfactant proteolipid Phe and pVal synthesis and RNA in fetal lung.
- Cis-acting sequences from a human surfactant protein gene confer pulmonary-specific gene expression in transgenic mice.
- Structure and expression of the pulmonary surfactant protein SP-C gene in the mouse.
- Genetic element from human surfactant protein SP-C gene confers bronchiolar-alveolar cell specificity in transgenic mice.
- A portion of the human surfactant protein A (SP-A) gene locus consists of a pseudogene.
- Murine pulmonary surfactant SP-A gene: cloning, sequence, and transcriptional activity.
- Chromosomal localization of three pulmonary surfactant protein genes in the mouse.
- Plasmid-mediated resistance to antibiotic synergism in enterococci.
- An explanation for the apparent host specificity of Pseudomonas plasmid R91 expression.
Schools
University of Cincinnati Main Campus
Childrens Hospital Med Center
Doctors Specialties
- Clinical Genetics
- Pediatrics
Accepted Insurances
Education
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Cincinnati Children's Hospital Medical Center -
University of Cincinnati College of Medicine
Hospital
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Cincinnati Children's Hospital Medical Center
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