Physician
Family Medicine
Dr. Thomas S. Edgington, MD
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Thomas S. Edgington, MD is an expert in the field of Family Medicine. He attended Stanford University School of Medicine. Stanford University School of Medicine is a one of the best medicals schools. Stanford University School of Medicine is ranked 2/25 in Research/PrimaryCare. He received 11 awards: "Elected Member", "Fellow", "Rous-Whipple Prize", "Distinguished Career Award", "John A. Lynch Award in Molecular Biology", "Inaugural Address", "The J.W. McLaughlin Award", "The Annual Invited Lecture", "Medal", "Lecturer and Visiting Professor" and "Lilly Award Lecture". Thomas S. Edgington is a published MD. He published 101 publications, including: 'More cellular signals for atherogenesis?'
Publications
- The extrinsic coagulation cascade and tissue factor pathway inhibitor in macrophages: A potential therapeutic opportunity for atherosclerotic thrombosis.
- Dose-Dependent Modulation of Tissue Factor Protein and Procoagulant Activity in Human Monocyte-Derived Macrophages by Oxidized Low Density Lipoprotein.
- Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected].
- Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1.
- Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms.
- A selective tumor microvasculature thrombogen that targets a novel receptor complex in the tumor angiogenic microenvironment.
- Regulation of tissue factor--mediated initiation of the coagulation cascade by cell surface grp78.
- Selective attenuation of the extrinsic limb of the tissue factor-driven coagulation protease cascade by occupancy of a novel peptidyl docking site on tissue factor.
- A novel vascular endothelial growth factor heparin-binding domain substructure binds to glycosaminoglycans in vivo and localizes to tumor microvascular endothelium.
- Prostate-specific membrane antigen directed selective thrombotic infarction of tumors.
- Interaction of fibrinogen with its platelet receptor as part of a multistep reaction in ADP-induced platelet aggregation.
- Subcellular localization of the sedimentable form of mammary tumor glycoprotein to the tumor cell plasmalemma.
- Lymphoid procoagulant activity and mitogenesis in the C3H/HeJ mouse: discordant response to lipopolysaccharide stimulation.
- Lymphocyte cooperation is required for amplification of macrophage procoagulant activity.
- Differences in the characteristics of inhibition of lymphocyte stimulation by 25-hydroxycholesterol and by the immunoregulatory serum lipoprotein LDL-In.
- Immunoregulatory plasma low density lipoprotein: the biologic activity and receptor-binding specificity is independent of neutral lipids.
- Microfilament reorganization is associated with functional activation of alpha M beta 2 on monocytic cells.
- Monoclonal antibody to an activation neoepitope of alpha M beta 2 inhibits multiple alpha M beta 2 functions.
- Two independent sets of monoclonal antibodies define neoepitopes linked to soluble ligand binding and leukocyte adhesion functions of activated alpha M beta 2.
- Integrin regulation of an inflammatory effector gene. Direct induction of the tissue factor promoter by engagement of beta 1 or alpha 4 integrin chains.
- Tissue factor mediates prolonged procoagulant activity on the luminal surface of balloon-injured aortas in rabbits.
- Vascular biology: integrative molecular cell biology.
- Recombinant soluble human tissue factor secreted by Saccharomyces cerevisiae and refolded from Escherichia coli inclusion bodies: glycosylation of mutants, activity an...
- Endotoxin-induced tissue factor messenger RNA in human monocytes is negatively regulated by a cyclic AMP-dependent mechanism.
- The other AIDS crisis.
- Energetic contributions and topographical organization of ligand binding residues of tissue factor.
- Upregulation of human immunodeficiency virus-1 in chronically infected monocytic cell line by both contact with endothelial cells and cytokines.
- Defense.
- NIH funding policy.
- Looking to the future of the life sciences.
- High molecular weight kininogen binds to Mac-1 on neutrophils by its heavy chain (domain 3) and its light chain (domain 5).
- Key ligand interface residues in tissue factor contribute independently to factor VIIa binding.
- Intellectual property rights.
- Integrin regulation of leukocyte inflammatory functions. CD11b/CD18 enhancement of the tumor necrosis factor-alpha responses of monocytes.
- Tissue factor is expressed on monocytes during simulated extracorporeal circulation.
- CD11a/CD18 (LFA-1) integrin engagement enhances biosynthesis of early cytokines by activated T cells.
- Structural biology of tissue factor, the initiator of thrombogenesis in vivo.
- Regulation of tissue factor gene expression in epithelial cells. Induction by serum and phorbol 12-myristate 13-acetate.
- The train has left the station.
- Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees.
- Mutational mapping of functional residues in tissue factor: identification of factor VII recognition determinants in both structural modules of the predicted cytokine ...
- Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemostasis.
- The activation of factor X and prothrombin by recombinant factor VIIa in vivo is mediated by tissue factor.
- Mutational analysis of receptor and cofactor function of tissue factor.
- The serine protease cofactor factor V is synthesized by lymphocytes.
- Tissue Factor residue Asp44 regulates catalytic function of the bound proteinase Factor VIIa.
- Procoagulant activity on injured arteries and associated thrombi is mediated primarily by the complex of tissue factor and factor VIIa.
- Differentiation of adherent human monocytes into macrophages markedly enhances tissue factor protein expression and procoagulant activity.
- Surfing tissue factor. From the predicted to the discovery and elucidation of unanticipated functions and biology of potential significance.
- Prolonged hypercholesterolemia-induced tissue factor expression in rabbit vein grafts: a potential mechanism for graft failure.
- Control of RNA processing by a large non-coding RNA over-expressed in carcinomas.
- Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy.
- Angiostatic therapy gets moving.
- In vivo interrogation of the molecular display of atherosclerotic lesion surfaces.
- Fibrin split products.
- A hybrid fibronectin motif protein as an integrin targeting selective tumor vascular thrombogen.
- Carcinoembryonic Antigen (CEA) in Clinical Diagnosis.
- AN INJECTION TECHNIQUE FOR THE TREATMENT OF FACIAL HEMIATROPHY.
- A recombinant human enzyme for enhanced interstitial transport of therapeutics.
- TETRACYCLINE SPLENOMEGALY IN YOUNG RABBITS.
- A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas.
- More cellular signals for atherogenesis?
- Heterotopic and orthotopic liver transplants in inbred rat strains.
- More inflammatory effects of protease receptors.
- HUMAN BLOOD LYMPHOCYTE CYTOTOXICITY REACTIONS WITH ALLOGENIC ANTISERA.
- Insights in vessel development and vascular disorders using targeted inactivation and transfer of vascular endothelial growth factor, the tissue factor receptor, and t...
- GEL DOUBLE DIFFUSION TESTING FOR TUBERCULOSIS.
- Structure and in vivo behavior of human fibrinogen fragment-D.
- Platelet-induced expression of tissue factor procoagulant activity in freshly isolated human mononuclear cells: implications for experimental use.
- Role of tissue factor in embryonic blood vessel development.
- Comparative reactivities of non-fibrous and fibrous forms of desoxyribonucleoprotein with lupus erythematosus serum.
- Sequential imaging of indium-111-labeled monoclonal antibody in human mammary tumors hosted in nude mice.
- Importance of factor VIIa Gla-domain residue Arg-36 for recognition of the macromolecular substrate factor X Gla-domain.
- Differences in experimental tumor localization of dual-labeled monoclonal antibody.
- Macromolecular substrate affinity for the tissue factor-factor VIIa complex is independent of scissile bond docking.
- Leukaemia inhibitory factor enhances tissue factor expression in human monocyte-derived macrophages: a gp130-mediated mechanism.
- Association between the molecular pathobiology of essential hypertension and thrombotic diseases.
- Dimerization of tissue factor supports solution-phase autoactivation of factor VII without influencing proteolytic activation of factor X.
- So what is critically lacking with coronary atherosclerotic plaques? Perhaps the antithrombotic control.
- Effector cell protease receptor-1 is a vascular receptor for coagulation factor Xa.
- Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature.
- Influence of mutations in tissue factor on the fine specificity of macromolecular substrate activation.
- The structural basis of function of the TF. VIIa complex in the cellular initiation of coagulation.
- Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells. Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors.
- Activation of coagulation and angiogenesis in cancer: immunohistochemical localization in situ of clotting proteins and vascular endothelial growth factor in human can...
- The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.G9 complex.
- Tumor necrosis factor production by human monocytes is a regulated event: induction of TNF-alpha-mediated cellular cytotoxicity by endotoxin.
- Lymphoid procoagulant response to bacterial endotoxin in the rat.
- Tissue factor induction in human monocytes. Two distinct mechanisms displayed by different alloantigen-responsive T cell clones.
- A linkage between the hemostatic and immune systems embodied in the fibrinolytic release of lymphocyte suppressive peptides.
- Heterogeneity of hereditary and acquired factor X deficiencies by combined immunochemical and functional analyses.
- An innate host response to the neoplastic cell: syngeneic rat tumor cells can elicit a rapid de novo lymphoid procoagulant response.
- Intrahepatic expression of serum hepatitis virus-associated antigens.
- Neoantigenic expressions engendered by plasmin cleavage of fibrinogen.
- Molecular events responsible for modulation of neoantigenic expression: the cleavage-associated neoantigen of fibrinogen (blood coagulation-fibrinogen cleavage product...
- Plasma hemopexin levels following aortic valve replacement: a valuable screening test for assessing the severity of cardiac hemolysis.
- Plasma hemopexin homeostasis during the acute phase response.
- Immunobiology of fibrinogen. Emergence of neoantigenic expressions during physiologic cleavage in vitro and in vivo.
- Immunobiology of the autoantibody response. II. The lipoprotein-associated soluble HB erythrocyte autoantigen of NZB mice.
- Immunobiology of the autoantibody response. I. Circulating analogues of erythrocyte autoantigens and heterogeneity of the autoimmune response of NZB mice.
Schools
Stanford University
Hospital Penn
University Of California Los Angeles
Scripps Clin Rsch Fdn
Doctors Specialties
- Immunopathology
- Family Medicine
Accepted Insurances
Awards
- Elected Member
- Fellow
- Rous-Whipple Prize
- Distinguished Career Award
- John A. Lynch Award in Molecular Biology
- Inaugural Address
- The J.W. McLaughlin Award
- The Annual Invited Lecture
- Medal
- Lecturer and Visiting Professor
- Lilly Award Lecture
Education
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Scripps Clinic -
UCLA Medical Center -
Stanford University School of Medicine -
Stanford University
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