Physician
Family Medicine
Dr. Timothy P. Shafer, MD
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Timothy Shafer practices Family Medicine. He graduated from Geisel School of Medicine at Dartmouth. Geisel School of Medicine at Dartmouth has a rank of 37 in research and a 29 in primary care He received 1 awards: "Patient-Centered Medical Home Recognition Program". Dr. Timothy P. Shafer is also published. He has 62 publications published. The lastest publication: "Repeated exposure of adult rats to Aroclor 1254 causes brain region-specific changes in intracellular Ca2+ buffering and protein kinase C activity in the absence of ch...' Timothy Shafer accepts Medicare.
Publications
- Improving in vitro to in vivo extrapolation by incorporating toxicokinetic measurements: A case study of lindane-induced neurotoxicity.
- Glufosinate binds N-methyl-d-aspartate receptors and increases neuronal network activity in vitro.
- Multi-well microelectrode array recordings detect neuroactivity of ToxCast compounds.
- Burst and principal components analyses of MEA data for 16 chemicals describe at least three effects classes.
- Methylmercury effects on ion channels and electrical activity in neurons: future directions.
- Can the mechanisms of aluminum neurotoxicity be integrated into a unified scheme?
- Disruption of inositol phosphate accumulation in cerebellar granule cells by polychlorinated biphenyls: a consequence of altered Ca2+ homeostasis.
- Extracellular calcium is required for the polychlorinated biphenyl-induced increase of intracellular free calcium levels in cerebellar granule cell culture.
- Comments on: ''Perinatal toxicity of cyfluthrin in mice: developmental and behavioral effects'' by Soni and colleagues.
- Mechanisms underlying AlCl3 inhibition of agonist-stimulated inositol phosphate accumulation. Role of calcium, G-proteins, phospholipase C and protein kinase C.
- Effects of aluminum on neuronal signal transduction: mechanisms underlying disruption of phosphoinositide hydrolysis.
- Perturbation by the PCB mixture aroclor 1254 of GABA(A) receptor-mediated calcium and chloride responses during maturation in vitro of rat neocortical cells.
- In vitro exposure to aluminum does not alter long-term potentiation or glutamate release in rat hippocampal slices.
- Polychlorinated biphenyl-stimulation of Ca(2+) oscillations in developing neocortical cells: a role for excitatory transmitters and L-type voltage-sensitive Ca(2+) cha...
- Calcium channels: critical targets of toxicants and diseases.
- Effects of Cd2+, Pb2+ and CH3Hg+ on high voltage-activated calcium currents in pheochromocytoma (PC12) cells: potency, reversibility, interactions with extracellular C...
- Characterization of interactions of methylmercury with Ca2+ channels in synaptosomes and pheochromocytoma cells: radiotracer flux and binding studies.
- Complete inhibition of spontaneous activity in neuronal networks in vitro by deltamethrin and permethrin.
- Differential effects of polychlorinated biphenyl congeners on phosphoinositide hydrolysis and protein kinase C translocation in rat cerebellar granule cells.
- Effects of the chlorotriazine herbicide, cyanazine, on GABA(A) receptors in cortical tissue from rat brain.
- Identification of calcium-dependent and -independent signaling pathways involved in polychlorinated biphenyl-induced cyclic AMP-responsive element-binding protein phos...
- Neurotoxicological outcomes of perinatal heptachlor exposure in the rat.
- Aluminum decreases muscarinic, adrenergic, and metabotropic receptor-stimulated phosphoinositide hydrolysis in hippocampal and cortical slices from rat brain.
- Accumulation of methylmercury or polychlorinated biphenyls in in vitro models of rat neuronal tissue.
- Effects of methylmercury on perineurial Na+ and Ca(2+)-dependent potentials at neuromuscular junctions of the mouse.
- Block of 45Ca uptake into synaptosomes by methylmercury: Ca++- and Na+-dependence.
- Repeated exposure of adult rats to Aroclor 1254 causes brain region-specific changes in intracellular Ca2+ buffering and protein kinase C activity in the absence of ch...
- Inositol 1,4,5-triphosphate receptor-sensitive Ca(2+) release, store-operated Ca(2+) entry, and cAMP responsive element binding protein phosphorylation in developing c...
- Effects of gestational methylmercury exposure on immunoreactivity of specific isoforms of PKC and enzyme activity during post-natal development of the rat brain.
- Inhibition of rat brain phosphatidylinositol-specific phospholipase C by aluminum: regional differences, interactions with aluminum salts, and mechanisms.
- In vitro aluminum inhibition of brain phosphoinositide metabolism: comparison of neonatal and adult rats.
- Development of micro-electrode array based tests for neurotoxicity: assessment of interlaboratory reproducibility with neuroactive chemicals.
- Transmitter, ion channel and receptor properties of pheochromocytoma (PC12) cells: a model for neurotoxicological studies.
- Methylmercury blocks N- and L-type Ca++ channels in nerve growth factor-differentiated pheochromocytoma (PC12) cells.
- Acute toluene exposure alters expression of genes in the central nervous system associated with synaptic structure and function.
- Developing an exposure-dose-response model for the acute neurotoxicity of organic solvents: overview and progress on in vitro models and dosimetry.
- Channelopathies: summary of the hot topic keynotes session.
- Additivity of pyrethroid actions on sodium influx in cerebrocortical neurons in primary culture.
- Toluene inhibits voltage-sensitive calcium channels expressed in pheochromocytoma cells.
- Effects of prolonged exposure to nanomolar concentrations of methylmercury on voltage-sensitive sodium and calcium currents in PC12 cells.
- In vitro assessment of developmental neurotoxicity: use of microelectrode arrays to measure functional changes in neuronal network ontogeny.
- Mechanisms of pyrethroid insecticide-induced stimulation of calcium influx in neocortical neurons.
- Accumulation of pyrethroid compounds in primary cultures from rat cortex.
- Microelectrode arrays: a physiologically based neurotoxicity testing platform for the 21st century.
- Neural progenitor cells as models for high-throughput screens of developmental neurotoxicity: state of the science.
- Development of a high-throughput screening assay for chemical effects on proliferation and viability of immortalized human neural progenitor cells.
- Assessment of chemical effects on neurite outgrowth in PC12 cells using high content screening.
- Developmentally-regulated sodium channel subunits are differentially sensitive to alpha-cyano containing pyrethroids.
- Pyrethroid modulation of spontaneous neuronal excitability and neurotransmission in hippocampal neurons in culture.
- Acute toluene exposure and rat visual function in proportion to momentary brain concentration.
- Concentration-dependent accumulation of [3H]-deltamethrin in sodium channel Nav1.2/beta1 expressing Xenopus laevis oocytes.
- Evaluating the NMDA-glutamate receptor as a site of action for toluene, in vivo.
- Approaches to extrapolating animal toxicity data on organic solvents to public health.
- Permethrin, but not deltamethrin, increases spontaneous glutamate release from hippocampal neurons in culture.
- Role of NMDA, nicotinic, and GABA receptors in the steady-state visual-evoked potential in rats.
- Perturbation of voltage-sensitive Ca2+ channel function by volatile organic solvents.
- Volatile organic compounds inhibit human and rat neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.
- Time and concentration dependent accumulation of [3H]-deltamethrin in Xenopus laevis oocytes.
- Developmental neurotoxicity of pyrethroid insecticides: critical review and future research needs.
- Effects of pyrethroids on voltage-sensitive calcium channels: a critical evaluation of strengths, weaknesses, data needs, and relationship to assessment of cumulative ...
- Ontogeny of voltage-sensitive calcium channel alpha(1A) and alpha(1E) subunit expression and synaptic function in rat central nervous system.
Schools
Dartmouth College
Lancaster Genl Hospital Fp Program
Lancaster General Hospital
Doctors Specialties
- Family Medicine
Accepted Insurances
- Choice Plus POS II
- Blue Card PPO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Commercial Insurance Company
- First Health (Coventry Health Care) PPO
- Harvard Pilgrim Health Care PPO
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- MVP Health Care
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
Awards
- Patient-Centered Medical Home Recognition Program
Education
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Lancaster General Hospital -
Geisel School of Medicine at Dartmouth
Drug Facts
| NPI NUMBER | 1053301721 | |
| NPPES Provider LastName | SHAFER | |
| NPPES Provider FirstName | TIMOTHY | |
| NPPES Provider ZIPCode | 053539724 | |
| NPPES Provider State | VT | |
| Specialty Description | Family Practice | |
| Total Claim Count | 8193.0 | |
| Distinct Opioid Count | 9.0 | |
| Opioid Claim Count | 470.0 | |
| Percent Opioid Claims | 5.74 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1053301721 |
| Last Name Of The Provider | SHAFER |
| First Name Of The Provider | TIMOTHY |
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