Physician
Cardiology
Dr. Toren Finkel, MD
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Toren Finkel, MD practices Cardiology. He received awards:"Elected Member". Toren Finkel is a published doctor and has 100 publications published. The lastest was: 'Mapping of HIV-1 determinants of apoptosis in infected T cells.'
Publications
- Measuring In Vivo Mitophagy.
- Cardiac mitochondria: A surprise about size.
- Unraveling the Truth About Antioxidants: ROS and disease: finding the right balance.
- Aging: The Blurry Line between Life and Death.
- Cellular mechanisms and physiological consequences of redox-dependent signalling.
- Unresolved questions from the analysis of mice lacking MCU expression.
- Mitohormesis.
- Autophagy-Dependent Metabolic Reprogramming Sensitizes TSC2-Deficient Cells to the Antimetabolite 6-Aminonicotinamide.
- The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.
- Key tissue targets responsible for anthrax-toxin-induced lethality.
- Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression.
- Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor.
- Cardiac aging and rejuvenation--a sense of humors?
- Stem cells and oxidants: too little of a bad thing.
- Metabolic regulation of the cell cycle.
- The emerging links between sirtuins and autophagy.
- Chronic parvovirus B19 infection and systemic necrotising vasculitis: opportunistic infection or aetiological agent?
- Indirect mechanisms of HIV pathogenesis: how does HIV kill T cells?
- Vpu increases susceptibility of human immunodeficiency virus type 1-infected cells to fas killing.
- Development and function of autospecific dual TCR+ T lymphocytes.
- Cutting edge: JAK3 activation and rescue of T cells from HIV gp120-induced unresponsiveness.
- Mechanisms of lymphocyte killing by HIV.
- Triggering through CD40 promotes interleukin-4-induced CD23 production and enhanced soluble CD23 release in atopic disease.
- pp56Lck mediates TCR zeta-chain binding to the microfilament cytoskeleton.
- T-cell development and transmembrane signaling: changing biological responses through an unchanging receptor.
- HIV-1 NL4-3, but not IIIB, inhibits JAK3/STAT5 activation in CD4(+) T cells.
- Parvovirus B19-associated interstitial lung disease, hepatitis, and myositis.
- Priming of neutrophils and macrophages for enhanced release of superoxide anion by the calcium ionophore ionomycin. Implications for regulation of the respiratory burst.
- Potential use of a caspase against HIV.
- Developmental regulation of the TCR zeta-chain. Differential expression and tyrosine phosphorylation of the TCR zeta-chain in resting immature and mature T lymphocytes.
- Association of toxic shock syndrome toxin-secreting and exfoliative toxin-secreting Staphylococcus aureus with Kawasaki syndrome complicated by coronary artery disease.
- Thymic development in human CD4 transgenic mice. Positive selection occurs after commitment to the CD8 lineage.
- Altered antigen receptor signaling in anergic T cells from self-tolerant T-cell receptor beta-chain transgenic mice.
- Tyrosine-phosphorylated T cell receptor zeta chain associates with the actin cytoskeleton upon activation of mature T lymphocytes.
- Mapping of HIV-1 determinants of apoptosis in infected T cells.
- The thymus has two functionally distinct populations of immature alpha beta + T cells: one population is deleted by ligation of alpha beta TCR.
- Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes.
- Surface expression of a T cell receptor beta (TCR-beta) chain in the absence of TCR-alpha, -delta, and -gamma proteins.
- Immature thymocytes are protected from deletion early in ontogeny.
- Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking.
- Ligation of the CD4 receptor induces activation-independent down-regulation of L-selectin.
- ADP-ribosylation of rho by C3 ribosyltransferase inhibits IL-2 production and sustained calcium influx in activated T cells.
- Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.
- BRCA1 is an essential regulator of heart function and survival following myocardial infarction.
- Oxidants, metabolism, and stem cell biology.
- A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells.
- Caenorhabditis elegans UCP4 protein controls complex II-mediated oxidative phosphorylation through succinate transport.
- Signal transduction by mitochondrial oxidants.
- Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent.
- Signal transduction by reactive oxygen species.
- Protection from Obesity and Diabetes by Blockade of TGF-?/Smad3 Signaling.
- Genetic links between circulating cells and cardiovascular risk.
- Telomeres and mitochondrial function.
- Wnt signaling regulates hepatic metabolism.
- Metabolism meets autophagy.
- Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report.
- 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks.
- Impact papers on aging in 2009.
- Breathing lessons: Tor tackles the mitochondria.
- Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy.
- Preview. The Tortoise, the hare, and the FoxO.
- A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency.
- Xanthine oxidoreductase depletion induces renal interstitial fibrosis through aberrant lipid and purine accumulation in renal tubules.
- Recent progress in the biology and physiology of sirtuins.
- The Krebs cycle meets the cell cycle: mitochondria and the G1-S transition.
- The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine.
- Bmi1 regulates mitochondrial function and the DNA damage response pathway.
- Regulation of autophagy by the p300 acetyltransferase.
- Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis.
- A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis.
- SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism.
- Mitochondrial metabolism modulates differentiation and teratoma formation capacity in mouse embryonic stem cells.
- Coordination of mitochondrial bioenergetics with G1 phase cell cycle progression.
- Redox-based regulation of signal transduction: principles, pitfalls, and promises.
- A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.
- Free radicals and senescence.
- The common biology of cancer and ageing.
- Augmented Wnt signaling in a mammalian model of accelerated aging.
- GAPDH and the search for alternative energy.
- TOR and aging: less is more.
- Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity.
- Cancer gets the Chk'ered flag.
- Cell biology: a clean energy programme.
- Mitochondrial signaling, TOR, and life span.
- Intracellular redox regulation by the family of small GTPases.
- Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage.
- The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity.
- Time, tumours and telomeres. Meeting on Cancer and Aging.
- Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma.
- Stem cell aging: what bleach can teach.
- The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism.
- Redox-dependent transcriptional regulation.
- Radical medicine: treating ageing to cure disease.
- Reactive oxygen species as mediators of cellular senescence.
- Effect of a histone deacetylase inhibitor on human cardiac mass.
- Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity.
- Mitochondria, oxidants, and aging.
- SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}.
- Endothelial progenitor cells.
Schools
Harvard Medical School
Doctors Specialties
- Internal Medicine
- Cardiology
Accepted Insurances
Awards
- Elected Member
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