Professor, Neurology, USC School of Medicine
Neurology
Dr. Valerie Askanas, MD
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Dr. Valerie Askanas works in the field of Neurology. Valerie Askanas has written publications. She has 100 publications published with PubMed. The lastest publication is: 'Sporadic inclusion-body myositis and its similarities to Alzheimer disease brain. Recent approaches to diagnosis and pathogenesis, and relation to aging.'
Publications
- Update on neuromuscular diseases: Pathology and molecular pathogenesis.
- Sporadic inclusion-body myositis: A degenerative muscle disease associated with aging, impaired muscle protein homeostasis and abnormal mitophagy.
- Sodium phenylbutyrate reverses lysosomal dysfunction and decreases amyloid-β42 in an in vitro-model of inclusion-body myositis.
- Dysferlin is a newly identified binding partner of AβPP and it co-aggregates with amyloid-β42 within sporadic inclusion-body myositis (s-IBM) muscle fibers.
- Chaperone-mediated autophagy components are upregulated in sporadic inclusion-body myositis muscle fibres.
- Pathogenic Considerations in Sporadic Inclusion-Body Myositis, a Degenerative Muscle Disease Associated With Aging and Abnormalities of Myoproteostasis.
- Three lipoprotein receptors and cholesterol in inclusion-body myositis muscle.
- Presence of BACE1 and BACE2 in muscle fibres of patients with sporadic inclusion-body myositis.
- Novel cytoplasmic immunolocalization of RNA polymerase II in inclusion-body myositis muscle.
- Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication.
- Inclusion-body myositis: newest concepts of pathogenesis and relation to aging and Alzheimer disease.
- Cyclin-dependent kinase 5 colocalizes with phosphorylated tau in human inclusion-body myositis paired-helical filaments and may play a role in tau phosphorylation.
- Mitochondrial DNA variants in inclusion body myositis.
- Novel immunolocalization of alpha-synuclein in human muscle of inclusion-body myositis, regenerating and necrotic muscle fibers, and at neuromuscular junctions.
- Association of active extracellular signal-regulated protein kinase with paired helical filaments of inclusion-body myositis muscle suggests its role in inclusion-body...
- Redox factor-1 in muscle biopsies of patients with inclusion-body myositis.
- Inclusion body myositis, muscle blood vessel and cardiac amyloidosis, and transthyretin Val122Ile allele.
- Paired helical filaments of inclusion-body myositis muscle contain RNA and survival motor neuron protein.
- Cultured inclusion-body myositis muscle fibers do not accumulate beta-amyloid precursor protein and can be innervated.
- Localization of survival motor neuron protein in human apoptotic-like and regenerating muscle fibers, and neuromuscular junctions.
- Sporadic inclusion-body myositis and its similarities to Alzheimer disease brain. Recent approaches to diagnosis and pathogenesis, and relation to aging.
- Does overexpression of betaAPP in aging muscle have a pathogenic role and a relevance to Alzheimer's disease? Clues from inclusion body myositis, cultured human muscle...
- Impaired innervation of cultured human muscle overexpressing betaAPP experimentally and genetically: relevance to inclusion-body myopathies.
- Sporadic inclusion-body myositis and hereditary inclusion-body myopathies: current concepts of diagnosis and pathogenesis.
- Immunolocalization of transcription factor NF-kappaB in inclusion-body myositis muscle and at normal human neuromuscular junctions.
- Sporadic inclusion-body myositis and hereditary inclusion-body myopathies: diseases of oxidative stress and aging?
- Fourteen newly recognized proteins at the human neuromuscular junctions--and their nonjunctional accumulation in inclusion-body myositis.
- Nitric oxide-induced oxidative stress in autosomal recessive and dominant inclusion-body myopathies.
- Light and electron microscopic immunolocalization of presenilin 1 in abnormal muscle fibers of patients with sporadic inclusion-body myositis and autosomal-recessive i...
- Immunolocalization of nitric oxide synthases at the postsynaptic domain of human and rat neuromuscular junctions--light and electron microscopic studies.
- Beta APP gene transfer into cultured human muscle induces inclusion-body myositis aspects.
- New developments in hereditary inclusion body myopathies.
- Increase of nitric oxide synthases and nitrotyrosine in inclusion-body myositis.
- Apolipoprotein E and apolipoprotein E messenger RNA in muscle of inclusion body myositis and myopathies.
- Difference in expression of phosphorylated tau epitopes between sporadic inclusion-body myositis and hereditary inclusion-body myopathies.
- Neurotrophic factors and amyotrophic lateral sclerosis.
- Apolipoprotein E alleles in sporadic inclusion-body myositis and hereditary inclusion-body myopathy.
- Use of anti-neurofilament antibody to identify paired-helical filaments in inclusion-body myositis.
- New advances in the understanding of sporadic inclusion-body myositis and hereditary inclusion-body myopathies.
- Transfer of beta-amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities in cultured normal human muscle.
- Expression of muscle-type phosphorylase in innervated and aneural cultured muscle of patients with myophosphorylase deficiency.
- beta-Amyloid precursor protein mRNA is increased in inclusion-body myositis muscle.
- Strong immunoreactivity of alpha 1-antichymotrypsin co-localizes with beta-amyloid protein and ubiquitin in vacuolated muscle fibers of inclusion-body myositis.
- New organotypic model to culture the entire fetal rat spinal cord.
- Twisted tubulofilaments of inclusion body myositis muscle resemble paired helical filaments of Alzheimer brain and contain hyperphosphorylated tau.
- Prion protein is abnormally accumulated in inclusion-body myositis.
- Prion protein is strongly immunolocalized at the postsynaptic domain of human normal neuromuscular junctions.
- Tropomodulin is highly concentrated at the postsynaptic domain of human and rat neuromuscular junctions.
- Enhanced detection of congo-red-positive amyloid deposits in muscle fibers of inclusion body myositis and brain of Alzheimer's disease using fluorescence technique.
- New advances in inclusion-body myositis.
- Expression of beta-amyloid precursor protein gene is developmentally regulated in human muscle fibers in vivo and in vitro.
- Alpha 1-antichymotrypsin is strongly immunolocalized at normal human and rat neuromuscular junctions.
- Abnormal accumulation of prion protein mRNA in muscle fibers of patients with sporadic inclusion-body myositis and hereditary inclusion-body myopathy.
- Apolipoprotein E immunoreactive deposits in inclusion-body muscle diseases.
- Idiopathic inflammatory myopathies: inclusion-body myositis, polymyositis, and dermatomyositis.
- beta-Amyloid precursor epitopes in muscle fibers of inclusion body myositis.
- Long-term treatment with glucocorticoids increases synthesis and stability of junctional acetylcholine receptors on innervated cultured human muscle.
- Human muscle macrophages express beta-amyloid precursor and prion proteins and their mRNAs.
- Hydrocortisone influences voltage-dependent L-type calcium channels in cultured human skeletal muscle.
- Inclusion body myositis and myopathies.
- Vital-freezing of human muscle cultures for storage and reculture.
- Systemic manifestations of gyrate atrophy of the choroid and retina.
- Ultrastructural and cytochemical characteristics of cultured rat Schwann cells.
- CSF from amyotrophic lateral sclerosis patients applied to motor neurons in culture fails to alter neuron-specific enolase.
- Biochemical and morphological effects of 20,25-diazacholesterol on cultured muscle cells.
- Myosin isoenzymes in cultured human muscle.
- Identification of human thymic epithelial cells with antibodies to thymosin alpha 1 in myasthenia gravis.
- Immunocytochemical localization of thymosin-alpha 1 in thymic epithelial cells of normal and myasthenia gravis patients and in thymic cultures.
- Muscle carnitine deficiency: fatty acid metabolism in cultured fibroblasts and muscle cells.
- Electrophysiologic properties of aneurally cultured muscle from patients with myotonic muscular atrophy.
- Adult-onset acid maltase deficiency. Electrophysiological properties of aneurally cultured muscle.
- Abnormality of cultured muscle and Schwann's cells in familial lipid neuromyopathy. Muscle corrected by neural influence.
- Thyrotropin-releasing hormone enhances choline acetyltransferase and creatine kinase in cultured spinal ventral horn neurons.
- Nature of amyloid deposits in hypernephroma. Immunocytochemical studies in 2 cases associated with amyloid polyneuropathy.
- Single cholinergic receptor channel currents in cultured human muscle.
- Demonstration of 2',3'-cyclic nucleotide 3'-phosphohydrolase in cultured human Schwann cells.
- Lysosomal abnormalities in cultured schwann cells from a patient with peripheral neuropathy and continuous muscle fiber activity.
- Human schwann cells in tissue culture: histochemical and ultrastructural studies.
- Adrenomyeloneuropathy: increased accumulation of very long chain fatty acid in cultured skeletal muscle.
- Fiber types and preclinical changes in chicken muscular dystrophy.
- Structural changes in human and chicken muscular dystrophy.
- Histochemistry of cultured aneural chick muscle. Morphological maturation without differentiation of fiber types.
- Sandwich embedding of multiple layers of muscle tissue culture for serial frozen sectioning.
- Normal and dystrophic chicken muscle at successive stages in tissue culture.
- Histochemical and tissue culture studies of dystrophic and experimentally denervated animal muscle.
- Histochemistry of cultured, embryonic and regenerating rat muscle.
- Acetylcholine receptors and acetylcholinesterase accumulate at the nerve-muscle contacts of de novo grown human monolayer muscle cocultured with fetal rat spinal cord.
- Autosomal dominant syndrome of lipid neuromyopathy with normal carnitine: successful treatment with long-chain fatty-acid-free diet.
- Thyrotropin-releasing hormone enhances motor neuron-evoked contractions of cultured human muscle.
- Cells of neural crest origin as possible models to investigate thyrotropin releasing hormone action in the central nervous system.
- Fibroblast growth factor, epidermal growth factor and insulin exert a neuronal-like influence on acetylcholine receptors in aneurally cultured human muscle.
- Synergistic influence of polypeptide growth factors on cultured human muscle.
- Expression of muscle-gene-specific isozymes of phosphorylase and creatine kinase in innervated cultured human muscle.
- De novo neuromuscular junction formation on human muscle fibres cultured in monolayer and innervated by foetal rat spinal cord: ultrastructural and ultrastructural--cy...
- Human muscle cultured in monolayer and cocultured with fetal rat spinal cord: importance of dorsal root ganglia for achieving successful functional innervation.
- Accumulation of CK-MM is impaired in innervated and contracting cultured muscle fibers of Duchenne muscular dystrophy patients.
- Age-dependent requirements of cultured spinal cord neurons.
- Histoenzymatic profile of human muscle cultured in monolayer and innervated de novo by fetal rat spinal cord.
- Developmental expression of the muscle-specific isozyme of phosphoglycerate mutase in human muscle cultured in monolayer and innervated by fetal rat spinal cord.
Doctors Specialties
- Neurology
Accepted Insurances
Hospital
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Keck Hospital of USC
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