Professor, Medicine-Beth Israel Deaconess Medical Center, Harvard Medical School
Hematology
Dr. Vassiliki A. Boussiotis, MD
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Doctor Vassiliki A. Boussiotis, MD is an expert in the field of Hematology. Doctor Vassiliki A. Boussiotis, MD has written publications. She has 101 publications published with PubMed. The lastest publication is: 'No evidence for MUC 1-induced apoptosis.'
Publications
- BK polyomavirus reactivation after reduced-intensity double umbilical cord blood Cell transplantation.
- The role of the thymus in T Cell immune reconstitution after umbilical cord blood transplantation.
- The role of IL-17-producing Foxp3(+) CD4(+) T cells in inflammatory bowel Disease and colon cancer.
- Vaccination with Dendritic Cell/Tumor Fusions following Autologous Stem Cell Transplant Induces Immunologic and Clinical Responses in Multiple Myeloma Patients.
- RIAM (Rap1-interacting adaptor molecule) regulates complement-dependent phagocytosis.
- PD-1 inhibits T Cell proliferation by upregulating p27 and p15 and suppressing Cdc25A.
- Runx1 and Runx3 Are Involved in the Generation and Function of Highly Suppressive IL-17-Producing T Regulatory Cells.
- Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation.
- Molecular and functional heterogeneity of T regulatory Cells.
- RIAM controls invasion and growth of melanoma Cells.
- IL-1β-mediated signals preferentially drive conversion of regulatory T Cells but not conventional T Cells into IL-17-producing Cells.
- Clearance of CMV viremia and survival after double umbilical cord blood transplantation in adults depends on reconstitution of thymopoiesis.
- Rap1A regulates generation of T regulatory Cells via LFA-1-dependent and LFA-1-independent mechanisms.
- Tob, a member of the APRO family, regulates immunological quiescence and tumor suppression.
- RIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T Cells.
- The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T Cells.
- Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3.
- Umbilical cord blood transplantation: basic biology and clinical challenges to immune reconstitution.
- CD134-allodepletion allows selective elimination of alloreactive human T cells without loss of virus-specific and Leukemia-specific effectors.
- Elevation of intraCellular cyclic AMP in alloreactive CD4(+) T Cells induces alloantigen-specific tolerance that can prevent GVHD lethality in vivo.
- Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes.
- A pathway regulated by Cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T Cell tolerance.
- CD28 costimulation mediates transcription of SKP2 and CKS1, the substrate recognition components of SCFSkp2 ubiquitin ligase that leads p27kip1 to degradation.
- Rap1 regulation of RIAM and Cell adhesion.
- CD4+CD25+ regulatory T-Cell lines from human cord blood have functional and molecular properties of T-Cell anergy.
- Rap1-GTP is a negative regulator of Th Cell function and promotes the generation of CD4+CD103+ regulatory T Cells in vivo.
- Development and validation of a clinical prediction rule for bone marrow involvement in patients with Hodgkin Lymphoma.
- Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics.
- RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion.
- Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell Acute lymphoblastic leukemia cells.
- Combination chemotherapy plus low-dose involved-field radiotherapy for early clinical stage Hodgkin's Lymphoma.
- IL-7-dependent human Leukemia T-cell line as a valuable tool for drug discovery in T-ALL.
- Differential localization and function of ADP-ribosylation factor-6 in anergic human T Cells: a potential marker for their identification.
- cAMP inhibits both Ras and Rap1 activation in primary human T lymphocytes, but only Ras inhibition correlates with blockade of Cell cycle progression.
- Antigen-specific and persistent tuberculin anergy in a cohort of pulmonary tuberculosis patients from rural Cambodia.
- CD28 costimulation mediates down-regulation of p27kip1 and Cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T Cells.
- Blockade of B7/CD28 in mixed lymphocyte reaction cultures results in the generation of alternatively activated macrophages, which suppress T-Cell responses.
- PD-1 alters T-Cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation.
- Prostaglandin E2 promotes survival of naive UCB T Cells via the Wnt/β-catenin pathway and alters immune reconstitution after UCBT.
- Double umbilical cord blood transplantation with reduced intensity conditioning and sirolimus-based GVHD prophylaxis.
- Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.
- Physiologic regulation of central and peripheral T Cell tolerance: lessons for therapeutic applications.
- Active Rap1, a small GTPase that induces malignant transformation of hematopoietic progenitors, localizes in the nucleus and regulates protein expression.
- T Cell anergy and costimulation.
- Control and regulation of peripheral tolerance in allergic inflammatory Disease: therapeutic consequences.
- Interleukin-4 stimulates proliferation and growth of T-cell Acute lymphoblastic leukemia cells by activating mTOR signaling.
- Intrinsic and extrinsic regulation of T lymphocyte quiescence.
- Interleukin-7 in T-cell Acute lymphoblastic leukemia: an extrinsic factor supporting leukemogenesis?
- Common gamma chain-signaling cytokines promote proliferation of T-cell Acute lymphoblastic leukemia.
- Prognostic factors in advanced stage Hodgkin''s Lymphoma: the significance of the number of involved anatomic sites.
- Induction of immunologic tolerance for allogeneic hematopoietic Cell transplantation.
- In vivo formation and repair of O6-methylguanine in human leukocyte DNA after intravenous exposure to dacarbazine.
- Transcription of the tumor necrosis factor alpha gene is rapidly induced by anti-immunoglobulin and blocked by cyclosporin A and FK506 in human B Cells.
- CTLA-4 regulates Cell cycle progression during a primary immune response.
- Tob is a negative regulator of activation that is expressed in anergic and quiescent T Cells.
- Interleukin-7 promotes survival and cell cycle progression of T-cell Acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27(ki...
- Helper T cell anergy: from biochemistry to Cancer pathophysiology and therapeutics.
- CTLA-4 regulates induction of anergy in vivo.
- PD-L2 is a second ligand for PD-1 and inhibits T Cell activation.
- Altered T-Cell receptor + CD28-mediated signaling and blocked Cell cycle progression in interleukin 10 and transforming growth factor-beta-treated alloreactive T Cells...
- Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T Cells.
- IL-10-producing T Cells suppress immune responses in anergic tuberculosis patients.
- EBVD combination chemotherapy plus low dose involved field radiation is a highly effective treatment modality for early stage Hodgkin''s Disease.
- p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes.
- CD28 costimulation mediates T Cell expansion via IL-2-independent and IL-2-dependent regulation of Cell cycle progression.
- Transplantation of anergic histoincompatible bone marrow alloGrafts.
- Bone marrow transplantation for low-grade lymphoma and chronic lymphocytic Leukemia.
- No evidence for MUC 1-induced apoptosis.
- The BB1 monoclonal antibody recognizes both Cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a thir...
- Unbalanced expression of bcl-2 family proteins in follicular Lymphoma: contribution of CD40 signaling in promoting survival.
- Induction of T Cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed Cell death.
- Maintenance of human T Cell anergy: blocking of IL-2 gene transcription by activated Rap1.
- Ex vivo generation of human anti-pre-B Leukemia-specific autologous cytolytic T cells.
- The role of B7-1/B7-2:CD28/CLTA-4 pathways in the prevention of anergy, induction of productive immunity and down-regulation of the immune response.
- Breast Cancer-associated antigen, DF3/MUC1, induces apoptosis of activated human T cells.
- Human CD100, a novel leukocyte semaphorin that promotes B-Cell aggregation and differentiation.
- R24 anti-GD3 ganglioside antibody can induce costimulation and prevent the induction of alloantigen-specific T Cell clonal anergy.
- Differential association of protein tyrosine kinases with the T Cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation.
- Fludarabine monophosphate in refractory B-chronic lymphocytic Leukemia: maintenance may be significant to sustain response.
- Pre-B Acute lymphoblastic leukemia cells may induce T-cell anergy to alloantigen.
- Complete blockade of B7 family-mediated costimulation is necessary to induce human alloantigen-specific anergy: a method to ameliorate Graft-versus-host disease and ex...
- Comparative study of the formation and repair of O6-methylguanine in humans and rodents treated with dacarbazine.
- The critical role of CD28 signalling in the prevention of human T-Cell anergy.
- Malignant disorders of small lymphocytes. Small lymphocytic lymphoma, lymphoplasmacytic lymphoma, and chronic lymphocytic Leukemia: their clinical and laboratory relat...
- Accumulation of O6-methylguanine in human DNA after therapeutic exposure to methylating agents and its relationship with biological effects.
- Clinical approach to lymphadenopathy.
- Influenza virus vaccine in B-Cell chronic lymphocytic leukaemia patients.
- Comparative dosimetry of O6-methylguanine in humans and rodents treated with procarbazine.
- Increased natural antibody activity in sera of patients with malignant non-Hodgkin's Lymphomas containing paraproteins.
- B-cell Lymphoma of large multilobated type: an immunohistochemical study of 8 cases and review of the literature.
- Prevention of T Cell anergy by signaling through the gamma c chain of the IL-2 receptor.
- B7 but not interCellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance.
- CTLA4 mediates antigen-specific apoptosis of human T Cells.
- Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T Cell proliferation.
- B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4.
- Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance.
- CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy.
- Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity.
- Tumor necrosis factor alpha is an autocrine growth factor for normal human B Cells.
- Alternatively spliced CD44 transcripts in diffuse large-cell Lymphomas: characterization and comparison with normal activated B cells and epithelial malignancies.
Schools
National and Kapodistrian University Of Athens
Procedures Preformed
- HPC Transplantation (Stem Cell Transplant)
Conditions Treated
- Acute Leukemia
- Anemia
- Coagulation Disorders (incl. Hemophilia)
- Graft vs Host Disease
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Doctors Specialties
- Medical Oncology
- Oncology
- Hematology
Accepted Insurances
Education
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University of Massachusetts -
University of Athens
Hospital
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Beth Israel Deaconess Medical Center
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1861474215 |
| Last Name Of The Provider | BOUSSIOTIS |
| First Name Of The Provider | VASSILIKI |
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