Professor of Pediatrics and Pharmacy University of California, San Diego
Pediatric Infectious Disease
Dr. Victor F. Nizet, MD
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Victor Nizet works in the field of Pediatric Infectious Disease. He studied medicine at Stanford University School of Medicine. Stanford University School of Medicine is a one of the best medicals schools. Stanford University School of Medicine is ranked 2/25 in Research/PrimaryCare. He received 3 awards: "Fellow", "Elected Member" and "E. Mead Johnson Award for Research in Pediatrics". Victor F. Nizet, MD is a published doctor as well. He has 101 publications published. The latest was: Standard susceptibility testing overlooks potent azithromycin activity and cationic peptide synergy against MDR Stenotrophomonas maltophilia.
Publications
- Penicillin binding protein 1 is important in the compensatory response of Staphylococcus aureus to daptomycin-induced membrane damage and is a potential target for β-l...
- Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14.
- Myeloid HIF-1 Is Protective in Helicobacter pylori-Mediated Gastritis.
- Examining the Use of Ceftaroline in the Treatment of Streptococcus pneumoniae Meningitis with Reference to Human Cathelicidin LL-37.
- Heterogeneity of genetic pathways toward daptomycin nonsusceptibility in Staphylococcus aureus determined by adjunctive antibiotics.
- Hedgehog: linking uracil to innate defense.
- Cationic antimicrobial peptide resistance mechanisms of streptococcal pathogens.
- Mechanisms of group A Streptococcus resistance to reactive oxygen species.
- The stretch responsive microRNA miR-148a-3p is a novel repressor of IKBKB, NF-κB signaling, and inflammatory gene expression in human aortic valve cells.
- Phosphorylation of LC3 by the Hippo Kinases STK3/STK4 Is Essential for Autophagy.
- N-Terminal ArgD Peptides from the Classical Staphylococcus aureus Agr System Have Cytotoxic and Proinflammatory Activities.
- Synthesis of mevalonate- and fluorinated mevalonate prodrugs and their in vitro human plasma stability.
- Singly Modified Amikacin and Tobramycin Derivatives Show Increased rRNA A-Site Binding and Higher Potency against Resistant Bacteria.
- Activation of the stress response in macrophages alters the M1/M2 balance by enhancing bacterial killing and IL-10 expression.
- A Role for Streptococcal Collagen-Like Protein 1 (Scl-1) in M1T1 Group A Streptococcus Resistance to Neutrophil Extracellular Traps.
- The interplay between Siglecs and sialylated pathogens.
- Antimicrobial Salvage Therapy for Persistent Staphylococcal Bacteremia Using Daptomycin Plus Ceftaroline.
- Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus.
- Subterfuge and Sabotage: Evasion of Host Innate Defenses by Invasive Gram-Positive Bacterial Pathogens.
- The classical lancefield antigen of group a streptococcus is a virulence determinant with implications for vaccine design.
- Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus.
- Anthracimycin activity against contemporary methicillin-resistant Staphylococcus aureus.
- Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis.
- Human Cathelicidin LL-37 Resistance and Increased Daptomycin MIC in USA 600 (ST45) Methicillin-resistant Staphylococcus aureus is Associated with Increased Mortality i...
- Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A.
- Phenol Soluble Modulin Variants of Community-Associated Methicillin-Resistant Staphylococcus aureus Captured Using Mass Spectrometry-Based Molecular Networking.
- Group B Streptococcus Engages an Inhibitory Siglec through Sialic Acid Mimicry to Blunt Innate Immune and Inflammatory Responses In Vivo.
- Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus.
- Ceftaroline Restores Daptomycin Activity Against Daptomycin Nonsusceptible Vancomycin Resistant Enterococcus faecium.
- Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates.
- A novel role for the yceGH tellurite resistance genes in the pathogenesis of Bacillus anthracis.
- The fibrinogen-binding M1 protein reduces pharyngeal cell adherence and colonization phenotypes of M1T1 Group A Streptococcus.
- Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules.
- Inducing host protection in pneumococcal sepsis by preactivation of the Ashwell-Morell receptor.
- Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions.
- Neuroscience: Bacteria get on your nerves.
- β-lactam Antibiotics Targeting PBP1 Selectively Enhance Daptomycin Activity against Methicillin-Resistant Staphylococcus aureus.
- HIF-1α influences myeloid cell antigen presentation and response to subcutaneous OVA vaccination.
- Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function.
- Hypoxia potentiates allergen induction of HIF-1?, chemokines, airway inflammation, TGF-?1, and airway remodeling in a mouse model.
- Antibacterial drug leads targeting isoprenoid biosynthesis.
- Methicillin-resistant Staphylococcus aureus bacterial nitric oxide synthase affects antibiotic sensitivity and skin abscess development.
- Elevated serum interleukin-10 at time of hospital admission is predictive of mortality in patients with Staphylococcus aureus bacteremia.
- A Conserved UDP-Glucose Dehydrogenase Encoded outside the hasABC Operon Contributes to Capsule Biogenesis in Group A Streptococcus.
- Regulation of ATG4B Stability by RNF5 Limits Basal Levels of Autophagy and Influences Susceptibility to Bacterial Infection.
- Genotypic and Phenotypic Evaluation of the evolution of high-level daptomycin non-susceptibility in vancomycin-resistant Enterococcus faecium.
- A novel role for the transcription factor HIF-1alpha in the formation of mast cell extracellular traps.
- The Pore-Forming Toxin beta hemolysin/cytolysin Triggers p38 MAPK-Dependent IL-10 Production in Macrophages and Inhibits Innate Immunity.
- Selectively guanidinylated aminoglycosides as antibiotics.
- DNase Sda1 Allows Invasive M1T1 Group A Streptococcus to Prevent TLR9-Dependent Recognition.
- Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes.
- Marinopyrrole Derivatives as Potential Antibiotic Agents against Methicillin-Resistant Staphylococcus aureus (I).
- HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis.
- Specific inactivation of two immunomodulatory SIGLEC genes during human evolution.
- The antibiotic CJ-15,801 is an antimetabolite that hijacks and then inhibits CoA biosynthesis.
- Endoplasmic reticulum protein BI-1 regulates Ca2+-mediated bioenergetics to promote autophagy.
- Large-Scale Validation of the Centor and McIsaac Scores to Predict Group A Streptococcal Pharyngitis.
- Conserved anchorless surface proteins as group A streptococcal vaccine candidates.
- Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry.
- Intracellular Streptococcus pyogenes in human macrophages display an altered gene expression profile.
- Staphylococcus aureus virulence is enhanced by secreted factors that block innate immune defenses.
- Dual dehydrosqualene/squalene synthase inhibitors: leads for innate immune system-based therapeutics.
- Pharmacological inhibition of the ClpXP protease increases bacterial susceptibility to host cathelicidin antimicrobial peptides and cell envelope-active antibiotics.
- Cofactors Required for TLR7- and TLR9-Dependent Innate Immune Responses.
- A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection.
- Importance of Toll-like receptor 9 in host defense against M1T1 group A Streptococcus infections.
- Novel bacterial metabolite merochlorin A demonstrates in vitro activity against multi-drug resistant methicillin-resistant Staphylococcus aureus.
- Ampicillin enhances daptomycin- and cationic host defense peptide-mediated killing of ampicillin- and vancomycin-resistant Enterococcus faecium.
- New insights into the biological effects of anthrax toxins: linking cellular to organismal responses.
- The pore-forming protein Cry5B elicits the pathogenicity of Bacillus sp. against Caenorhabditis elegans.
- Leukocyte inflammatory responses provoked by pneumococcal sialidase.
- Fijimycins A-C, three antibacterial etamycin-class depsipeptides from a marine-derived Streptomyces sp.
- Differential expression and intrachromosomal evolution of the sghC1q genes in zebrafish (Danio rerio).
- Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in streptococcal beta protein.
- Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria.
- Improved diagnostic accuracy of group a streptococcal pharyngitis with use of real-time biosurveillance.
- Molecular insight into invasive group A streptococcal disease.
- Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection.
- Microbial competition between Bacillus subtilis and Staphylococcus aureus monitored by imaging mass spectrometry.
- Anthrax toxin induces macrophage death by p38 MAPK inhibition but leads to inflammasome activation via ATP leakage.
- The FbaB-type fibronectin-binding protein of Streptococcus pyogenes promotes specific invasion into endothelial cells.
- A randomized controlled trial of motavizumab versus palivizumab for the prophylaxis of serious respiratory syncytial virus disease in children with hemodynamically sig...
- Bactericidal kinetics of marine-derived napyradiomycins against contemporary methicillin-resistant Staphylococcus aureus.
- Glycosaminoglycan binding facilitates entry of a bacterial pathogen into central nervous systems.
- Study of the IgG endoglycosidase EndoS in group A streptococcal phagocyte resistance and virulence.
- Use of antistaphylococcal beta-lactams to increase daptomycin activity in eradicating persistent bacteremia due to methicillin-resistant Staphylococcus aureus: role of...
- Pharmacological properties of the marine natural product marinopyrrole A against methicillin-resistant Staphylococcus aureus.
- Total synthesis and biological evaluation of marinopyrrole A and analogues.
- Streptococcal M1 protein constructs a pathological host fibrinogen network.
- Papillation in Bacillus anthracis colonies: a tool for finding new mutators.
- IL-1beta-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKbeta.
- Bacterial pore-forming cytolysins induce neuronal damage in a rat model of neonatal meningitis.
- Statins enhance formation of phagocyte extracellular traps.
- Nuclease expression by Staphylococcus aureus facilitates escape from neutrophil extracellular traps.
- Parameters governing invasive disease propensity of non-M1 serotype group A streptococci.
- Streptococcal inhibitor of complement promotes innate immune resistance phenotypes of invasive M1T1 group A Streptococcus.
- Bacteria and phagocytes: mortal enemies.
- Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst.
- Innate barriers against infection and associated disorders.
- Standard susceptibility testing overlooks potent azithromycin activity and cationic peptide synergy against MDR Stenotrophomonas maltophilia.
Schools
Stanford University
Children39s Hospital
Doctors Specialties
- Pediatric Infectious Disease Medicine
- Pediatric Infectious Disease
Accepted Insurances
Awards
- Fellow
- Elected Member
- E. Mead Johnson Award for Research in Pediatrics
Education
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Boston Children's Hospital -
Stanford University School of Medicine
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