Assistant Professor, Pediatrics-Children's Hospital, Harvard Medical School

Pediatric Hematology & Oncology

W N. Haining, MD is an expert in the field of Pediatric Hematology & Oncology. Haining is also published. He has 32 publications published. The lastest publication: "High-molecular-weight surface-exposed proteins of Haemophilus influenzae mediate binding to macrophages.'

Publications

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• CD39 Expression Identifies Terminally Exhausted CD8+ T Cells.
• Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation.
• The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8(+) T cells.
• Reversal of in situ T cell exhaustion during effective human anti-Leukemia responses to donor lymphocyte infusion.
• Antigen availability determines CD8(+) T cell-dendritic cell interaction kinetics and memory fate decisions.
• Isolation of RNA and the synthesis and amplification of cDNA from antigen-specific T cells for genome-wide expression analysis.
• CD28 costimulation regulates genome-wide effects on alternative splicing.
• Travels in time: Assessing the functional complexity of T cells.
• The numerology of T cell functional diversity.
• Deconvolving heterogeneity in the CD8+ T-cell response to HIV.
• Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load.
• Systems biology of vaccination for seasonal influenza in humans.
• Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults.
• Densely interconnected transcriptional circuits control cell states in human hematopoiesis.
• Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF.
• Integrating genomic signatures for immunologic discovery.
• Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo.
• Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.
• CpG oligodeoxynucleotides alter lymphocyte and dendritic cell trafficking in humans.
• High-throughput gene expression profiling of memory differentiation in primary human T cells.
• Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells.
• Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates.
• Molecular signature of CD8+ T cell exhaustion during chronic viral infection.
• Gene expression profiling identifies BAX-delta as a novel tumor antigen in Acute lymphoblastic leukemia.
• Antigen-specific T-cell memory is preserved in children treated for Acute lymphoblastic leukemia.
• Failure to define window of time for autologous tumor vaccination in patients with newly diagnosed or relapsed Acute lymphoblastic leukemia.
• Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation.
• pH-triggered microparticles for peptide vaccination.
• Adoptive T-cell therapy for B-cell Acute lymphoblastic leukemia: preclinical studies.
• The proapoptotic function of Drosophila Hid is conserved in mammalian cells.
• High-molecular-weight surface-exposed proteins of Haemophilus influenzae mediate binding to macrophages.

Schools

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• University Of Oxford School Of Med

• John Radcliffe Hospital Uk

• Wycombe General Hospital Uk

• Children39s Hospital Boston

• Dana Farber Cancer Institute

Procedures Preformed

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• HPC Transplantation (Stem Cell Transplant)

Conditions Treated

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• Acute Leukemia
• Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)

Doctors Specialties

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• Pediatric Hematology
• Oncology

Accepted Insurances

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• Blue Card PPO
• BlueConnect HMO
• Blue with Managed Care Behavioral Health HMO
• Preferred Blue PPO
• Commercial Insurance Company
• GHI PPO
• Fallon Community Health Plan
• First Health (Coventry Health Care) PPO
• Harvard Pilgrim Health Care PPO
• Choice Care PPO
• Medicare MCR
• MultiPlan PPO
• PHCS Network PPO
• Neighborhood Health Plan
• Network Health
• Tufts PPO
• Choice Plus POS
• Navigate HMO
• Navigate POS
• Options PPO
• United Healthcare

Hospital

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• Brigham and Women's Hospital
• Massachusetts General Hospital
• Dana-Farber Cancer Institute

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