Associate Professor, Comprehensive Cancer Center, Yale University School of Medicine

Oncology

Warren Shlomchik practices Oncology. He went to medical school at Perelman School of Medicine at the University of Pennsylvania. He has 1 awards "Elected Member". Dr. Warren D. Shlomchik is a published physician as well. He has 46 publications published. The latest was: Increased efficiency of liposome-mediated transfection by volume reduction and centrifugation.

Publications

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• Engineering Human Peripheral Blood Stem Cell Grafts that Are Depleted of Naïve T Cells and Retain Functional Pathogen-Specific Memory T Cells.
• AlloGraft outcomes in outbred mice.
• Innate immunity alone is not sufficient for Chronic rejection but predisposes healed allografts to T cell-mediated pathology.
• Mechanisms of antigen presentation to T cells in murine Graft-versus-host disease: cross-presentation and the appearance of cross-presentation.
• Memory T Cells from minor histocompatibility antigen-vaccinated and virus-immune donors improves GVL and immune reconstitution.
• Graft-versus-Leukemia (GVL) against mouse blast-crisis chronic myelogenous Leukemia (BC-CML) and chronic-phase chronic myelogenous Leukemia (CP-CML): shared mechanisms...
• A repertoire-independent and Cell intrinsic defect in murine GVHD induction by effector memory T Cells.
• Enhancing alloreactivity does not restore GVHD induction but augments skin Graft rejection by CD4⁺ effector memory T cells.
• Regulatory T Cells require mammalian target of rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice.
• Langerhans cells are not required for Graft-versus-host disease.
• Graft-versus-host disease is independent of innate signaling pathways triggered by pathogens in host hematopoietic cells.
• A crucial role for host APCs in the induction of donor CD4+CD25+ regulatory T cell-mediated suppression of experimental Graft-versus-host disease.
• Recipient B cells are not required for Graft-versus-host disease induction.
• NK cells delay alloGraft rejection in lymphopenic hosts by downregulating the homeostatic proliferation of CD8+ T cells.
• An innate response to allogeneic nonself mediated by monocytes.
• Central memory CD8+ T cells induce graft-versus-host disease and mediate graft-versus-Leukemia.
• Characterization of a novel gain of function glucocorticoid receptor knock-in mouse.
• MyD88-dependent, superoxide-initiated inflammation is necessary for flow-mediated inward remodeling of conduit arteries.
• Langerhans cells are not required for efficient skin Graft rejection.
• Effects of donor T-cell trafficking and priming site on Graft-versus-host disease induction by naive and memory phenotype CD4 T cells.
• CD8+ but not CD4+ T Cells require cognate interactions with target tissues to mediate GVHD across only minor H antigens, whereas both CD4+ and CD8+ T Cells require dir...
• Effector memory CD4+ T cells mediate graft-versus-Leukemia without inducing graft-versus-host disease.
• Memory T Cells in GVHD and GVL.
• Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans Cells.
• Transplantation's greatest challenges: advances in Chronic graft-versus-host disease.
• Recipient gammadelta T cells in Graft-versus-host disease.
• Epidermal langerhans Cell-deficient mice develop enhanced contact hypersensitivity.
• Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine Chronic graft-versus-host disease: requirements depend on tar...
• Target antigens determine Graft-versus-host disease phenotype.
• Recipient CD4+ T cells that survive irradiation regulate Chronic graft-versus-host disease.
• Donor APCs are required for maximal GVHD but not for GVL.
• Graft-versus-Leukemia in a retrovirally induced murine CML model: mechanisms of T-cell killing.
• Memory CD4+ T cells do not induce Graft-versus-host disease.
• APCs in the liver and spleen recruit activated allogeneic CD8+ T cells to elicit hepatic Graft-versus-host disease.
• Effectiveness of donor natural killer Cell alloreactivity in mismatched hematopoietic transplants.
• The immunobiology of T cell therapies for Leukemias.
• Type I interferons are not critical for skin alloGraft rejection or the generation of donor-specific CD8+ memory T cells.
• Multiphoton intravital microscopy of the transplanted mouse kidney.
• Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing Acute graft-versus-host disease: a model system for the reversal of disease.
• Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem Cells through transcriptional activation of the HOXB4 promoter by upstream stimulating facto...
• Prevention of Graft versus host disease by inactivation of host antigen-presenting cells.
• Increased efficiency of liposome-mediated transfection by volume reduction and centrifugation.
• Antigen presentation in Graft-vs-host disease.
• Diverse expression of overlapping genes: the Drosophila Eip28/29 gene and its upstream neighbors.
• GVL against murine Chronic phase and blast phase CML.

Schools

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• Perelman School of Medicine University of Pennsylvania

• New York HospitalCornell

Procedures Preformed

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• HPC Transplantation (Stem Cell Transplant)

Conditions Treated

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• Acute Leukemia
• Anemia
• Chronic Myeloid Leukemia (CML)
• Deep Vein Thrombosis (DVT)
• View All

Doctors Specialties

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• Hematology
• Medical Oncology
• Oncology

Accepted Insurances

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• Great West Healthcare-Cigna PPO
• Connecticare HMO
• Connecticare POS
• Medicare MCR
• MultiPlan PPO
• Navigate HMO
• United Healthcare

Awards

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• Elected Member

Education

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• University of Pennsylvania Health System
• New York Presbyterian Hospital - Cornell Campus
• Perelman School of Medicine at the University of Pennsylvania

Hospital

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• Yale-New Haven Hospital

Helpful Reviews

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Medicare Facts

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National Provider Identifier [NPI]	1467433854
Last Name Of The Provider	SHLOMCHIK
First Name Of The Provider	WARREN
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