Professor, Pathology and Laboratory Medicine, Perelman School of Medicine
Pathology
Dr. Warren S. Pear, MD
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Doctor Warren S. Pear, MD is an expert in the field of Pathology. He went to University of Rochester School of Medicine and Dentistry. He received awards:"Elected Member". Warren Pear is a published physician. He published 84 publications, including: 'Tribbles in normal and malignant haematopoiesis.' He accepts Medicare payments and is registered with Medicare.gov.
Publications
- Tribbles at the cross-roadsâ¦.
- Tribbles in normal and malignant haematopoiesis.
- Discovery of Biomarkers Predictive of GSI Response in Triple-Negative Breast Cancer and Adenoid Cystic Carcinoma.
- Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia.
- The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells.
- NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers.
- T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1.
- Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals.
- T cell factor 1 is required for group 2 innate lymphoid cell generation.
- Complementary Genomic Screens Identify SERCA as a Therapeutic Target in NOTCH1 Mutated Cancer.
- Divergent effects of supraphysiological Notch signals on leukemia stem cells and hematopoietic stem cells.
- Blockade of notch signaling in muscle stem cells causes muscular dystrophic phenotype and impaired muscle regeneration.
- Notch and PI3K: how is the road traveled?
- Identification of Flt3âºCD150â» myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential.
- Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells.
- RBP-J promotes the maturation of neuronal progenitors.
- Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.
- Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation.
- Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.
- Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding.
- NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network.
- Hooked on Hes: a T-ALL of addiction.
- Notch dimerization is required for leukemogenesis and T-cell development.
- Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia.
- HIV-1 Rev-binding protein accelerates cellular uptake of iron to drive Notch-induced T cell leukemogenesis in mice.
- Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice.
- New roles for Notch in tuberous sclerosis.
- Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.
- Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development.
- Active Notch1 confers a transformed phenotype to primary human melanocytes.
- Menin regulates the function of hematopoietic stem cells and lymphoid progenitors.
- Notch signaling specifies megakaryocyte development from hematopoietic stem cells.
- Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.
- Notch2 paves the way to mast cells by Hes1 and Gata3.
- Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells.
- Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development.
- Tribbles homolog 2 (Trib2) and HoxA9 cooperate to accelerate acute myelogenous leukemia.
- Notch signaling in leukemia.
- Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.
- The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development.
- Notch signaling in vascular smooth muscle cells is required to pattern the cerebral vasculature.
- Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas.
- Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells.
- Notch directly regulates Gata3 expression during T helper 2 cell differentiation.
- Immunology. Keeping a tight leash on Notch.
- Notch activity synergizes with B-cell-receptor and CD40 signaling to enhance B-cell activation.
- Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription.
- An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.
- T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage.
- Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia.
- The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor.
- c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.
- Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1.
- Impaired notch signaling promotes de novo squamous cell carcinoma formation.
- Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms.
- Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation.
- The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.
- Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies.
- Lasting longer without oxygen: The influence of hypoxia on Notch signaling.
- Notch signaling is an important regulator of type 2 immunity.
- Notch signaling controls the generation and differentiation of early T lineage progenitors.
- Notch signaling represses myocardin-induced smooth muscle cell differentiation.
- Regulation of lymphoid development, differentiation, and function by the Notch pathway.
- Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats.
- T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling.
- Notch and T cell malignancy.
- Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.
- Tie2-Cre-induced inactivation of a conditional mutant Nf1 allele in mouse results in a myeloproliferative disorder that models juvenile myelomonocytic leukemia.
- Notch 1 signaling regulates peripheral T cell activation.
- NF-kB inhibitor blocks B cell development at two checkpoints.
- Notch and the immune system.
- Localization of BCR-ABL to F-actin regulates cell adhesion but does not attenuate CML development.
- Notch signaling augments T cell responsiveness by enhancing CD25 expression.
- From the yolk sac to the spleen: New roles for Notch in regulating hematopoiesis.
- Notch signaling in lymphopoiesis.
- Notch and cancer: best to avoid the ups and downs.
- Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.
- Notch signaling in cancer.
- BCR-ABL-induced adhesion defects are tyrosine kinase-independent.
- The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl.
- An invitation to T and more: notch signaling in lymphopoiesis.
- Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling.
- Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.
Schools
University Of Rochester
Brigham and Women39s Hospital
Doctors Specialties
- Clinical Pathology
- Pathology
Accepted Insurances
Awards
- Elected Member
Education
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Brigham and Women's Hospital -
University of Rochester School of Medicine and Dentistry
Hospital
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Hospital of the University of Pennsylvania -
Penn Presbyterian Medical Center
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1740225291 |
| Last Name Of The Provider | PEAR |
| First Name Of The Provider | WARREN |
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