Professor, Medicine, University of Washington School of Medicine
Infectious Disease
Dr. Wayne C. Liles Jr., MD
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Wayne C. Liles Jr., MD practices Infectious Disease. He attended University of Washington School of Medicine. Wayne Liles is a published doctor. He has 101 papers published. The most current publication "Effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) on neutrophil kinetics and function in normal human volunteers." Wayne C. Liles Jr. accepts Medicare.
Publications
- Pretreatment with bone marrow-derived mesenchymal stromal cell-conditioned media confers pulmonary ischemic tolerance.
- System-Wide Mapping of Activated Circuitry in Experimental Systemic Inflammatory Response Syndrome.
- Elevation of Soluble Intercellular Adhesion Molecule-1 Levels, but Not Angiopoietin 2, in the Plasma of Human Immunodeficiency Virus-Infected African Women with Clinic...
- Mesenchymal stromal (stem) cell therapy: an emerging immunomodulatory strategy for the adjunctive treatment of sepsis.
- Endothelial Activation and Dysfunction in the Pathogenesis of Microvascular Obstruction in Severe Malaria - A Viable Target for Therapeutic Adjunctive Intervention.
- Special focus: Endothelial activation/dysfunction.
- Endothelial activation biomarkers increase after HIV-1 acquisition: plasma vascular cell adhesion molecule-1 predicts disease progression.
- Is angiopoietin-2 the key piece in the sepsis puzzle?*.
- Effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) on neutrophil kinetics and function in normal human volunteers.
- Hyper-IgE syndrome is not associated with defects in several candidate toll-like receptor pathway genes.
- Lineage-specific growth factors can compensate for stem and progenitor cell deficiencies at the postprogenitor cell level: an analysis of doubly TPO- and G-CSF recepto...
- Therapeutic use of cytokines to modulate phagocyte function for the treatment of infectious diseases: current status of granulocyte colony-stimulating factor, granuloc...
- Broad-spectrum caspase inhibition paradoxically augments cell death in TNF-alpha -stimulated neutrophils.
- Soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) Is Elevated in Bronchoalveolar Lavage Fluid of Patients with Acute Respiratory Distress Syndrome.
- Granulocyte transfusion therapy for infections in candidates and recipients of HPC transplantation: a comparative analysis of feasibility and outcome for community don...
- Mutant elastase in pathogenesis of cyclic and severe congenital neutropenia.
- Cellular and molecular abnormalities in severe congenital neutropenia predisposing to leukemia.
- The p17 cleaved form of caspase-3 is present within viable macrophages in vitro and in atherosclerotic plaque.
- Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macrophages.
- Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist.
- Differential role of MyD88 in macrophage-mediated responses to opportunistic fungal pathogens.
- Fas and Fas-associated death domain protein regulate monocyte chemoattractant protein-1 expression by human smooth muscle cells through caspase- and calpain-dependent ...
- Sustained lipopolysaccharide-induced lung inflammation in mice is attenuated by functional deficiency of the Fas/Fas ligand system.
- Differential response of human lung epithelial cells to fas-induced apoptosis.
- Prosthetic joint infection due to "Helcococcus pyogenes" [corrected].
- Optimal timing to repopulation of resident alveolar macrophages with donor cells following total body irradiation and bone marrow transplantation in mice.
- Inhaled IFN-gamma for persistent nontuberculous mycobacterial pulmonary disease due to functional IFN-gamma deficiency.
- Vestibular toxic effects induced by once-daily aminoglycoside therapy.
- Blockade of the Fas/FasL system improves pneumococcal clearance from the lungs without preventing dissemination of bacteria to the spleen.
- Role of caspases in death and survival of the plaque macrophage.
- Augmented mobilization and collection of CD34+ hematopoietic cells from normal human volunteers stimulated with granulocyte-colony-stimulating factor by single-dose ad...
- Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist.
- A pharmacokinetic-pharmacodynamic model for the mobilization of CD34+ hematopoietic progenitor cells by AMD3100.
- Chlamydia pneumoniae augments the oxidized low-density lipoprotein-induced death of mouse macrophages by a caspase-independent pathway.
- Effect of Chlamydia pneumoniae on cellular ATP content in mouse macrophages: role of Toll-like receptor 2.
- NADPH oxidase restrains the matrix metalloproteinase activity of macrophages.
- Modulation of lipopolysaccharide-induced gene transcription and promotion of lung injury by mechanical ventilation.
- Fas-mediated acute lung injury requires fas expression on nonmyeloid cells of the lung.
- Effective storage of granulocytes collected by centrifugation leukapheresis from donors stimulated with granulocyte-colony-stimulating factor.
- Computational identification of key biological modules and transcription factors in acute lung injury.
- Mechanical ventilation induces inflammation, lung injury, and extra-pulmonary organ dysfunction in experimental pneumonia.
- Physiological functions of caspases beyond cell death.
- Mechanical ventilation interacts with endotoxemia to induce extrapulmonary organ dysfunction.
- cDNA microarray analysis reveals fundamental differences in the expression profiles of primary human monocytes, monocyte-derived macrophages, and alveolar macrophages.
- Simultaneous host and parasite expression profiling identifies tissue-specific transcriptional programs associated with susceptibility or resistance to experimental ce...
- PSGL-1 and mTOR regulate translation of ROCK-1 and physiological functions of macrophages.
- Fas (CD95) induces macrophage proinflammatory chemokine production via a MyD88-dependent, caspase-independent pathway.
- Gemcitabine-related "pseudocellulitis": report of 2 cases and review of the literature.
- Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1.
- Expression microarray analysis implicates apoptosis and interferon-responsive mechanisms in susceptibility to experimental cerebral malaria.
- Differential constitutive and cytokine-modulated expression of human Toll-like receptors in primary neutrophils, monocytes, and macrophages.
- C5 deficiency and C5a or C5aR blockade protects against cerebral malaria.
- Parasite burden and CD36-mediated sequestration are determinants of acute lung injury in an experimental malaria model.
- Plasmodium falciparum shows transcriptional versatility within the human host.
- Tumor necrosis factor-alpha inhibitor-induced lupus-like syndrome presenting as fever of unknown origin in a liver transplant recipient: case report and concise review...
- Primary cutaneous mucormycosis in a lung transplant recipient: case report and concise review of the literature.
- Leukocytosis and Mobilization of CD34+ Hematopoietic Progenitor Cells by AMD3100, a CXCR4 Antagonist.
- The phagocytes: neutrophils and monocytes.
- Inflammatory pathways in malaria infection: TLRs share the stage with other components of innate immunity.
- Failure of two distinct anti-apoptotic approaches to reduce mortality in experimental cerebral malaria.
- Granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and other immunomodulatory therapies for the treatment of infectious diseases ...
- Noninjurious mechanical ventilation activates a proinflammatory transcriptional program in the lung.
- Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children.
- C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria.
- Rosiglitazone modulates the innate immune response to Plasmodium falciparum infection and improves outcome in experimental cerebral malaria.
- Posaconazole: A new agent for the prevention and management of severe, refractory or invasive fungal infections.
- Mycobacterium tuberculosis Bacteremia in a Cohort of HIV-Infected Patients Hospitalized with Severe Sepsis in Uganda-High Frequency, Low Clinical Sand Derivation of a ...
- Delay in diagnosis: malaria in a returning traveller.
- Use of peroxisome proliferator-activated receptor gamma agonists as adjunctive treatment for Plasmodium falciparum malaria: a randomized, double-blind, placebo-control...
- Delusional parasitosis: six-year experience with 23 consecutive cases at an academic medical center.
- Adenosine triphosphate depletion of erythrocytes simulates the phenotype associated with pyruvate kinase deficiency and confers protection against Plasmodium falciparu...
- Statins fail to improve outcome in experimental cerebral malaria and potentiate Toll-like receptor-mediated cytokine production by murine macrophages.
- Biomarkers of Endothelial Activation Are Associated with Poor Outcome in Critical Illness.
- Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria.
- Establishing an antimicrobial stewardship program.
- Malaria exacerbates experimental mycobacterial infection in vitro and in vivo.
- Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis.
- Fas (CD95) induces rapid, TLR4/IRAK4-dependent release of pro-inflammatory HMGB1 from macrophages.
- Divergent roles of IRAK4-mediated innate immune responses in two experimental models of severe malaria.
- CD36 deficiency attenuates experimental mycobacterial infection.
- Mechanical ventilation modulates Toll-like receptor-3-induced lung inflammation via a MyD88-dependent, TLR4-independent pathway: a controlled animal study.
- Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis.
- Pandemic H1N1 influenza infection and vascular thrombosis.
- A novel tissue-engineered approach to problems of the postpneumonectomy space.
- Combinations of host biomarkers predict mortality among Ugandan children with severe malaria: a retrospective case-control study.
- Endothelial activation and dysregulation in malaria: a potential target for novel therapeutics.
- Endothelial activation, dysfunction and permeability during severe infections.
- Systemic dysregulation of angiopoietin-1/2 in streptococcal toxic shock syndrome.
- Complement activation: a critical mediator of adverse fetal outcomes in placental malaria?
- Hematopoietic Fas deficiency does not affect experimental atherosclerotic lesion formation despite inducing a proatherogenic state.
- S1P is associated with protection in human and experimental cerebral malaria.
- Nitric oxide for the adjunctive treatment of severe malaria: hypothesis and rationale.
- Inhaled nitric oxide for the adjunctive therapy of severe malaria: protocol for a randomized controlled trial.
- Immunomodulatory therapy for severe influenza.
- Immunopathogenesis of falciparum malaria: implications for adjunctive therapy in the management of severe and cerebral malaria.
- Colony-stimulating factors in the prevention and management of infectious diseases.
- Inhaled nitric oxide reduces endothelial activation and parasite accumulation in the brain, and enhances survival in experimental cerebral malaria.
- Performance characteristics of combinations of host biomarkers to identify women with occult placental malaria: a case-control study from Malawi.
- The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice.
- Inhaled nitric oxide therapy fails to improve outcome in experimental severe influenza.
Schools
University of Washington
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
Education
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University of Washington -
Massachusetts General Hospital -
University of Washington School of Medicine
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