Professor of Pediatrics, Boston Children's Hospital
Pediatric Gastroenterology
Dr. Wayne I. Lencer, MD
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Wayne Lencer is an expert in the field of Pediatric Gastroenterology. He researched medicine at Boston University School of Medicine. Boston University School of Medicine is ranked 30/52 in Research/PrimaryCare. He over the years received 2 awards: "Fellow (AGAF)" and "Super Doctor". Wayne Lencer is a published physician as well. He has 101 publications published. The latest was: Mucosal vaccination: "all politics are local".
Publications
- Neonatal Fc Receptor Expression in Dendritic Cells Mediates Protective Immunity against Colorectal Cancer.
- Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeutics.
- Multivalent immune complexes divert FcRn to lysosomes by exclusion from recycling sorting tubules.
- The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling.
- Cross-presentation of IgG-containing immune complexes.
- The immunologic functions of the neonatal Fc receptor for IgG.
- Lipid Sorting by Ceramide Structure from Plasma Membrane to ER for the Cholera Toxin Receptor Ganglioside GM1.
- Eliciting mucosal immunity.
- Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes.
- To translocate or not: that is the problem.
- Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells.
- Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not Derlin-1 or -2.
- Selective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cells.
- N-terminal extension of the cholera toxin A1-chain causes rapid degradation after retrotranslocation from endoplasmic reticulum to cytosol.
- Functional Analysis of VopF Activity Required for Colonization in Vibrio cholerae.
- An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice.
- The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity.
- N-Glycan Moieties in Neonatal Fc Receptor Determine Steady-state Membrane Distribution and Directional Transport of IgG.
- Ceramide activates JNK to inhibit a cAMP-gated K+ conductance and Cl- secretion in intestinal epithelia.
- Patching a leaky intestine.
- Dependence of antibody-mediated presentation of antigen on FcRn.
- Attenuated endocytosis and toxicity of a mutant cholera toxin with decreased ability to cluster ganglioside GM1 molecules.
- Derlin-1 facilitates the retro-translocation of cholera toxin.
- Ca2+-dependent calmodulin binding to FcRn affects immunoglobulin G transport in the transcytotic pathway.
- Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria.
- Protein disulfide isomerase-like proteins play opposing roles during retrotranslocation.
- A biochemical method for tracking cholera toxin transport from plasma membrane to Golgi and endoplasmic reticulum.
- Antibodies in the breakdown lane.
- Role of p97 AAA-ATPase in the retrotranslocation of the cholera toxin A1 chain, a non-ubiquitinated substrate.
- Calnexin and ERp57 facilitate the assembly of the neonatal Fc receptor for IgG with beta 2-microglobulin in the endoplasmic reticulum.
- Signal transduction by bacterial proteins.
- Trafficking of cholera toxin-ganglioside GM1 complex into Golgi and induction of toxicity depend on actin cytoskeleton.
- Cholera toxin toxicity does not require functional Arf6- and dynamin-dependent endocytic pathways.
- Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway.
- Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells.
- Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response.
- Diarrhea-associated HIV-1 APIs potentiate muscarinic activation of Cl- secretion by T84 cells via prolongation of cytosolic Ca2+ signaling.
- Bidirectional transepithelial IgG transport by a strongly polarized basolateral membrane Fcgamma-receptor.
- Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulm.
- Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation.
- Distribution of the IgG Fc receptor, FcRn, in the human fetal intestine.
- Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung.
- Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin.
- Uncoupling of the cholera toxin-G(M1) ganglioside receptor complex from endocytosis, retrograde Golgi trafficking, and downstream signal transduction by depletion of m...
- Cryptdin 3 forms anion selective channels in cytoplasmic membranes of human embryonic kidney cells.
- Research agenda for pediatric gastroenterology, hepatology and nutrition: secretion and diarrhea. Report of the North American Society for Pediatric Gastroenterology, ...
- Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum.
- TorsinA participates in endoplasmic reticulum-associated degradation.
- The zebrafish dag1 mutant: a novel genetic model for dystroglycanopathies.
- Conversion of apical plasma membrane sphingomyelin to ceramide attenuates the intoxication of host cells by cholera toxin.
- Neonatal Fc receptor: from immunity to therapeutics.
- Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn.
- IgG transport across mucosal barriers by neonatal Fc receptor for IgG and mucosal immunity.
- How the controller is controlled - neonatal Fc receptor expression and immunoglobulin G homeostasis.
- Rafting with cholera toxin: endocytosis and trafficking from plasma membrane to ER.
- The HA proteins of botulinum toxin disrupt intestinal epithelial intercellular junctions to increase toxin absorption.
- Entry of protein toxins into mammalian cells by crossing the endoplasmic reticulum membrane: co-opting basic mechanisms of endoplasmic reticulum-associated degradation.
- Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure.
- The Cdc42 inhibitor secramine B prevents cAMP-induced K+ conductance in intestinal epithelial cells.
- Raft trafficking of AB5 subunit bacterial toxins.
- The intracellular voyage of cholera toxin: going retro.
- Mechanism for Adhesion G Protein-Coupled Receptor GPR56-Mediated RhoA Activation Induced By Collagen III Stimulation.
- A passionate kiss, then run: exocytosis and recycling of IgG by FcRn.
- Retrograde transport of cholera toxin into the ER of host cells.
- Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treate...
- Role of ubiquitination in retro-translocation of cholera toxin and escape of cytosolic degradation.
- The heavy chain of neonatal Fc receptor for IgG is sequestered in endoplasmic reticulum by forming oligomers in the absence of beta2-microglobulin association.
- Unionization of house staff.
- Mechanism of cholera toxin action on a polarized human intestinal epithelial cell line: role of vesicular traffic.
- Cl- secretion in a model intestinal epithelium induced by a neutrophil-derived secretagogue.
- FITC-dextran as a probe for endosome function and localization in kidney.
- Endocytic vesicles from renal papilla which retrieve the vasopressin-sensitive water channel do not contain a functional H+ ATPase.
- Endocytosis of water channels in rat kidney: cell specificity and correlation with in vivo antidiuresis.
- [Characterization of proton pump and osmotic water transport in endocytic vesicles from rat kidney proximal tubule].
- Interaction of cholera toxin with cloned human goblet cells in monolayer culture.
- Functional colocalization of water channels and proton pumps in endosomes from kidney proximal tubule.
- Endosomes from kidney collecting tubule cells contain the vasopressin-sensitive water channel.
- Differential binding kinetics of cholera toxin to intestinal microvillus membrane during development.
- Transcytosis of cholera toxin subunits across model human intestinal epithelia.
- Signal transduction by cholera toxin: processing in vesicular compartments does not require acidification.
- Targeting of cholera toxin and Escherichia coli heat labile toxin in polarized epithelia: role of COOH-terminal KDEL.
- Heterologous expression of delta F508 CFTR results in decreased sialylation of membrane glycoconjugates.
- Monoclonal immunoglobulin A antibodies directed against cholera toxin prevent the toxin-induced chloride secretory response and block toxin binding to intestinal epith...
- The A2b adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epithelia.
- Bacterial and host interactions during the biogenesis, toxicity and immunogenicity of Escherichia coli heat-labile enterotoxin.
- Entry of cholera toxin into polarized human intestinal epithelial cells. Identification of an early brefeldin A sensitive event required for A1-peptide generation.
- Carboxy-terminal vesicular stomatitis virus G protein-tagged intestinal Na+-dependent glucose cotransporter (SGLT1): maintenance of surface expression and global trans...
- The antifungal antibiotic, clotrimazole, inhibits Cl- secretion by polarized monolayers of human colonic epithelial cells.
- Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: implications for microbial attachment and oral...
- Surface expression, polarization, and functional significance of CD73 in human intestinal epithelia.
- Proteolytic activation of cholera toxin and Escherichia coli labile toxin by entry into host epithelial cells. Signal transduction by a protease-resistant toxin variant.
- Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3.
- The antifungal antibiotic, clotrimazole, inhibits chloride secretion by human intestinal T84 cells via blockade of distinct basolateral K+ conductances. Demonstration ...
- Acid secretion, ulcer disease, and cell biology.
- Ganglioside structure dictates signal transduction by cholera toxin and association with caveolae-like membrane domains in polarized epithelia.
- Paneth cells: on the front line or in the backfield?
- Distinct Ca2+- and cAMP-dependent anion conductances in the apical membrane of polarized T84 cells.
- The potassium channel and how it works.
- Mucosal vaccination: "all politics are local".
- Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion.
Schools
Boston University School Of Medicine
Boston City Hospital
Chldns Hospital Mass Genl Hospital
Doctors Specialties
- Pediatric Gastroenterology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- BlueConnect HMO
- Blue with Managed Care Behavioral Health HMO
- Preferred Blue PPO
- Great West Healthcare-Cigna PPO
- LocalPlus
- First Health (Coventry Health Care) PPO
- MultiPlan PPO
- PHCS Network PPO
- Tufts PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
Awards
- Fellow (AGAF)
- Super Doctor
Education
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Massachusetts General Hospital -
Boston University Medical Center -
Boston University School of Medicine
Hospital
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Boston Children's Hospital
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