Physician
Infectious Disease
Dr. Willem H. Boom, MD
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Willem H. Boom, MD is an expert in the field of Infectious Disease. He went to medical school at University of Rochester School of Medicine and Dentistry. Willem Boom has written publications. He has 101 publications published with PubMed. The lastest paper is: 'Activation of human CD8+ alpha beta TCR+ cells by Mycobacterium tuberculosis via an alternate class I MHC antigen-processing pathway.' Doctor Willem H. Boom, MD accepts Medicare.
Publications
- Comparison of MGIT and Myco/F Lytic Liquid-Based Blood Culture Systems for Recovery of Mycobacterium tuberculosis from Pleural Fluid.
- TLR2-dependent ERK signaling in Mycobacterium tuberculosis-infected macrophages drives anti-inflammatory responses and inhibits Th1 polarization of responding T cells.
- Polymorphisms in TICAM2 and IL1B are associated with TB.
- Mycobacterium tuberculosis Lipoprotein LprG Binds Lipoarabinomannan and Determines Its Cell Envelope Localization to Control Phagolysosomal Fusion.
- Regulation of mammalian siderophore 2,5-DHBA in the innate immune response to infection.
- Safety and reactogenicity of BCG revaccination with isoniazid pretreatment in TST positive adults.
- How we determined the most reliable solid medium for studying treatment of tuberculosis.
- Contact investigation for active tuberculosis among child contacts in Uganda.
- Comparison of time to positive and colony counting in an early bactericidal activity study of anti-tuberculosis treatment.
- Genetic and Shared Environmental Influences on Interferon-γ Production in Response to Mycobacterium tuberculosis Antigens in a Ugandan Population.
- Clinical and epidemiological characteristics of individuals resistant to M. tuberculosis infection in a longitudinal TB household contact study in Kampala, Uganda.
- Tuberculin Skin Test Reversion following Isoniazid Preventive Therapy Reflects Diversity of Immune Response to Primary Mycobacterium tuberculosis Infection.
- A metabolic biosignature of early response to anti-tuberculosis treatment.
- Mycobacterium tuberculosis Specific CD8(+) T Cells Rapidly Decline with Antituberculosis Treatment.
- Processing of Mycobacterium tuberculosis antigen 85B involves intraphagosomal formation of peptide-major histocompatibility complex II complexes and is inhibited by li...
- CD4(+) and CD8(+) T cells kill intracellular Mycobacterium tuberculosis by a perforin and Fas/Fas ligand-independent mechanism.
- Mycobacterium tuberculosis 19-kDa lipoprotein promotes neutrophil activation.
- Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19-kDa lipoprotein of Mycobacterium tuberculosis.
- Phagocytic processing of antigens for presentation by class II major histocompatibility complex molecules.
- Human natural killer cells mediate killing of intracellular Mycobacterium tuberculosis H37Rv via granule-independent mechanisms.
- Serum interleukin-6 (IL-6), IL-10, tumor necrosis factor (TNF) alpha, soluble type II TNF receptor, and transforming growth factor beta levels in human immunodeficienc...
- Effect of potent antiretroviral therapy on immune responses to Mycobacterium avium in human immunodeficiency virus-infected subjects.
- Latency-associated peptide of transforming growth factor beta enhances mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 mice.
- Mycobacterium tuberculosis inhibits MHC class II antigen processing in murine bone marrow macrophages.
- Gammadelta T cells and Mycobacterium tuberculosis.
- Regulation of human CD4(+) alphabeta T-cell-receptor-positive (TCR(+)) and gammadelta TCR(+) T-cell responses to Mycobacterium tuberculosis by interleukin-10 and trans...
- Phagocytic antigen processing and effects of microbial products on antigen processing and T-cell responses.
- Differential regulation of IFN-gamma, TNF-alpha, and IL-10 production by CD4(+) alphabetaTCR+ T cells and vdelta2(+) gammadelta T cells in response to monocytes infect...
- Activation of human CD8+ alpha beta TCR+ cells by Mycobacterium tuberculosis via an alternate class I MHC antigen-processing pathway.
- Regulation of interleukin-12 by interleukin-10, transforming growth factor-beta, tumor necrosis factor-alpha, and interferon-gamma in human monocytes infected with Myc...
- Tuberculosis vaccines: how close to human testing?
- Flow analysis of MHC molecules and other membrane proteins in isolated phagosomes.
- Differing susceptibilities of mice, guinea pigs and rabbits to Mycobacterium tuberculosis.
- Lymphocyte-dependent inhibition of growth of virulent Mycobacterium tuberculosis H37Rv within human monocytes: requirement for CD4+ T cells in purified protein derivat...
- Processing of Mycobacterium tuberculosis bacilli by human monocytes for CD4+ alphabeta and gammadelta T cells: role of particulate antigen.
- Bacterial antigen activation of Vdelta1 and Vdelta2 gammadelta T cells of persons infected with human immunodeficiency virus type 1.
- Human alveolar T lymphocyte responses to Mycobacterium tuberculosis antigens: role for CD4+ and CD8+ cytotoxic T cells and relative resistance of alveolar macrophages ...
- The role of T-cell subsets in Mycobacterium tuberculosis infection.
- Activation of antigen-induced lymphocyte proliferation by interleukin-15 without the mitogenic effect of interleukin-2 that may induce human immunodeficiency virus-1 e...
- Interleukin-12 production by human monocytes infected with Mycobacterium tuberculosis: role of phagocytosis.
- T cell response to Mycobacterium tuberculosis.
- Brugia malayi: acquired resistance to microfilariae in BALB/c mice correlates with local Th2 responses.
- Modulation of murine cytokine responses to mycobacterial antigens by helminth-induced T helper 2 cell responses.
- Screening of a cosmid library of Mycobacterium bovis BCG in Mycobacterium smegmatis for novel T-cell stimulatory antigens.
- Induction of murine T-helper-cell responses to the filarial nematode Brugia malayi.
- Characterization of suppressor function of human alveolar macrophages for T lymphocyte responses to phytohemagglutinin: cellular selectivity, reversibility, and early ...
- Characterization of a 10- to 14-kilodalton protease-sensitive Mycobacterium tuberculosis H37Ra antigen that stimulates human gamma delta T cells.
- Class II major histocompatibility complex molecule expression on murine eosinophils activated in vivo by Brugia malayi.
- CD4+ alpha beta T cell and gamma delta T cell responses to Mycobacterium tuberculosis. Similarities and differences in Ag recognition, cytotoxic effector function, and...
- Alveolar macrophages as accessory cells for human gamma delta T cells activated by Mycobacterium tuberculosis.
- Regulation of production of tumor necrosis factor alpha in monocytes stimulated by the 30-kilodalton antigen of Mycobacterium tuberculosis.
- Human eosinophils as antigen-presenting cells: relative efficiency for superantigen- and antigen-induced CD4+ T-cell proliferation.
- New cause for false-positive results with the cryptococcal antigen test by latex agglutination.
- Successful treatment of multiple brain abscesses with antibiotics alone.
- In vivo and in vitro characterization of murine T-cell clones reactive to Mycobacterium tuberculosis.
- Heterogeneity of helper/inducer T lymphocytes. II. Effects of interleukin 4- and interleukin 2-producing T cell clones on resting B lymphocytes.
- Inhibition of B lymphocyte activation by interferon-gamma.
- Septic cortical thrombophlebitis.
- Heterogeneity of helper/inducer T lymphocytes. IV. Stimulation of resting and activated B cells by Th1 and Th2 clones.
- Patterns of cytokine secretion in murine leishmaniasis: correlation with disease progression or resolution.
- Heterogeneity of helper/inducer T lymphocytes. III. Responses of IL-2- and IL-4-producing (Th1 and Th2) clones to antigens presented by different accessory cells.
- Selective expansion of human gamma delta T cells by monocytes infected with live Mycobacterium tuberculosis.
- Human immune response to Mycobacterium tuberculosis antigens.
- Human Mycobacterium tuberculosis-reactive CD4+ T-cell clones: heterogeneity in antigen recognition, cytokine production, and cytotoxicity for mononuclear phagocytes.
- Role of the mononuclear phagocyte as an antigen-presenting cell for human gamma delta T cells activated by live Mycobacterium tuberculosis.
- A role for CD4+CD25+ T cells in regulation of the immune response during human tuberculosis.
- Neutrophil-mediated mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 mice.
- Human immunity to M. tuberculosis: T cell subsets and antigen processing.
- Early and extended early bactericidal activity of levofloxacin, gatifloxacin and moxifloxacin in pulmonary tuberculosis.
- Sputum Mycobacterium tuberculosis mRNA as a marker of bacteriologic clearance in response to antituberculosis therapy.
- Time to detection of Mycobacterium tuberculosis as an alternative to quantitative cultures.
- Elevated HIV seroprevalence and risk behavior among Ugandan TB suspects: implications for HIV testing and prevention.
- A randomized trial of punctuated antiretroviral therapy in Ugandan HIV-seropositive adults with pulmonary tuberculosis and CD4? T-cell counts of ? 350 cells/?L.
- TLR2 Signaling Depletes IRAK1 and Inhibits Induction of Type I IFN by TLR7/9.
- Rv2468c, a novel Mycobacterium tuberculosis protein that costimulates human CD4+ T cells through VLA-5.
- CD8+ T cells provide an immunologic signature of tuberculosis in young children.
- A novel metabolite of antituberculosis therapy demonstrates host activation of isoniazid and formation of the isoniazid-NAD+ adduct.
- CDC/NIH Workshop. Tuberculosis biomarker and surrogate endpoint research roadmap.
- HIV-specific gag responses in early infancy correlate with clinical outcome and inversely with viral load.
- Effects of antiretroviral therapy on immune function of HIV-infected adults with pulmonary tuberculosis and CD4+ >350 cells/mm3.
- Bacterial conversion of folinic acid is required for antifolate resistance.
- Genetic susceptibility to tuberculosis associated with cathepsin Z haplotype in a Ugandan household contact study.
- Mycobacteria lacking the RD1 region do not induce necrosis in the lungs of mice lacking interferon-gamma.
- Phosphatidylinositol mannoside from Mycobacterium tuberculosis binds alpha5beta1 integrin (VLA-5) on CD4+ T cells and induces adhesion to fibronectin.
- Immune correlates of acute Mycobacterium tuberculosis infection in household contacts in Kampala, Uganda.
- Mycobacterium tuberculosis LprA is a lipoprotein agonist of TLR2 that regulates innate immunity and APC function.
- Secondary attack rate of tuberculosis in urban households in Kampala, Uganda.
- Mycobacterium tuberculosis lipoproteins directly regulate human memory CD4(+) T cell activation via Toll-like receptors 1 and 2.
- Mycobacterium tuberculosis synergizes with ATP to induce release of microvesicles and exosomes containing major histocompatibility complex class II molecules capable o...
- Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2.
- Mycobacterium tuberculosis and TLR2 agonists inhibit induction of type I IFN and class I MHC antigen cross processing by TLR9.
- Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors.
- Tuberculosis treatment in HIV infected Ugandans with CD4 counts>350 cells/mm reduces immune activation with no effect on HIV load or CD4 count.
- Mycobacterium tuberculosis cell wall glycolipids directly inhibit CD4+ T-cell activation by interfering with proximal T-cell-receptor signaling.
- Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis.
- Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa.
- Shortening treatment in adults with noncavitary tuberculosis and 2-month culture conversion.
- TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.
- HIV-1 infection in infants severely impairs the immune response induced by Bacille Calmette-Guérin vaccine.
- Genome scan of M. tuberculosis infection and disease in Ugandans.
Schools
University Of Rochester School Of Medicine and Dentistry
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
Education
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Massachusetts General Hospital -
George Washington University -
University of Rochester School of Medicine and Dentistry
Hospital
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University Hospitals Case Medical Center
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1447279344 |
| Last Name Of The Provider | BOOM |
| First Name Of The Provider | WILLEM |
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