Professor of Urology; Professor of Oncology
Anesthesiology
Dr. William B. Isaacs, MD
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Dr. William B. Isaacs is an expert in the field of Anesthesiology. He attended Loma Linda University School of Medicine. Doctor William B. Isaacs, MD is also published. He has 100 publications published. The lastest publication: "Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases.'
Publications
- Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases.
- Do environmental factors modify the genetic risk of prostate cancer?
- Polymorphisms influencing prostate-specific antigen concentration may bias genome-wide association studies on prostate cancer.
- Leveraging population admixture to characterize the heritability of complex traits.
- A Peripheral Circulating TH1 Cytokine Profile Is Inversely Associated with Prostate Cancer Risk in CLUE II.
- Understanding the Mechanisms of Androgen Deprivation Resistance in Prostate Cancer at the Molecular Level.
- A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
- Association of variants in genes related to the immune response and obesity with BPH in CLUE II.
- Genome-wide Scan of 29,141 African Americans Finds No Evidence of Directional Selection since Admixture.
- Generalizability of established prostate cancer risk variants in men of African ancestry.
- Identification of a novel germline SPOP mutation in a family with hereditary prostate cancer.
- Rb loss is characteristic of prostatic small cell neuroendocrine carcinoma.
- Telomere length as a risk factor for hereditary prostate cancer.
- Association analysis of 9,560 prostate cancer cases from the International Consortium of Prostate Cancer Genetics confirms the role of reported prostate cancer associa...
- The Prevalence of the HOXB13 G84E Prostate Cancer Risk Allele in Men Treated with Radical Prostatectomy.
- Genetic markers associated with early cancer-specific mortality following prostatectomy.
- Genome-wide Association Study Identifies Genetic Determinants of Urine PCA3 Levels in Men.
- Global patterns of prostate cancer incidence, aggressiveness, and mortality in men of african descent.
- Base pair resolution analysis of TMPRSS2-ERG rearrangements in prostate cancer.
- The G84E mutation of HOXB13 is associated with increased risk for prostate cancer: Results from the REDUCE trial.
- Genome-wide Association Study Identifies Loci at ATF7IP and KLK2 Associated with Percentage of Circulating Free PSA.
- DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases.
- HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG).
- Germline mutations in HOXB13 and prostate-cancer risk.
- A Genome-Wide Search for Loci Interacting with Known Prostate Cancer Risk-Associated Genetic Variants.
- A genome-wide survey over the ChIP-on-chip identified androgen receptor binding genomic regions identifies a novel prostate cancer susceptibility locus at 12q13.13.
- Human polymorphisms at long non-coding RNAs (lncRNAs) and association with prostate cancer risk.
- Genetic Variants in the LEPR, CRY1, RNASEL, IL4, and ARVCF Genes Are Prognostic Markers of Prostate Cancer-Specific Mortality.
- PTEN Protein Loss by Immunostaining: Analytic Validation and Prognostic Indicator for a High Risk Surgical Cohort of Prostate Cancer Patients.
- Genome-wide association study identifies new prostate cancer susceptibility loci.
- Increased gene copy number of ERG on chromosome 21 but not TMPRSS2-ERG fusion predicts outcome in prostatic adenocarcinomas.
- Evaluation of PPP2R2A as a prostate cancer susceptibility gene: a comprehensive germline and somatic study.
- Functional annotation of risk loci identified through genome-wide association studies for prostate cancer.
- Association of prostate cancer risk with snps in regions containing androgen receptor binding sites captured by ChIP-On-chip analyses.
- Germ-line sequence variants of PTEN do not have an important role in hereditary and non-hereditary prostate cancer susceptibility.
- Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.
- National Cancer Institute Prostate Cancer Genetics Workshop.
- Genome-wide copy number variations analysis indentifies common genetic variants at 20p13 associated with aggressiveness of prostate cancer.
- Characterizing genetic risk at known prostate cancer susceptibility Loci in african americans.
- High-Throughput Screen Identifies Novel Inhibitors of Cancer Biomarker {alpha}-Methylacyl Coenzyme A Racemase (AMACR/P504S).
- Fine Mapping of a Region of Chromosome 11q13 Reveals Multiple Independent Loci Associated with Risk of Prostate Cancer.
- A snapshot of the expression signature of androgen receptor splicing variants and their distinctive transcriptional activities.
- Inherited genetic markers discovered to date are able to identify a significant number of men at considerably elevated risk for prostate cancer.
- Prostate cancer predisposition loci and risk of metastatic disease and prostate cancer recurrence.
- Prostate cancer-derived angiogenin stimulates the invasion of prostate fibroblasts.
- Polygenic Risk Score Improves Prostate Cancer Risk Prediction: Results from the Stockholm-1 Cohort Study.
- XMRV: a new virus in prostate cancer?
- Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation.
- Immunomodulatory IL-18 binding protein is produced by prostate cancer cells and its levels in urine and serum correlate with tumor status.
- Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements.
- Association of CASP8 D302H polymorphism with reduced risk of aggressive prostate carcinoma.
- Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2.
- Monocyte chemotactic protein-1 (MCP-1/CCL2) is associated with prostatic growth dysregulation and benign prostatic hyperplasia.
- Association of 17 prostate cancer susceptibility loci with prostate cancer risk in Chinese men.
- Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.
- Human prostate-infiltrating CD8+ T lymphocytes are oligoclonal and PD-1+.
- TMPRSS2-ERG gene fusion status in minute (minimal) prostatic adenocarcinoma.
- Macrophage inhibitory cytokine 1: a new prognostic marker in prostate cancer.
- Estimation of absolute risk for prostate cancer using genetic markers and family history.
- Specific detection of prostate cancer cells in urine by multiplex immunofluorescence cytology.
- Single nucleotide polymorphisms and the likelihood of prostate cancer at a given prostate specific antigen level.
- Prostate cancer risk associated loci in African Americans.
- Fine-mapping and family-based association analyses of prostate cancer risk variants at Xp11.
- Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II.
- Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer.
- Established prostate cancer susceptibility variants are not associated with disease outcome.
- Comprehensive mutational analysis and mRNA isoform quantification of TP63 in normal and neoplastic human prostate cells.
- A novel prostate cancer susceptibility locus at 19q13.
- Association of a germ-line copy number variation at 2p24.3 and risk for aggressive prostate cancer.
- Acute inflammatory proteins constitute the organic matrix of prostatic corpora amylacea and calculi in men with prostate cancer.
- Association of reported prostate cancer risk alleles with PSA levels among men without a diagnosis of prostate cancer.
- Genetic and epigenetic inactivation of TNFRSF10C in human prostate cancer.
- Genome-wide expression analysis of recently processed formalin-fixed paraffin embedded human prostate tissues.
- Endoglin (CD105) as a urinary and serum marker of prostate cancer.
- Genetic and epigenetic inactivation of LPL gene in human prostate cancer.
- Genetic variants and family history predict prostate cancer similar to prostate-specific antigen.
- Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer.
- DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneity.
- An evaluation of PCR primer sets used for detection of Propionibacterium acnes in prostate tissue samples.
- Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12.
- GOLPH2 and MYO6: putative prostate cancer markers localized to the Golgi apparatus.
- Cumulative effect of five genetic variants on prostate cancer risk in multiple study populations.
- Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis.
- Family-based samples can play an important role in genetic association studies.
- Cytokine profiling of prostatic fluid from cancerous prostate glands identifies cytokines associated with extent of tumor and inflammation.
- A multigenic approach to evaluating prostate cancer risk in a systematic replication study.
- Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing.
- alpha-Catenin overrides Src-dependent activation of beta-catenin oncogenic signaling.
- Association between sequence variants at 17q12 and 17q24.3 and prostate cancer risk in European and African Americans.
- Chromosome 8q24 risk variants in hereditary and non-hereditary prostate cancer patients.
- Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.
- Cumulative association of five genetic variants with prostate cancer.
- A molecular analysis of prokaryotic and viral DNA sequences in prostate tissue from patients with prostate cancer indicates the presence of multiple and diverse microo...
- Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis.
- Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP.
- Acne and risk of prostate cancer.
- Multiple genomic alterations on 21q22 predict various TMPRSS2/ERG fusion transcripts in human prostate cancers.
- Viral infections and lower urinary tract symptoms in the third national health and nutrition examination survey.
- Association between two unlinked loci at 8q24 and prostate cancer risk among European Americans.
Schools
Loma Linda University
Loma Linda University Med Center
Chldns Hospital
Doctors Specialties
- Anesthesiology
Accepted Insurances
Education
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Loma Linda University -
Loma Linda University School of Medicine
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