Professor of Medicine, Professor of Molecular Biology and Genetics, Joint of Pathology, Johns Hopkins University School of Medicine
Internal Medicine
Dr. William R. Bishai, MD
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Dr. William R. Bishai is an expert in the field of Internal Medicine. He studied medicine at Harvard Medical School. Harvard Medical School is a one of the best medicals schools. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. He over the years received 2 awards: "Elected Member" and "Investigator". William Bishai is also published. He has 99 publications published. The lastest publication: "Erratum to "Efficacy of Adjunctive Tofacitinib Therapy in Mouse Models of Tuberculosis" [EBioMedicine 2 (8), August 2015, 868-873].'
Publications
- Mutation of Rv2887, a marR-Like Gene, Confers Mycobacterium tuberculosis Resistance to an Imidazopyridine-Based Agent.
- Erratum to "Efficacy of Adjunctive Tofacitinib Therapy in Mouse Models of Tuberculosis" [EBioMedicine 2 (8), August 2015, 868-873].
- A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis.
- Targeting the cell wall of Mycobacterium tuberculosis: A molecular modelling investigation of the interaction of imipenem and meropenem with L,D-transpeptidase 2.
- In vivo prediction of tuberculosis-associated cavity formation in rabbits.
- Verapamil Increases the Bactericidal Activity of Bedaquiline Against Mycobacterium tuberculosis in the Mouse Model.
- Crosstalk between Mycobacterium tuberculosis and the host cell.
- Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation.
- Biological Evaluation of Potent Triclosan-Derived Inhibitors of the Enoyl-Acyl Carrier Protein Reductase InhA in Drug-Sensitive and Drug-Resistant Strains of Mycobacte...
- Revisiting Anti-tuberculosis Activity of Pyrazinamide in Mice.
- Non-classical transpeptidases of Mycobacterium tuberculosis alter cell size, morphology, cytosolic matrix, protein localization, virulence and resistance to β-lactams.
- Efflux Inhibition with Verapamil Potentiates Bedaquiline in Mycobacterium tuberculosis.
- Indoleamides are active against drug-resistant Mycobacterium tuberculosis.
- Computer-aided detection and quantification of cavitary tuberculosis from CT scans.
- Novel Adjunctive Therapies for the Treatment of Tuberculosis.
- Adjuvant host-directed therapy with types 3 and 5 but not type 4 phosphodiesterase inhibitors shortens the duration of tuberculosis treatment.
- Assessment of Clofazimine Activity in a Second-Line Regimen for Tuberculosis in Mice.
- Pharmacokinetic and in vivo Efficacy Studies of the Mycobactin Biosynthesis Inhibitor Salicyl-AMS in Mice.
- Acceleration of Tuberculosis Treatment by Adjunctive Therapy with Verapamil as an Efflux Inhibitor.
- Preliminary Structure-Activity Relationships and Biological Evaluation of Novel Antitubercular Indolecarboxamide Derivatives Against Drug-Susceptible and Drug-Resistan...
- Targeting the Cell Wall of Mycobacterium tuberculosis: Structure and Mechanism of L,D-Transpeptidase 2.
- In reply to 'The added effect of thioridazine in the treatment of drug-resistant tuberculosis' Correspondence.
- New drugs for the treatment of tuberculosis: hope and reality.
- Gene Expression of Mycobacterium tuberculosis Putative Transcription Factors whiB1-7 in Redox Environments.
- Adjunctive TNF Inhibition with Standard Treatment Enhances Bacterial Clearance in a Murine Model of Necrotic TB Granulomas.
- Current tuberculosis diagnostic tools & role of urease breath test.
- Isoniazid resistance without a loss of fitness in Mycobacterium tuberculosis.
- Role of Mycobacterium tuberculosis pknD in the pathogenesis of Central Nervous System Tuberculosis.
- Mouse Model of Necrotic Tuberculosis Granulomas Develops Hypoxic Lesions.
- Characterization of clioquinol and analogues as novel inhibitors of methionine aminopeptidases from Mycobacterium tuberculosis.
- Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis.
- Reporter phage and breath tests: emerging phenotypic assays for diagnosing active tuberculosis, antibiotic resistance, and treatment efficacy.
- Strain-dependent CNS dissemination in guinea pigs after Mycobacterium tuberculosis aerosol challenge.
- Alterations in phospholipid catabolism in Mycobacterium tuberculosis lysX mutant.
- In silico children and the glass mouse model: clinical trial simulations to identify and individualize optimal isoniazid doses in children with tuberculosis.
- Essential Metabolites of Mycobacterium tuberculosis and Their Mimics.
- The stringent response is required for full virulence of Mycobacterium tuberculosis in guinea pigs.
- "Depupylation" of prokaryotic ubiquitin-like protein from mycobacterial proteasome substrates.
- Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains.
- Epidemiology and challenges to the elimination of global tuberculosis.
- The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin.
- Methionine aminopeptidases from Mycobacterium tuberculosis as novel antimycobacterial targets.
- Microbiology. Subversion from the sidelines.
- 13[C]-urea breath test as a novel point-of-care biomarker for tuberculosis treatment and diagnosis.
- The impact of mouse passaging of Mycobacterium tuberculosis strains prior to virulence testing in the mouse and guinea pig aerosol models.
- Heightened vulnerability to MDR-TB epidemics after controlling drug-susceptible TB.
- The risk of infections with tumor necrosis factor-alpha inhibitors.
- Noninvasive pulmonary [18F]-2-fluoro-deoxy-D-glucose positron emission tomography correlates with bactericidal activity of tuberculosis drug treatment.
- Biphasic kill curve of isoniazid reveals the presence of drug-tolerant, not drug-resistant, Mycobacterium tuberculosis in the guinea pig.
- Phosphate depletion: a novel trigger for Mycobacterium tuberculosis persistence.
- The two-domain LysX protein of Mycobacterium tuberculosis is required for production of lysinylated phosphatidylglycerol and resistance to cationic antimicrobial pepti...
- Role of the dosR-dosS two-component regulatory system in Mycobacterium tuberculosis virulence in three animal models.
- Extrapulmonary dissemination of Mycobacterium bovis but not Mycobacterium tuberculosis in a bronchoscopic rabbit model of cavitary tuberculosis.
- Bacterial thymidine kinase as a non-invasive imaging reporter for Mycobacterium tuberculosis in live animals.
- Murine model to study the invasion and survival of Mycobacterium tuberculosis in the central nervous system.
- Metronidazole lacks activity against Mycobacterium tuberculosis in an in vivo hypoxic granuloma model of latency.
- Role of stress response sigma factor SigG in Mycobacterium tuberculosis.
- Roles of SigB and SigF in the Mycobacterium tuberculosis sigma factor network.
- In vivo validation of the mutant selection window hypothesis with moxifloxacin in a murine model of tuberculosis.
- Daily dosing of rifapentine cures tuberculosis in three months or less in the murine model.
- Characterization of a novel cell wall-anchored protein with carboxylesterase activity required for virulence in Mycobacterium tuberculosis.
- Accelerated detection of Mycobacterium tuberculosis genes essential for bacterial survival in guinea pigs, compared with mice.
- Mycobacterium tuberculosis SigF regulates genes encoding cell wall-associated proteins and directly regulates the transcriptional regulatory gene phoY1.
- Role of oral extended-spectrum cephems in the treatment of acute exacerbation of chronic bronchitis.
- Characterization of the Mycobacterium tuberculosis sigma factor SigM by assessment of virulence and identification of SigM-dependent genes.
- Deletion of a Mycobacterium tuberculosis proteasomal ATPase homologue gene produces a slow-growing strain that persists in host tissues.
- Mapping essential domains of Mycobacterium smegmatis WhmD: insights into WhiB structure and function.
- Differential gene expression in response to exposure to antimycobacterial agents and other stress conditions among seven Mycobacterium tuberculosis whiB-like genes.
- Combination chemotherapy with the nitroimidazopyran PA-824 and first-line drugs in a murine model of tuberculosis.
- Potent twice-weekly rifapentine-containing regimens in murine tuberculosis.
- Mycobacterium tuberculosis invasion and traversal across an in vitro human blood-brain barrier as a pathogenic mechanism for central nervous system tuberculosis.
- Weekly moxifloxacin and rifapentine is more active than the denver regimen in murine tuberculosis.
- Rifapentine, moxifloxacin, or DNA vaccine improves treatment of latent tuberculosis in a mouse model.
- Emergence of fluoroquinolone resistance in Mycobacterium tuberculosis during continuously dosed moxifloxacin monotherapy in a mouse model.
- Community-acquired meticillin-resistant Staphylococcus aureus: an emerging threat.
- Designer arrays for defined mutant analysis to detect genes essential for survival of Mycobacterium tuberculosis in mouse lungs.
- Evidence that the Streptomyces developmental protein WhiD, a member of the WhiB family, binds a [4Fe-4S] cluster.
- Modeling in vivo pharmacokinetics and pharmacodynamics of moxifloxacin therapy for Mycobacterium tuberculosis infection by using a novel cartridge system.
- Clinical significance of pneumococcal resistance and factors influencing outcomes.
- Moxifloxacin-containing regimens of reduced duration produce a stable cure in murine tuberculosis.
- Dormancy phenotype displayed by extracellular Mycobacterium tuberculosis within artificial granulomas in mice.
- Latent tuberculosis infection.
- Antibiotic resistance in Streptococcus pneumoniae: what does the future hold?
- Attenuation of late-stage disease in mice infected by the Mycobacterium tuberculosis mutant lacking the SigF alternate sigma factor and identification of SigF-dependen...
- Susceptibility to tuberculosis: clues from studies with inbred and outbred New Zealand White rabbits.
- Short report: modulation of Mycobacterium tuberculosis infection by Plasmodium in the murine model.
- Moxifloxacin-containing regimen greatly reduces time to culture conversion in murine tuberculosis.
- From the Infectious Diseases Society of America (IDSA) meeting - important new findings in HIV treatment and pathogenesis, 2003.
- The clinical significance of macrolide-resistant Streptococcus pneumoniae: it's all relative.
- Fluoroquinolone resistance in patients with newly diagnosed tuberculosis.
- Deletion of Mycobacterium tuberculosis sigma factor E results in delayed time to death with bacterial persistence in the lungs of aerosol-infected mice.
- The rapid development of fluoroquinolone resistance in M. tuberculosis.
- Different strains of Mycobacterium tuberculosis cause various spectrums of disease in the rabbit model of tuberculosis.
- Fluoroquinolones, tuberculosis, and resistance.
- A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: application to Mycobacterium tuberculosis.
- Characterization of the role of the divalent metal ion-dependent transcriptional repressor MntR in the virulence of Staphylococcus aureus.
- Isolation of acid-inducible genes of Mycobacterium tuberculosis with the use of recombinase-based in vivo expression technology.
- Issues in the management of bacterial sinusitis.
Schools
Harvard Medical School
Brigham and Women39s Hospital
Doctors Specialties
- Infectious Disease Medicine
- Internal Medicine
Accepted Insurances
Awards
- Elected Member
- Investigator
Education
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Brigham and Women's Hospital -
Harvard Medical School
Hospital
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Johns Hopkins Hospital
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