Professor, Pathology and Laboratory Medicine, Perelman School of Medicine
Pathology
Dr. William W. Schlaepfer, MD
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William Schlaepfer works in the field of Pathology. He studied medicine at Yale University School of Medicine. Yale University School of Medicine is a one of the best medicals schools. Yale University School of Medicine is ranked 7 in research and 57 in primary care medicine Dr. William W. Schlaepfer has written publications. He has 100 publications published with PubMed. The lastest publication is: 'Mutation in neurofilament transgene implicates RNA processing in the pathogenesis of neurodegenerative disease.'
Publications
- Noninflammatory Cerebral Vasculopathy Associated with Recurrent Ischemic Strokes.
- PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility.
- The complex relation between genotype and phenotype in motor neuron disease.
- Role of neurofilament aggregation in motor neuron disease.
- The role of RNA and RNA processing in neurodegeneration.
- 3' untranslated region in a light neurofilament (NF-L) mRNA triggers aggregation of NF-L and mutant superoxide dismutase 1 proteins in neuronal cells.
- Neurofilament RNA causes neurodegeneration with accumulation of ubiquitinated aggregates in cultured motor neurons.
- Direct interaction of focal adhesion kinase with p190RhoGEF.
- Binding of p190RhoGEF to a destabilizing element on the light neurofilament mRNA is competed by BC1 RNA.
- Untranslated element in neurofilament mRNA has neuropathic effect on motor neurons of transgenic mice.
- Arterial dilatation in purulent meningitis. Case report.
- Proceedings: Calcium uptake by axoplasm extruded from giant axons of Loligo.
- Disruption of neurofilament network with aggregation of light neurofilament protein: a common pathway leading to motor neuron degeneration due to Charcot-Marie-Tooth d...
- RNA-binding protein is involved in aggregation of light neurofilament protein and is implicated in the pathogenesis of motor neuron degeneration.
- HoxB2 binds mutant SOD1 and is altered in transgenic model of ALS.
- Cytoplasmic retention sites in p190RhoGEF confer anti-apoptotic activity to an EGFP-tagged protein.
- Identification of a novel interaction of 14-3-3 with p190RhoGEF.
- p190RhoGEF Binds to a destabilizing element in the 3' untranslated region of light neurofilament subunit mRNA and alters the stability of the transcript.
- Similar poly(C)-sensitive RNA-binding complexes regulate the stability of the heavy and light neurofilament mRNAs.
- Mutation in neurofilament transgene implicates RNA processing in the pathogenesis of neurodegenerative disease.
- Characterization of the mouse neurofilament light (NF-L) gene promoter by in vitro transcription.
- Characterization of ribonucleoprotein complexes and their binding sites on the neurofilament light subunit mRNA.
- Stability determinants are localized to the 3'-untranslated region and 3'-coding region of the neurofilament light subunit mRNA using a tetracycline-inducible promoter.
- Transient expression of the neurofilament proteins NF-L and NF-M by Schwann cells is regulated by axonal contact.
- In vitro activation of the mouse mid-sized neurofilament gene by an NF-1-like transcription factor.
- Coordinate induction of the three neurofilament genes by the Brn-3a transcription factor.
- Methylation and expression of neurofilament genes in tissues and in cell lines of the mouse.
- Brain-specific enhancement of the mouse neurofilament heavy gene promoter in vitro.
- Deletion of 3'-untranslated region alters the level of mRNA expression of a neurofilament light subunit transgene.
- Stabilization of neurofilament transcripts during postnatal development.
- Isolation and characterization of neurofilaments from mammalian brain.
- Calcium-mediated breakdown of glial filaments and neurofilaments in rat optic nerve and spinal cord.
- Calcium-dependent degradation of mammalian neurofilaments by soluble tissue factor(s) from rat spinal cord.
- Assessment of immunological properties of neurofilament triplet proteins.
- Monoclonal antibodies recognize individual neurofilament triplet proteins.
- Preparative separation and amino acid composition of neurofilament triplet proteins.
- Induction of neurofilament triplet proteins in PC12 cells by nerve growth factor.
- An immunoperoxidase study of senile cerebral amyloidosis with pathogenetic considerations.
- Characterization of a brain calcium-activated protease that degrades neurofilament proteins.
- An immunohistochemical study of human central and peripheral nervous system tumors, using monoclonal antibodies against neurofilaments and glial filaments.
- Persistence of immunoreactive neurofilament protein breakdown products in transected rat sciatic nerve.
- Monoclonal antibodies to gel-excised glial filament protein and their reactivities with other intermediate filament proteins.
- Kinase activities associated with calcium-activated neutral proteases.
- Multiple forms of Ca-activated protease from rat brain and muscle.
- Calcium-activated neutral protease (CANP) in brain and other tissues.
- Neurofilament breakdown products in degenerating rat and human peripheral nerves.
- The ultrastructural localization of cholinesterase activity in the peripheral nervous system of rats.
- The ultrastructural localization of cholinesterase activity in the sciatic nerve of the rat.
- Acetylcholinesterase activity of motor and sensory nerve fibers in the spinal nerve roots of the rat.
- Ultrastructural and histochemical studies of a primary sensory neuropathy in rats produced by chronic lead intoxication.
- Cadmium-incidence injury in the rat spinal ganglia.
- Sequential study of endothelial changes in acute cadmium intoxication.
- Quantitative and qualitative study of sural nerve biopsies in Krabbe''s disease.
- Experimental alterations of neurofilaments and neurotubules by calcium and other ions.
- Calcium-induced degeneration of axoplasm in isolated segments of rat peripheral nerve.
- Effects of calcium ion concentration on the degeneration of amputated axons in tissue culture.
- Relationship of myelin internode elongation and growth in the rat sural nerve.
- Effects of energy deprivation on Wallerian degeneration in isolated segments of rat peripheral nerve.
- Axonal degeneration in the sural nerves of cancer patients.
- Stabilization of neurofilaments by vincristine sulfate in low ionic strength media.
- Vincristine-induced axonal alterations in rat peripheral nerve.
- The peripheral neuropathy of globoid cell leukodystrophy.
- Cytochemical demonstration of nucleoside phosphatase activity in myelinated nerve fibers of the rat.
- Experimental lead neuropathy: a disease of the supporting cells in the peripheral nervous system.
- Segmental demyelination in the distal peripheral nerves of chronically diabetic Chinese hamsters.
- Effects of nerve constriction on oxygenated excised segments of rat peripheral nerve.
- Circulating autoantibodies to the 200,000-dalton protein of neurofilaments in the serum of healthy individuals.
- The structure, biochemical properties, and immunogenicity of neurofilament peripheral regions are determined by phosphorylation state.
- Mechanisms underlying the neuronal response to ischemic injury. Calcium-activated proteolysis of neurofilaments.
- The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family.
- Neurofilaments: structure, metabolism and implications in disease.
- Studies of neurofilaments that accumulate in proximal axons of rats intoxicated with beta,beta'-iminodipropionitrile (IDPN).
- Brain MR: pathologic correlation with gross and histopathology. 2. Hyperintense white-matter foci in the elderly.
- Brain MR: pathologic correlation with gross and histopathology. 1. Lacunar infarction and Virchow-Robin spaces.
- mRNA levels of all three neurofilament proteins decline following nerve transection.
- Expression of neurofilament proteins in the hypertrophic granule cells of Lhermitte-Duclos disease: an explanation for the mass effect and the myelination of parallel ...
- Two-stage expression of neurofilament polypeptides during rat neurogenesis with early establishment of adult phosphorylation patterns.
- Monoclonal antibodies distinguish several differentially phosphorylated states of the two largest rat neurofilament subunits (NF-H and NF-M) and demonstrate their exis...
- Phosphorylation of neurofilament proteins and chromatolysis following transection of rat sciatic nerve.
- Structural similarities and differences between neurofilament proteins from five different species as revealed using monoclonal antibodies.
- Clustering of phosphorylated amino acid residues in neurofilament proteins as revealed by 31P NMR.
- 2,5-Hexanedione neuropathy is associated with the covalent crosslinking of neurofilament proteins.
- Calcium-activated proteolysis of intermediate filaments.
- Characterization of calcium-activated neutral protease (CANP)-associated protein kinase from bovine brain and its phosphorylation of neurofilaments.
- An immunoblot study of neurofilament degradation in situ and during calcium-activated proteolysis.
- Activation of calpain I and calpain II: a comparative study using terbium as a fluorescent probe for calcium-binding sites.
- Calcium-activated neutral proteases (calpains) are carbohydrate binding proteins.
- Domain structure of neurofilament subunits as revealed by monoclonal antibodies.
- Axonal dependency of the postnatal upregulation in neurofilament expression.
- Neurofilament proteins are distributed in a diminishing proximodistal gradient along rat sciatic nerve.
- Simultaneous up-regulation of neurofilament proteins during the postnatal development of the rat nervous system.
- Two-stage autolysis of the catalytic subunit initiates activation of calpain I.
- Negative regulatory regions are present upstream in the three mouse neurofilament genes.
- Actinomycin prevents the destabilization of neurofilament mRNA in primary sensory neurons.
- Proximo-distal gradient of endoneurial collagen in rat peripheral nerves.
- Calcium-dependent alterations of neurofilament proteins of rat peripheral nerve.
- Neurofilament proteins of rat peripheral nerve and spinal cord.
- Chemical and structural changes of neurofilaments in transected rat sciatic nerve.
- Protein composition of axons and myelin from rat and human peripheral nerves.
Schools
Yale University
Grace New Haven Community Hospital
Doctors Specialties
- Neuropathology
- Pathology
Accepted Insurances
- Personal Choice PPO
- Regional Pref Network EPO
- Regional Pref Network HMO
- Regional Pref Network HMO+
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- Blue Card PPO
- Cigna
- Commercial Insurance Company
- CoreSource
- Emblem Health
- Geisinger Health Plan
- HealthPartners
- Community Blue PPO
- Keystone Health Plan East HMO
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- Medicare MCR
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- QualCare HMO
- QualCare PPO
- Oxford Liberty
- United Healthcare
Education
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Yale-New Haven Hospital -
Yale University School of Medicine
Hospital
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Hospital of the University of Pennsylvania -
Pennsylvania Hospital -
Penn Presbyterian Medical Center
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