Physician
Infectious Disease
James W. Larrick
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James Larrick works in the field of Infectious Disease. James W. Larrick is also a published doctor. He has 101 paper published. The most recent paper is: Bcl-2-mediated resistance to apoptosis is associated with glutathione-induced inhibition of AP24 activation of nuclear DNA fragmentation.
Publications
- Telomerase Redux: ready for prime time?
- Systemic factors mediate reversible age-associated brain dysfunction.
- Paradoxical effects of antioxidants on cancer.
- Partial Reversal of Skeletal Muscle Aging by Restoration of Normal NAD(+) Levels.
- Sleep facilitates clearance of metabolites from the brain: Glymphatic function in aging and neurodegenerative diseases.
- Trade-offs between Anti-aging Dietary Supplementation and Exercise.
- Rejuvenation of aging hearts.
- Willem 'pim' stemmer 1957-2013.
- Dietary modification of the microbiome affects risk for cardiovascular disease.
- Affinity maturation and fine functional mapping of an antibody fragment against a novel neutralizing epitope on human vascular endothelial growth factor.
- Rejuvenation of adult stem cells: is age-associated dysfunction epigenetic?
- The DNA methylome as a biomarker for epigenetic instability and human aging.
- FGF21 is a promising dietary restriction mimetic.
- Ectopic expression of telomerase safely increases health span and life span.
- Dissecting Mammalian target of rapamycin to promote longevity.
- Overcoming the aging systemic milieu to restore neural stem cell function.
- Reversing age-related decline in working memory.
- Rapamycin as an antiaging therapeutic?: targeting Mammalian target of rapamycin to treat hutchinson-gilford progeria and neurodegenerative diseases.
- Medical implications of basic science: protein homeostasis as a clinical target for increased longevity?
- Master switch of mitochondrial biogenesis: a clinical target for health span enhancement?
- Applied Healthspan engineering.
- Targeted in vivo extracellular matrix formation promotes neovascularization in a rodent model of myocardial infarction.
- Antibody targeting of stem cells to infarcted myocardium.
- CC-1065 analogues bearing different DNA-binding subunits: synthesis, antitumor activity, and preliminary toxicity study.
- Synthesis and cytotoxicity of a biotinylated CC-1065 analogue.
- Synthesis and preliminary cytotoxicity study of a cephalosporin-CC-1065 analogue prodrug.
- Recombinant antibodies.
- Human neutrophil granule cationic protein CAP37 is a specific macrophage chemotaxin that shares homology with inflammatory proteinases.
- In vitro immunization of human B lymphocytes. MAPPing of lymphokine specific mRNA and the effect of recombinant factors.
- Complementary DNA sequence of rabbit CAP18--a unique lipopolysaccharide binding protein.
- Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes.
- Primer design for the cloning of immunoglobulin heavy-chain leader-variable regions from mouse hybridoma cells using the PCR.
- Tumor necrosis factor induces activation of mitochondrial succinate dehydrogenase.
- Soluble suppressive molecule released by human T lymphocytes induced by heat-inactivated allostimulator cells in the presence of cyclosporine.
- Human monoclonal antibodies specific for capsular polysaccharides of Klebsiella recognize clusters of multiple serotypes.
- The methyl xanthine hypothesis: does tea consumption by Tibetan natives blunt the effects of high altitude?
- Rabbit CAP18 derived peptides inhibit gram negative and gram positive bacteria.
- Endotoxin-binding synthetic peptides with endotoxin-neutralizing, antibacterial and anticoagulant activities.
- Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein.
- Smoking and neurogenerative diseases.
- Doxorubicin and DNA minor groove-binding oligopeptide conjugates as anticancer agents.
- Purification of a 24-kD protease from apoptotic tumor cells that activates DNA fragmentation.
- Inhibition of apoptosis as a mechanism of tumor promotion.
- Variable region sequences of a protective human monoclonal antibody specific for the Haemophilus influenzae type b capsular polysaccharide.
- Antimicrobial activity of rabbit CAP18-derived peptides.
- Characterization of a rabbit cationic protein (CAP18) with lipopolysaccharide-inhibitory activity.
- A novel granulocyte-derived peptide with lipopolysaccharide-neutralizing activity.
- Role of protein phosphorylation in TNF-induced apoptosis: phosphatase inhibitors synergize with TNF to activate DNA fragmentation in normal as well as TNF-resistant U9...
- Nicotine inhibition of apoptosis suggests a role in tumor promotion.
- Regulation of neutrophil interleukin 8 gene expression and protein secretion by LPS, TNF-alpha, and IL-1 beta.
- Allotypic dependency of the specificity and avidity of human monoclonal IgM rheumatoid factors derived from rheumatoid synovial cells.
- Structure and functions of endotoxin-binding peptides derived from CAP18.
- Isolation and characterization of a chimpanzee monoclonal antibody to the G glycoprotein of human respiratory syncytial virus.
- Biochemical pathways of apoptosis: nicotinamide adenine dinucleotide-deficient cells are resistant to tumor necrosis factor or ultraviolet light activation of the 24-k...
- Identification of functional and structural amino-acid residues by parsimonious mutagenesis.
- Structural, functional analysis and localization of the human CAP18 gene.
- A derivative of cationic antimicrobial protein attenuates lung injury by suppressing cell adhesion.
- Antimicrobial action of rabbit leukocyte CAP18(106-137).
- Ligation of MHC class I induces apoptosis in human pre-B cell lines, in promyelocytic cell lines and in CD40-stimulated mature B cells.
- Testing the power of belief.
- Calmodulin-dependent protein kinase II mediates signal transduction in apoptosis.
- Activation of CPP32-like proteases is not sufficient to trigger apoptosis: inhibition of apoptosis by agents that suppress activation of AP24, but not CPP32-like activ...
- Meeting report from the ''Therapeutic Antibody Technology 95'' meeting--not just ''another recombinant antibody meeting''.
- Anti-microbial activity of human CAP18 peptides.
- Green fluorescent protein: untapped potential in immunotechnology.
- Role of circulating endotoxin and interleukin-6 in the ACTH and corticosterone response to intraperitoneal LPS.
- Therapeutic antibody technology 97.
- Autoinducer of virulence as a target for vaccine and therapy against Staphylococcus aureus.
- Production of antibodies in transgenic plants.
- Evaluation of antimicrobial and lipopolysaccharide-neutralizing effects of a synthetic CAP18 fragment against Pseudomonas aeruginosa in a mouse model.
- Bcl-2-mediated resistance to apoptosis is associated with glutathione-induced inhibition of AP24 activation of nuclear DNA fragmentation.
- Molecular mechanisms of interaction of rabbit CAP18 with outer membranes of gram-negative bacteria.
- Synthesis and preliminary biological evaluations of CC-1065 analogues: effects of different linkers and terminal amides on biological activity.
- Antibody engineering at the millennium.
- Mechanisms of action of rabbit CAP18 on monolayers and liposomes made from endotoxins or phospholipids.
- Interaction of CAP18-derived peptides with membranes made from endotoxins or phospholipids.
- Producing proteins in transgenic plants and animals.
- Production of secretory IgA antibodies in plants.
- Hybrid IgA2/IgG1 antibodies with tailor-made effector functions.
- Co-migration and internalization of transferrin and its receptor on K562 cells.
- Acquired iron-deficiency anemia caused by an antibody against the transferrin receptor.
- Production of human monoclonal antibody in mouse ascites.
- Characterization of human hybridomas secreting antibody to tetanus toxoid.
- Protective effect of snake venom antibodies in sera of previous snake bite victims.
- Digital and palmar dermatoglyphic patterns among natives of extreme northwest Nepal.
- Does hyperimmunoglobulinemia-E protect tropical populations from allergic disease?
- Studies of endemic cretinism in Papua New Guinea: digital and palmar dermatoglyphic patterns.
- Gm and Inv (Km) studies of Melanesian people on the Huon Peninsula in Northeast Papua New Guinea: polymorphism for a Gm1,5,10,11,13,14,17,21,26 Haplotype.
- Snake venom antibodies in Ecuadorian Indians.
- Should mild hypertension be treated with drugs?
- Infectious disease patterns in the Waorani, an isolated Amerindian population.
- Characterization of a human macrophage-like cell line stimulated in vitro: a model of macrophage functions.
- Hyperimmunoglobulinemia E in the Waorani, an isolated Amerindian population.
- Antibody engineering by parsimonious mutagenesis.
- Variable region sequence modulates periplasmic export of a single-chain Fv antibody fragment in Escherichia coli.
- The solution structure of the active domain of CAP18--a lipopolysaccharide binding protein from rabbit leukocytes.
- PCR MIMICS: competitive DNA fragments for use as internal standards in quantitative PCR.
- Transferrin receptors on leukaemic cells.
- Transferrin receptors on human B and T lymphoblastoid cell lines.
- Thymus Maintenance and Regeneration by Specific Molecular Factors.
Schools
Duke University
Doctors Specialties
- Infectious Disease Medicine
- Medical Oncology
- Oncology
- Infectious Disease
Accepted Insurances
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