Physician
Pathology
Jon S. Keller, PA-C
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Jon S. Keller, PA-C practices Pathology. He graduated from University of Michigan Medical School. Keller is also a published MD. He has 101 publication published. The most recent publication is: D3: a gene induced during myeloid cell differentiation of Linlo c-Kit+ Sca-1(+) progenitor cells. He accepts Medicare payments and is registered with Medicare.gov.
Publications
- Contrasting mechanisms of the myeloprotective effects of interleukin-1 against ionizing radiation and cytotoxic 5-fluorouracil.
- Transforming growth factor beta and interleukin-1: a paradigm for opposing regulation of haemopoiesis.
- Transcriptome analysis of mouse stem cells and early embryos.
- Transforming growth factor-beta: a bidirectional regulator of hematopoietic cell growth.
- Recombinant transforming growth factor beta 1 and beta 2 protect mice from acutely lethal doses of 5-fluorouracil and doxorubicin.
- Prevention of acute chemotherapy-induced death in mice by recombinant human interleukin 1: protection from hematological and nonhematological toxicities.
- Growth inhibition of a human lymphoma cell line: induction of a transforming growth factor-beta-mediated autocrine negative loop by phorbol myristate acetate.
- Effects of growth hormone and prolactin on hematopoiesis.
- Epstein-Barr virus transformed B lymphocytes produce interleukin-5.
- Transforming growth factor beta inhibits the action of stem cell factor on mouse and human hematopoietic progenitors.
- Interleukins 2 and 3 regulate the in vitro proliferation of two distinguishable populations of 20-alpha-hydroxysteroid dehydrogenase-positive cells.
- Stimulation of granulopoiesis by transforming growth factor beta: synergy with granulocyte/macrophage-colony-stimulating factor.
- Retroviral v-myc infection of primary fetal liver cells: transformation of monocytes in vitro.
- Transforming growth factor beta: possible roles in the regulation of normal and leukemic hematopoietic cell growth.
- Transforming growth factor beta is a potent inhibitor of interleukin 1 (IL-1) receptor expression: proposed mechanism of inhibition of IL-1 action.
- In vivo and in vitro effects of TGF-beta 1 on normal and neoplastic haemopoiesis.
- Mobilization of long-term reconstituting hematopoietic stem cells in mice by recombinant human interleukin 7.
- Local clonal analysis of the hematopoietic system shows that multiple small short-living clones maintain life-long hematopoiesis in reconstituted mice.
- Role of transforming growth factor-beta 1 in regulation of hematopoiesis.
- Antineoplastic dolastatins: potent inhibitors of hematopoietic progenitor cells.
- Role of fibroblast growth factors and their receptors in mouse primordial germ cell growth.
- Direct synergistic effects of IL-4 and IL-11 on proliferation of primitive hematopoietic progenitor cells.
- Transforming growth factor-beta regulates c-kit message stability and cell-surface protein expression in hematopoietic progenitors.
- Increased granulopoiesis after sequential administration of transforming growth factor-beta 1 and granulocyte-macrophage colony-stimulating factor.
- Severe congenital neutropenia: abnormal growth and differentiation of myeloid progenitors to granulocyte colony-stimulating factor (G-CSF) but normal response to G-CSF...
- Transforming growth factor-beta 1 enhances the suppression of human hematopoiesis by tumor necrosis factor-alpha or recombinant interferon-alpha.
- TGF-beta is a bidirectional modulator of cytokine receptor expression on murine bone marrow cells. Differential effects of TGF-beta 1 and TGF-beta 3.
- Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells.
- Tumor necrosis factor alpha directly and indirectly regulates hematopoietic progenitor cell proliferation: role of colony-stimulating factor receptor modulation.
- Administration of recombinant human interleukin-7 to mice induces the exportation of myeloid progenitor cells from the bone marrow to peripheral sites.
- Inhibition of early murine hemopoietic progenitor cell proliferation after in vivo locoregional administration of transforming growth factor-beta 1.
- Bidirectional effects of transforming growth factor beta (TGF-beta) on colony-stimulating factor-induced human myelopoiesis in vitro: differential effects of distinct ...
- Transforming growth factor beta selectively inhibits normal and leukemic human bone marrow cell growth in vitro.
- Two forms of transforming growth factor-beta are equally potent selective growth inhibitors of early murine hematopoiesis.
- Transforming growth factor beta directly regulates primitive murine hematopoietic cell proliferation.
- Retroviral transduction of IL-7Ralpha into IL-7Ralpha-/- bone marrow progenitors: correction of lymphoid deficiency and induction of neutrophilia.
- Hematopoietic growth factors and glucocorticoids synergize to mimic the effects of IL-1 on granulocyte differentiation and IL-1 receptor induction on bone marrow cells...
- Hematopoiesis and thymic apoptosis are not affected by the loss of Cdk2.
- Detection of growth factor receptor RNA in individual hematopoietic cells by in situ RT-PCR; comparison with RT-PCR.
- Raf-1 protein is required for growth factor-induced proliferation of hematopoietic cells.
- Redirected infection of directly biotinylated recombinant adenovirus vectors through cell surface receptors and antigens.
- In vivo effect of interleukin-1 alpha on hematopoiesis: role of colony-stimulating factor receptor modulation.
- The growth response of Lin-Thy-1+ hematopoietic progenitors to cytokines is determined by the balance between synergy of multiple stimulators and negative cooperation ...
- Identification of an interleukin-3-regulated aldoketo reductase gene in myeloid cells which may function in autocrine regulation of myelopoiesis.
- Stem cell factor, the JAK-STAT pathway and signal transduction.
- Unique pathway of IL-3-driven hemopoietic differentiation.
- Quantitative and cell-cycle differences in progenitor cells mobilized by recombinant human interleukin-7 and recombinant human granulocyte colony-stimulating factor.
- Hematopoietic growth factors upregulate the p65 type II interleukin-1 receptor on bone marrow progenitor cells in vitro.
- In vivo interleukin-1 (IL-1) administration indirectly promotes type II IL-1 receptor expression on hematopoietic bone marrow cells: novel mechanism for the hematopoie...
- Transforming growth factor beta 1 selectively regulates early murine hematopoietic progenitors and inhibits the growth of IL-3-dependent myeloid leukemia cell lines.
- Interleukin-2-activated natural killer cells can support hematopoiesis in vitro and promote marrow engraftment in vivo.
- Hepatocyte growth factor is a synergistic factor for the growth of hematopoietic progenitor cells.
- Transforming growth factor-beta trans-modulates the expression of colony stimulating factor receptors on murine hematopoietic progenitor cell lines.
- Stem cell factor induces phosphorylation of a 200 kDa protein which associates with c-kit.
- The effect of c-raf antisense oligonucleotides on growth factor-induced proliferation of hematopoietic cells.
- Functional characterization of a novel hematopoietic stem cell and its place in the c-Kit maturation pathway in bone marrow cell development.
- Targeted gene transfer to human hematopoietic progenitor cell lines through the c-kit receptor.
- Introduction of v-abl oncogene induces monocytic differentiation of an IL-3-dependent myeloid progenitor cell line.
- Direct evidence for an intracellular role for IFN-gamma. Microinjection of human IFN-gamma induces Ia expression on murine macrophages.
- Id1 immortalizes hematopoietic progenitors in vitro and promotes a myeloproliferative disease in vivo.
- Engraftment of SCID mice by human bone marrow hematopoietic cells cultured in vitro: an in vivo model for human gene transfer.
- Distinct and direct synergistic effects of IL-1 and IL-6 on proliferation and differentiation of primitive murine hematopoietic progenitor cells in vitro.
- C/EBPepsilon is a myeloid-specific activator of cytokine, chemokine, and macrophage-colony-stimulating factor receptor genes.
- Raf-1 protein is required for growth factor-induced proliferation of primitive hematopoietic progenitors stimulated with synergistic combinations of cytokines.
- JAK2 is constitutively associated with c-Kit and is phosphorylated in response to stem cell factor.
- Direct synergistic effects of leukemia inhibitory factor on hematopoietic progenitor cell growth: comparison with other hematopoietins that use the gp130 receptor subu...
- Gene transfer of multidrug resistance into a factor-dependent human hematopoietic progenitor cell line: in vivo model for genetically transferred chemoprotection.
- D3: a gene induced during myeloid cell differentiation of Linlo c-Kit+ Sca-1(+) progenitor cells.
- Engraftment of ex vivo expanded and cycling human cord blood hematopoietic progenitor cells in SCID mice.
- JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor.
- Interleukin-1 (IL-1) directly and indirectly promotes hematopoietic cell growth through type I IL-1 receptor.
- Distinct and overlapping direct effects of macrophage inflammatory protein-1 alpha and transforming growth factor beta on hematopoietic progenitor/stem cell growth.
- Steel factor (c-kit ligand) promotes the survival of hematopoietic stem/progenitor cells in the absence of cell division.
- Induction of colony-stimulating factor receptor expression on hematopoietic progenitor cells: proposed mechanism for growth factor synergism.
- C/EBPalpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo.
- The interferon-inducible p200 family of proteins: a perspective on their roles in cell cycle regulation and differentiation.
- Ablation of the transcriptional regulator Id1 enhances energy expenditure, increases insulin sensitivity, and protects against age and diet induced insulin resistance,...
- RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis.
- Repression of Id2 expression by Gfi-1 is required for B-cell and myeloid development.
- Cell-nonautonomous function of Id1 in the hematopoietic progenitor cell niche.
- The lamin B receptor under transcriptional control of C/EBPepsilon is required for morphological but not functional maturation of neutrophils.
- Id2 intrinsically regulates lymphoid and erythroid development via interaction with different target proteins.
- DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development.
- The role of p202 in regulating hematopoietic cell proliferation and differentiation.
- Gene expression analysis of hematopoietic progenitor cells identifies Dlg7 as a potential stem cell gene.
- IL-7 induces myelopoiesis and erythropoiesis.
- Role of the intracellular domain of IL-7 receptor in T cell development.
- Novel lymphotoxin alpha (LTalpha) knockout mice with unperturbed tumor necrosis factor expression: reassessing LTalpha biological functions.
- Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation.
- C/EBPalpha determines hematopoietic cell fate in multipotential progenitor cells by inhibiting erythroid differentiation and inducing myeloid differentiation.
- p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation.
- Inhibitory effects of tumor necrosis factor on hematopoiesis seen in vitro are translated to increased numbers of both committed and multipotent progenitors in TNF-def...
- IL-3 induces inhibitor of DNA-binding protein-1 in hemopoietic progenitor cells and promotes myeloid cell development.
- Inhibition of growth by p205: a nuclear protein and putative tumor suppressor expressed during myeloid cell differentiation.
- Distinct regions of the interleukin-7 receptor regulate different Bcl2 family members.
- Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival.
- JAK2 contributes to the intrinsic capacity of primary hematopoietic cells to respond to stem cell factor.
- Identification of in vitro growth conditions for c-Kit-negative hematopoietic stem cells.
- Bcl11a is essential for normal lymphoid development.
- In vivo retroviral gene transfer by direct intrafemoral injection results in correction of the SCID phenotype in Jak3 knock-out animals.
Doctors Specialties
- Physician Assistant (PA)
- Pathology
Accepted Insurances
- Choice Plus POS II
- Blue Card PPO
- MultiPlan PPO
- PHCS Network PPO
- Qualchoice PPO
Education
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University of Vermont - Fletcher Allen Health Care -
University of Michigan Medical School
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1538181078 |
| Last Name Of The Provider | KELLER |
| First Name Of The Provider | JON |
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