Professor, Molecular and Cellular Physiology, Stanford University Medical Center

Internal Medicine

Brian K. Kobilka, MD practices Internal Medicine. He attended Yale University School of Medicine. Yale University School of Medicine is one of the top medical schools in the US. Yale University School of Medicine is ranked 7/57 in Research/PrimaryCare. He received 2 awards: "Elected Member" and "Investigator Alumnus". Brian K. Kobilka, MD is also published. He has 100 publications published. The lastest publication: "High-density grids for efficient data collection from multiple crystals.'

Publications

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• High-density grids for efficient data collection from multiple crystals.
• Allosteric regulation of G protein-coupled receptor activity by phospholipids.
• Development and Characterization of Pepducins as Gs-biased Allosteric Agonists.
• Modified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis.
• Nanoscale high-content analysis using compositional heterogeneities of single proteoliposomes.
• Visualization of arrestin recruitment by a G-protein-coupled receptor.
• Muscarinic acetylcholine receptors: novel opportunities for drug development.
• Muscarinic acetylcholine receptor X-ray structures: potential implications for drug development.
• Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.
• The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin.
• Applications of molecular replacement to G protein-coupled receptors.
• Activation and allosteric modulation of a muscarinic acetylcholine receptor.
• Muscarinic Receptors as Model Targets and Antitargets for Structure-Based Ligand Discovery.
• Novel Insights into M3 Muscarinic Acetylcholine Receptor Physiology and Structure.
• Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody.
• The Structural Basis of G-Protein-Coupled Receptor Signaling (Nobel Lecture).
• Structure of active ?-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.
• Identification of GPCR-Interacting Cytosolic Proteins Using HDL Particles and Mass Spectrometry-Based Proteomic Approach.
• The Dynamic Process of ?(2)-Adrenergic Receptor Activation.
• A new era of GPCR structural and chemical biology.
• Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM.
• The PDZ binding motif of the beta 1 adrenergic receptor modulates receptor trafficking and signaling in cardiac myocytes.
• Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes.
• Skeletal muscle hypertrophy and anti-atrophy effects of clenbuterol are mediated by the beta2-adrenergic receptor.
• Isoflurane and nociception: spinal alpha2A adrenoceptors mediate antinociception while supraspinal alpha1 adrenoceptors mediate pronociception.
• Allosteric modulation of beta2-adrenergic receptor by Zn(2+).
• The ectodomain of the luteinizing hormone receptor interacts with exoloop 2 to constrain the transmembrane region: studies using chimeric human and fly receptors.
• Use of fluorescence spectroscopy to study conformational changes in the beta 2-adrenoceptor.
• Structure and function of an irreversible agonist-β(2) adrenoceptor complex.
• Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.
• Tandem facial amphiphiles for membrane protein stabilization.
• Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins.
• Energy landscapes as a tool to integrate GPCR structure, dynamics, and function.
• International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular...
• A device for separated and reversible co-culture of cardiomyocytes.
• Regulation of G-protein coupled receptor traffic by an evolutionary conserved hydrophobic signal.
• Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor.
• Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model lipid bilayer.
• Understanding the ligand-receptor-G protein ternary complex for GPCR drug discovery.
• The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex.
• The structure and function of G-protein-coupled receptors.
• Structure-based discovery of beta2-adrenergic receptor ligands.
• Structural insights into G-protein-coupled receptor activation.
• New G-protein-coupled receptor crystal structures: insights and limitations.
• Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4.
• High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.
• GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function.
• A monoclonal antibody for G protein-coupled receptor crystallography.
• Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
• Activation of G protein-coupled receptors.
• Conformational complexity of G-protein-coupled receptors.
• N-ethylmaleimide-sensitive factor regulates beta2 adrenoceptor trafficking and signaling in cardiomyocytes.
• A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein.
• Structure and conformational changes in the C-terminal domain of the beta2-adrenoceptor: insights from fluorescence resonance energy transfer studies.
• Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes.
• Counting low-copy number proteins in a single cell.
• G protein coupled receptor structure and activation.
• Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR.
• PDZ-domain arrays for identifying components of GPCR signaling complexes.
• Functional selectivity and classical concepts of quantitative pharmacology.
• Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor.
• Differential targeting and function of alpha2A and alpha2C adrenergic receptor subtypes in cultured sympathetic neurons.
• Phospholipid biotinylation of polydimethylsiloxane (PDMS) for protein immobilization.
• Effect of targeted deletions of beta1- and beta2-adrenergic-receptor subtypes on heart rate variability.
• Differential cardioprotective/cardiotoxic effects mediated by beta-adrenergic receptor subtypes.
• Using synthetic lipids to stabilize purified beta2 adrenoceptor in detergent micelles.
• Mass spectrometric analysis of agonist effects on posttranslational modifications of the beta-2 adrenoceptor in mammalian cells.
• Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists.
• A fluorescent probe designed for studying protein conformational change.
• Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes.
• Toward understanding GPCR dimers.
• Agonist binding: a multistep process.
• Protecting the myocardium: a role for the beta2 adrenergic receptor in the heart.
• Plasmon-waveguide resonance studies of ligand binding to the human beta 2-adrenergic receptor.
• The third intracellular loop and the carboxyl terminus of beta2-adrenergic receptor confer spontaneous activity of the receptor.
• Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states.
• The PDZ-binding motif of the beta2-adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes.
• Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox.
• Myocyte adrenoceptor signaling pathways.
• Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II.
• Efficient adenylyl cyclase activation by a beta2-adrenoceptor-G(i)alpha2 fusion protein.
• Identification of an allosteric binding site for Zn2+ on the beta2 adrenergic receptor.
• Abnormal cardiac function associated with sympathetic nervous system hyperactivity in mice.
• Functional immobilization of a ligand-activated G-protein-coupled receptor.
• Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine.
• Analysis of biomolecular interactions using a miniaturized surface plasmon resonance sensor.
• Heterozygous alpha 2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists.
• betaAR signaling required for diet-induced thermogenesis and obesity resistance.
• Structure and dynamics of the M3 muscarinic acetylcholine receptor.
• Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist.
• Conformational changes in the G protein Gs induced by the β2 adrenergic receptor.
• Conformational dynamics of single G protein-coupled receptors in solution.
• Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex.
• Nanobody stabilization of G protein-coupled receptor conformational states.
• Crystal structure of the β2 adrenergic receptor-Gs protein complex.
• Structural insights into adrenergic receptor function and pharmacology.
• Molecular and cellular biology of adrenergic receptors.
• Adrenergic Receptors From Molecular Structure to in vivo function.
• Behavioral and neurochemical characterization of alpha(2A)-adrenergic receptor knockout mice.

Schools

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• Yale University

• Barnes Hospital

• Duke University

Doctors Specialties

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• Internal Medicine

Accepted Insurances

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Awards

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• Elected Member
• Investigator Alumnus

Education

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• Duke University Hospital
• Washington University - Barnes-Jewish Hospital
• Yale University School of Medicine

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