Professor, Medicine, University of Connecticut SOM
Endocrinology
Dr. Carol C. Pilbeam, MD
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Carol Pilbeam is an expert in the field of Endocrinology. She researched medicine at Yale University School of Medicine. Yale University School of Medicine is one of the top medical schools in the US. Yale University School of Medicine is ranked 7 in research and 57 in primary care medicine Carol C. Pilbeam is also a published physician. She has 89 publication published. The most recent publication is: Low dose estrogen and calcium have an additive effect on bone resorption in older women.
Publications
- Increased expression of L-selectin (CD62L) in high-grade urothelial carcinoma: A potential marker for metastatic disease.
- Prostaglandin E2 acts via bone marrow macrophages to block PTH-stimulated osteoblast differentiation in vitro.
- Lawrence G. Raisz November 13, 1925-August 25, 2010.
- Basal bone phenotype and increased anabolic responses to intermittent parathyroid hormone in healthy male COX-2 knockout mice.
- Prostaglandins in bone: bad cop, good cop?
- Parathyroid hormone induction of cyclooxygenase-2 in murine osteoblasts: role of the calcium-calcineurin-NFAT pathway.
- Bone morphogenetic protein 2 enhances PGE(2)-stimulated osteoclast formation in murine bone marrow cultures.
- Neuropeptide Y is expressed by osteocytes and can inhibit osteoblastic activity.
- Effects of global or targeted deletion of the EP4 receptor on the response of osteoblasts to prostaglandin in vitro and on bone histomorphometry in aged mice.
- Effects of prostaglandin E2 on bone in mice in vivo.
- Role of the cyclooxygenase pathway in chemotherapy-induced oral mucositis: a pilot study.
- Regulation of the prostaglandin pathway during development of invasive bladder cancer in mice.
- Anabolic effects of PTH in cyclooxygenase-2 knockout osteoblasts in vitro.
- Role of the prostaglandin pathway and the use of NSAIDs in genitourinary malignancies.
- Measurement of muscle disease by quantitative second-harmonic generation imaging.
- Effect of deletion of the prostaglandin EP2 receptor on the anabolic response to prostaglandin E2 and a selective EP2 receptor agonist.
- Effects of prostaglandin E2 and lipopolysaccharide on osteoclastogenesis in RAW 264.7 cells.
- Null mutation for macrophage migration inhibitory factor (MIF) is associated with less aggressive bladder cancer in mice.
- Cyclooxygenase-2 gene disruption promotes proliferation of murine calvarial osteoblasts in vitro.
- Strontium ranelate promotes osteoblastic differentiation and mineralization of murine bone marrow stromal cells: involvement of prostaglandins.
- Null mutation in macrophage migration inhibitory factor prevents muscle cell loss and fibrosis in partial bladder outlet obstruction.
- Fluid flow induces Rankl expression in primary murine calvarial osteoblasts.
- Overexpression of COX-2 in human osteosarcoma cells decreases proliferation and increases apoptosis.
- Role of Cbfa1/Runx2 in the fluid shear stress induction of COX-2 in osteoblasts.
- Effect of deletion of the prostaglandin EP4 receptor on stimulation of calcium release from cultured mouse calvariae: impaired responsiveness in heterozygotes.
- Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfa1 binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo. 2...
- Do cyclooxygenase-2 knockout mice have primary hyperparathyroidism?
- Biphasic effect of prostaglandin E2 on osteoclast formation in spleen cell cultures: role of the EP2 receptor.
- Differential regulation of platelet-derived growth factor stimulated migration and proliferation in osteoblastic cells.
- Extracellular calcium induces COX-2 in osteoblasts via a PKA pathway.
- Stimulation of cAMP production and cyclooxygenase-2 by prostaglandin E(2) and selective prostaglandin receptor agonists in murine osteoblastic cells.
- The effect of deletion of cyclooxygenase-2, prostaglandin receptor EP2, or EP4 in bone marrow cells on osteoclasts induced by mouse mammary cancer cell lines.
- Extracellular calcium is a potent inducer of cyclo-oxygenase-2 in murine osteoblasts through an ERK signaling pathway.
- Role of cyclooxygenase-2 in bone resorption.
- Fluid flow induces COX-2 expression in MC3T3-E1 osteoblasts via a PKA signaling pathway.
- Cell-to-Cell adhesion via intercellular adhesion molecule-1 and leukocyte function-associated antigen-1 pathway is involved in 1alpha,25(OH)2D3, PTH and IL-1alpha-indu...
- Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfal binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo.
- Effects of prostaglandin E2 on gene expression in primary osteoblastic cells from prostaglandin receptor knockout mice.
- Prostaglandin receptor EP2 mediates PGE2 stimulated hypercalcemia in mice in vivo.
- Regulation of fibroblast growth factor 2 and fibroblast growth factor receptors by transforming growth factor beta in human osteoblastic MG-63 cells.
- Fluid flow induction of cyclo-oxygenase 2 gene expression in osteoblasts is dependent on an extracellular signal-regulated kinase signaling pathway.
- Effects of selective prostaglandin EP4 receptor antagonist on osteoclast formation and bone resorption in vitro.
- Involvement of CCAAT enhancer binding protein transcription factors in the regulation of prostaglandin G/H synthase 2 expression by interleukin-1 in osteoblastic MC3T3...
- Knockout of the murine prostaglandin EP2 receptor impairs osteoclastogenesis in vitro.
- Identification of multiple cis-acting elements mediating the induction of prostaglandin G/H synthase-2 by phorbol ester in murine osteoblastic cells.
- Prostaglandin G/H synthase-2 is required for maximal formation of osteoclast-like cells in culture.
- Low dose estrogen and calcium have an additive effect on bone resorption in older women.
- Regulation of prostaglandin G/H synthase-2 expression by interleukin-1 in human osteoblast-like cells.
- Mice lacking the type I interleukin-1 receptor do not lose bone mass after ovariectomy.
- Transforming growth factor-beta1 regulation of prostaglandin G/H synthase-2 expression in osteoblastic MC3T3-E1 cells.
- Molecular cloning and expression of a rat prostaglandin E2 receptor of the EP2 subtype.
- Parathyroid hormone increases prostaglandin G/H synthase-2 transcription by a cyclic adenosine 3',5'-monophosphate-mediated pathway in murine osteoblastic MC3T3-E1 cells.
- Differential effects of nonsteroidal anti-inflammatory drugs on constitutive and inducible prostaglandin G/H synthase in cultured bone cells.
- Transcriptional induction of cyclooxygenase-2 in osteoblasts is involved in interleukin-6-induced osteoclast formation.
- Pulsating fluid flow stimulates prostaglandin release and inducible prostaglandin G/H synthase mRNA expression in primary mouse bone cells.
- Regulation of inducible prostaglandin G/H synthase by interleukin-1, transforming growth factors-alpha and -beta, and prostaglandins in bone cells.
- Lack of evidence for an increase in interleukin-6 expression in adult murine bone, bone marrow, and marrow stromal cell cultures after ovariectomy.
- Parathyroid hormone induces prostaglandin G/H synthase-2 expression by a cyclic adenosine 3',5'-monophosphate-mediated pathway in the murine osteoblastic cell line MC3...
- Interleukin-4 inhibits prostaglandin G/H synthase-2 and cytosolic phospholipase A2 induction in neonatal mouse parietal bone cultures.
- Intact insulin-like growth factor binding protein-5 (IGFBP-5) associates with bone matrix and the soluble fragments of IGFBP-5 accumulated in culture medium of neonata...
- The effect of a short course of calcium and vitamin D on bone turnover in older women.
- Expression and regulation of prostaglandin F receptor mRNA in rodent osteoblastic cells.
- The short term effects of tamoxifen on bone turnover in older women.
- Transcriptional induction of prostaglandin G/H synthase-2 by basic fibroblast growth factor.
- Ovariectomy enhances and estrogen replacement inhibits the activity of bone marrow factors that stimulate prostaglandin production in cultured mouse calvariae.
- Fracture incidence in postmenopausal women with primary hyperparathyroidism.
- The role of prostaglandins in the regulation of bone metabolism.
- Autoregulation of inducible prostaglandin G/H synthase in osteoblastic cells by prostaglandins.
- Treatment of osteoporosis.
- The anabolic effects of progesterone on fetal rat calvaria in tissue culture.
- Regulation of the two prostaglandin G/H synthases by parathyroid hormone, interleukin-1, cortisol, and prostaglandin E2 in cultured neonatal mouse calvariae.
- Anabolic effects of 3,3',5-triiodothyronine and triiodothyroacetic acid in cultured neonatal mouse parietal bones.
- The short-term effects of conjugated estrogen on bone turnover in older women.
- Measurement of interleukin-1 stimulated constitutive prostaglandin G/H synthase (cyclooxygenase) mRNA levels in osteoblastic MC3T3-E1 cells using competitive reverse t...
- Stimulation of prostaglandin E2 production by interleukin-1 alpha and transforming growth factor alpha in osteoblastic MC3T3-E1 cells.
- Comparison of the effects of 3,5,3'-triiodothyroacetic acid and triiodothyronine on bone resorption in cultured fetal rat long bones and neonatal mouse calvariae.
- Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic MC3T3-E1 cells.
- Comparison of the effects of various lengths of synthetic human parathyroid hormone-related peptide (hPTHrP) of malignancy on bone resorption and formation in organ cu...
- Prostaglandins: mechanisms of action and regulation of production in bone.
- Production of both 92- and 72-kDa gelatinases by bone cells.
- Effect of 1,25-dihydroxyvitamin D3 on prostaglandin E2 production in cultured mouse parietal bones.
- Mechanism of regulation of prostaglandin production by parathyroid hormone, interleukin-1, and cortisol in cultured mouse parietal bones.
- Effects of androgens on parathyroid hormone and interleukin-1-stimulated prostaglandin production in cultured neonatal mouse calvariae.
- An evaluation of the relative contributions of exposure to sunlight and of diet to the circulating concentrations of 25-hydroxyvitamin D in an elderly nursing home pop...
- Inhibition by 17 beta-estradiol of PTH stimulated resorption and prostaglandin production in cultured neonatal mouse calvariae.
- Cyclooxygenase-2 Suppresses the Anabolic Response to PTH Infusion in Mice.
- Serum Amyloid A3 Secreted by Preosteoclasts Inhibits Parathyroid Hormone-stimulated cAMP Signaling in Murine Osteoblasts.
- Prostaglandin-mediated inhibition of PTH-stimulated β-catenin signaling in osteoblasts by bone marrow macrophages.
Schools
Yale University
Waterbury Hospital Health Center
Harvard Med School
Doctors Specialties
- Geriatric Medicine
- Endocrinology
Accepted Insurances
Education
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Beth Israel Deaconess Medical Center -
Yale University School of Medicine
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