Professor, Medicine, University of Connecticut SOM
Endocrinology
Dr. Marja M. Hurley, MD
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Marja M. Hurley practices Endocrinology. She studied medicine at University of Connecticut School of Medicine. University of Connecticut School of Medicine has a rank of 60 in research and a 49 in primary care Dr. Marja M. Hurley has written publications. She has 64 publications published with PubMed. The lastest publication is: 'Prostaglandins regulate the expression of fibroblast growth factor-2 in bone.'
Publications
- Accelerated fracture healing in transgenic mice overexpressing an anabolic isoform of fibroblast growth factor 2.
- Effects of low dose FGF-2 and BMP-2 on healing of calvarial defects in old mice.
- Knockout of Nuclear High Molecular Weight FGF2 Isoforms in Mice Modulates Bone and Phosphate Homeostasis.
- Fibroblast Growth Factor-2 Isoform (Low Molecular Weight/18 kDa) Overexpression in Preosteoblast Cells Promotes Bone Regeneration in Critical Size Calvarial Defects in...
- Fibroblast Growth Factor-2 and Bone Morphogenetic Protein-2 Have a Synergistic Stimulatory Effect on Bone Formation in Cell Cultures From Elderly Mouse and Human Bone.
- Fibroblast Growth Factor-2, Bone Homeostasis and Fracture Repair.
- Role of fibroblast growth factor 2 and Wnt signaling in anabolic effects of parathyroid hormone on bone formation.
- Nuclear FGF2 isoforms inhibit bone marrow stromal cell mineralization through FGF23/FGFR/MAPK in vitro.
- FGF2 stimulation of osteoblast differentiation and bone formation is mediated by modulation of the WNT pathway.
- The impaired bone anabolic effect of PTH in the absence of endogenous FGF2 is partially due to reduced ATF4 expression.
- Signaling pathways implicated in PGF2alpha effects on Fgf2+/+ and Fgf2-/- osteoblasts.
- Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells.
- Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO.
- Fibroblast growth factor 2 positively regulates expression of activating transcription factor 4 in osteoblasts.
- Endogenous FGF-2 is critically important in PTH anabolic effects on bone.
- Exported 18-kDa isoform of fibroblast growth factor-2 is a critical determinant of bone mass in mice.
- Prostaglandin F2alpha involves heparan sulphate sugar chains and FGFRs to modulate osteoblast growth and differentiation.
- Reduced expression and function of bone morphogenetic protein-2 in bones of Fgf2 null mice.
- Anti-apoptotic Bcl-2 enhancing requires FGF-2/FGF receptor 1 binding in mouse osteoblasts.
- Benzyl butyl phthalate influences actin distribution and cell proliferation in rat Py1a osteoblasts.
- University of Connecticut HPPI pipeline.
- PGF2alpha increases FGF-2 and FGFR2 trafficking in Py1a rat osteoblasts via clathrin independent and importin beta dependent pathway.
- Stat1 controls postnatal bone formation by regulating fibroblast growth factor signaling in osteoblasts.
- Impaired osteoclast formation in bone marrow cultures of Fgf2 null mice in response to parathyroid hormone.
- Prostaglandins differently regulate FGF-2 and FGF receptor expression and induce nuclear translocation in osteoblasts via MAPK kinase.
- Over-expression of fibroblast growth factor-2 causes defective bone mineralization and osteopenia in transgenic mice.
- Effect of overexpressing fibroblast growth factor 2 protein isoforms in osteoblastic ROS 17/2.8 cells.
- In vivo and in vitro comparison of the effects of FGF-2 null and haplo-insufficiency on bone formation in mice.
- Interleukin-1 regulates FGF-2 mRNA and localization of FGF-2 protein in human osteoblasts.
- FGF-2 increases colony formation, PTH receptor, and IGF-1 mRNA in mouse marrow stromal cells.
- Basic fibroblast growth factor induces osteoclast formation in murine bone marrow cultures.
- Impaired bone anabolic response to parathyroid hormone in Fgf2-/- and Fgf2+/- mice.
- Basic fibroblast growth factor inhibits type I collagen gene expression in osteoblastic MC3T3-E1 cells.
- Expression and regulation of basic fibroblast growth factor mRNA levels in mouse osteoblastic MC3T3-E1 cells.
- Intact insulin-like growth factor binding protein-5 (IGFBP-5) associates with bone matrix and the soluble fragments of IGFBP-5 accumulated in culture medium of neonata...
- Regulation of fibroblast growth factor 2 and fibroblast growth factor receptors by transforming growth factor beta in human osteoblastic MG-63 cells.
- Phthalate esters influence FGF-2 translocation in Py1a rat osteoblasts.
- Effects of phthalate esters on actin cytoskeleton of Py1a rat osteoblasts.
- Parathyroid hormone regulates the expression of fibroblast growth factor-2 mRNA and fibroblast growth factor receptor mRNA in osteoblastic cells.
- Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation.
- Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation.
- Transcriptional induction of prostaglandin G/H synthase-2 by basic fibroblast growth factor.
- Regulation of NFIL-6 and IL-6 expression by basic fibroblast growth factor in osteoblasts.
- Stage specific inhibition of osteoblast lineage differentiation by FGF2 and noggin.
- The interaction of heparin and basic fibroblast growth factor on collagen synthesis in 21-day fetal rat calvariae.
- Fibroblast growth factor-2 stimulates the proliferation of mesenchyme-derived progenitor cells from aging mouse and human bone.
- Transcriptional regulation of the collagenase gene by basic fibroblast growth factor in osteoblastic MC3T3-E1 cells.
- Prostaglandins regulate the expression of fibroblast growth factor-2 in bone.
- PNA lectin as marker of Py1a cell cycle.
- FGF and FGFR signaling in chondrodysplasias and craniosynostosis.
- Effects of ethanol and acetaldehyde on collagen synthesis, prostaglandin release and resorption of fetal rat bone in organ culture.
- Effect of heparin on bone formation in cultured fetal rat calvaria.
- Interactive effects of basic fibroblast growth factor and heparin on bone in 21-day fetal rat calvariae.
- Effects of transforming growth factor alpha and interleukin-1 on DNA synthesis, collagen synthesis, procollagen mRNA levels, and prostaglandin E2 production in culture...
- Signal transduction by basic fibroblast growth factor in rat osteoblastic Py1a cells.
- Basic fibroblast growth factor regulates IGF-I binding proteins in the clonal osteoblastic cell line MC3T3-E1.
- Comparison of the effects of auranofin, gold sodium thiomalate, and penicillamine on resorption of cultured fetal rat long bones.
- Comparison of commercially available parathyroid hormone immunoassays in the differential diagnosis of hypercalcemia: a reanalysis.
- Changes in serum fibroblast growth factor 2 in patients with glucocorticoid-induced osteoporosis treated with human parathyroid hormone (1-34).
- Structural determinants of the capacity of heparin to inhibit collagen synthesis in 21-day fetal rat calvariae.
- Changes in ethanol concentration during incubation in multiwell tissue culture trays.
- Important roles of PI3Kgamma in osteoclastogenesis and bone homeostasis.
- Stimulatory effect of a phorbol ester on expression of insulin-like growth factor (IGF) binding protein-2 and level of IGF-I receptors in mouse osteoblastic MC3T3-E1 c...
Schools
Univ Of Ct Sch Of Med
John Dempsey Hospital
John Dempsey Hospital University Conn
University Conn Health Center
Doctors Specialties
- Internal Medicine
- Endocrinology
Accepted Insurances
Education
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University of Connecticut -
University of Connecticut School of Medicine
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