Assistant Professor, Pathology, University of Washington School of Medicine
Pathology
Dr. Christopher D. Keene, MD
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Christopher Keene practices Pathology. He researched medicine at University of Minnesota Medical School. University of Minnesota Medical School has a rank of 40 in research and a 10 in primary care Christopher Keene has written publications. He has 50 publications published with PubMed. The lastest paper is: 'Precision Medicine: Clarity for the Complexity of Dementia.' He accepts Medicare payments and is registered with Medicare.gov.
Publications
- Precision Medicine: Clarity for the Complexity of Dementia.
- Cerebral cortical Aβ42 and PHF-Ä in 325 consecutive brain autopsies stratified by diagnosis, location, and APOE.
- APOE genotype-dependent modulation of astrocyte chemokine CCL3 production.
- Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expre...
- Prostaglandin E2 Receptor Subtype 2 Regulation of Scavenger Receptor CD36 Modulates Microglial Aβ42 Phagocytosis.
- Orbital extension of anterior uveal melanoma after Baerveldt tube shunt implantation.
- Flow cytometry analysis of synaptosomes from post-mortem human brain reveals changes specific to Lewy body and Alzheimer's disease.
- Hemorrhagic collision metastasis in a cerebral arteriovenous malformation.
- Wild-type bone marrow transplant partially reverses neuroinflammation in progranulin-deficient mice.
- Orbital Metastasis of Undifferentiated/Anaplastic Thyroid Carcinoma.
- Retinal Neovascularization and Endogenous Fungal Endophthalmitis in Intravenous Drug Users.
- Therapeutic implications of the prostaglandin pathway in Alzheimer's disease.
- Orbital Neoplasms in Adults: Clinical, Radiologic, and Pathologic Review.
- Novel mutations in ataxia telangiectasia and AOA2 associated with prolonged survival.
- Epigenetic signature and enhancer activity of the human APOE gene.
- A Case of Nodular Fasciitis Causing Compressive Optic Neuropathy.
- APOE3, but Not APOE4, Bone Marrow Transplantation Mitigates Behavioral and Pathological Changes in a Mouse Model of Alzheimer Disease.
- Perivascular, but not parenchymal, cerebral engraftment of donor cells after non-myeloablative bone marrow transplantation.
- A diagnostic dilemma: infectious versus noninfectious multifocal choroiditis with panuveitis.
- Ablation of the microglial protein DOCK2 reduces amyloid burden in a mouse model of Alzheimer's disease.
- Gravin Is a Transitory Effector of Polo-like Kinase 1 during Cell Division.
- Eicosanoid receptor subtype-mediated opposing regulation of TLR-stimulated expression of astrocyte glial-derived neurotrophic factor.
- Antagonism of Neuronal Prostaglandin E(2) Receptor Subtype 1 Mitigates Amyloid β Neurotoxicity In Vitro.
- Metabolic changes in quinolinic acid-lesioned rat striatum detected non-invasively by in vivo (1)H NMR spectroscopy.
- A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease.
- Age-dependent changes in the calcium sensitivity of striatal mitochondria in mouse models of Huntington''s Disease.
- Selective dendritic degeneration of medium spiny neurons in dementia with Lewy bodies.
- Neural transplantation in Huntington disease: long-term grafts in two patients.
- Neurochemical changes in Huntington R6/2 mouse striatum detected by in vivo 1H NMR spectroscopy.
- Thymidine analogs are transferred from prelabeled donor to host cells in the central nervous system after transplantation: a word of caution.
- Neural induction of adult bone marrow and umbilical cord stem cells.
- Severely impaired learning and altered neuronal morphology in mice lacking NMDA receptors in medium spiny neurons.
- Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer''s disease.
- Role of cerebrospinal fluid and plasma biomarkers in the diagnosis of neurodegenerative disorders and mild cognitive impairment.
- Apolipoprotein E isoform-dependent microglia migration.
- Suppressed microglial E prostanoid receptor 1 signaling selectively reduces tumor necrosis factor alpha and interleukin 6 secretion from toll-like receptor 3 activation.
- Comparison of analytical mathematical approaches for identifying key nuclear magnetic resonance spectroscopy biomarkers in the diagnosis and assessment of clinical cha...
- Suppressed accumulation of cerebral amyloid {beta} peptides in aged transgenic Alzheimer's disease mice by transplantation with wild-type or prostaglandin E2 receptor ...
- Parahippocampal corpora amylacea: case report.
- Protection of hippocampal neurogenesis from toll-like receptor 4-dependent innate immune activation by ablation of prostaglandin E2 receptor subtype EP1 or EP2.
- A patient with Huntington''s disease and long-surviving fetal neural transplants that developed mass lesions.
- Proteomics of human neurodegenerative diseases.
- Therapeutic targets in prostaglandin E2 signaling for neurologic disease.
- Biomarkers for Alzheimer''s disease.
- Highly resolved in vivo 1H NMR spectroscopy of the mouse brain at 9.4 T.
- Neural differentiation and incorporation of bone marrow-derived multipotent adult progenitor cells after single cell transplantation into blastocyst stage mouse embryos.
- Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease.
- Pluripotency of mesenchymal stem cells derived from adult marrow.
- Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats.
Doctors Specialties
- Neuropathology
- Pathology
Accepted Insurances
Education
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University of Washington -
University of Minnesota Medical School
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1104928712 |
| Last Name Of The Provider | KEENE |
| First Name Of The Provider | CHRISTOPHER |
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