Physician
Pathology
Dr. Thomas J. Montine, MD
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Thomas Montine practices Pathology. Dr. Thomas J. Montine is also published. He has 100 publications published. The lastest publication: "Rarity of the Alzheimer Disease-Protective APP A673T Variant in the United States.'
Publications
- Rarity of the Alzheimer Disease-Protective APP A673T Variant in the United States.
- Effects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease: A Genome-Wide Association Study.
- Aggregates of small nuclear ribonucleic acids (snRNAs) in Alzheimer's disease.
- Digestion products of the PH20 hyaluronidase inhibit remyelination.
- Age-dependent changes in the cerebrospinal fluid proteome by slow off-rate modified aptamer array.
- National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach.
- Novel Antibody Capture Assay for Paraffin-Embedded Tissue Detects Wide-Ranging Amyloid Beta and Paired Helical Filament-Tau Accumulation in Cognitively Normal Older Ad...
- High-intensity physical activity modulates diet effects on cerebrospinal amyloid-β levels in normal aging and mild cognitive impairment.
- Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment: A Pilot Clinical Trial.
- Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer''s disease.
- White matter lesions defined by diffusion tensor imaging in older adults.
- Ecology of the aging human brain.
- Role of cerebrospinal fluid and plasma biomarkers in the diagnosis of neurodegenerative disorders and mild cognitive impairment.
- The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers.
- Mitochondrial therapeutics in Alzheimer's disease and Parkinson's disease.
- Treatment with a ?-Ketoaldehyde Scavenger Prevents Working Memory Deficits in hApoE4 Mice.
- Apolipoprotein E isoform-dependent microglia migration.
- Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment.
- Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
- Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic gu...
- Suppressed microglial E prostanoid receptor 1 signaling selectively reduces tumor necrosis factor alpha and interleukin 6 secretion from toll-like receptor 3 activation.
- Complement 3 and factor h in human cerebrospinal fluid in Parkinson's disease, Alzheimer's disease, and multiple-system atrophy.
- Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype.
- Increased cerebrospinal fluid F2-isoprostanes are associated with aging and latent Alzheimer's disease as identified by biomarkers.
- Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression.
- Prevalence estimates for latent neurodegenerative disease.
- Measurement of isoprostanes as markers of oxidative stress.
- Severely impaired learning and altered neuronal morphology in mice lacking NMDA receptors in medium spiny neurons.
- Diabetes and insulin in regulation of brain cholesterol metabolism.
- Attenuated progression of diet-induced steatohepatitis in glutathione-deficient mice.
- CSF Aβ(42) and tau in Parkinson's disease with cognitive impairment.
- Morphometric analysis in neurodegenerative disorders.
- Aberrant detergent-insoluble excitatory amino acid transporter 2 accumulates in Alzheimer disease.
- Suppressed accumulation of cerebral amyloid {beta} peptides in aged transgenic Alzheimer's disease mice by transplantation with wild-type or prostaglandin E2 receptor ...
- The prostaglandin E2 E-prostanoid 4 receptor exerts anti-inflammatory effects in brain innate immunity.
- Quantitative proteomic analysis of oligodendrogliomas with and without 1p/19q deletion.
- APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure.
- The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration.
- Elevated ratio of urinary metabolites of thromboxane and prostacyclin is associated with adverse cardiovascular events in ADAPT.
- Glycoproteomics in neurodegenerative diseases.
- Late-life dementias: does this unyielding global challenge require a broader view?
- Blood pressure and brain injury in older adults: findings from a community-based autopsy study.
- Parkinson-dementia complex and development of a new stable isotope dilution assay for BMAA detection in tissue.
- DOCK2 is a microglial specific regulator of central nervous system innate immunity found in normal and Alzheimer's disease brain.
- Depletion of B lymphocytes from cerebral perivascular spaces by rituximab.
- Identification of glutathione S-transferase pi as a protein involved in Parkinson disease progression.
- Associations between microinfarcts and other macroscopic vascular findings on neuropathologic examination in 2 databases.
- Protection of hippocampal neurogenesis from toll-like receptor 4-dependent innate immune activation by ablation of prostaglandin E2 receptor subtype EP1 or EP2.
- Different patterns of cerebral injury in dementia with or without diabetes.
- Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking.
- Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects.
- Proteomics of human neurodegenerative diseases.
- The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis.
- Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models.
- Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease.
- Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the omega-3 polyunsaturated fatty acid docosahexaenoic acid.
- F2-dihomo-isoprostanes arise from free radical attack on adrenic acid.
- Translational gene mapping of cognitive decline.
- CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases.
- Multiplex immunoassay analysis of cytokines in idiopathic inflammatory myopathy.
- Pathological correlates of dementia in a longitudinal, population-based sample of aging.
- F(2)-isoprostanes as biomarkers of late-onset Alzheimer's disease.
- Quantitative proteomics identifies surfactant-resistant alpha-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or prog...
- Proteomic discovery of CSF biomarkers for Alzheimer's disease.
- Washington statewide pathology surveillance for prion disease.
- Response to Harri Hemilä, Ph.D., M.D. - "Conclusions about intervention effects should not be based on surrogate end points.
- Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice.
- Effects of chemical chaperones on oxidative stress and detergent-insoluble species formation following conditional expression of amyloid precursor protein carboxy-term...
- LR11/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease.
- Selectively increased oxidative modifications mapped to detergent-insoluble forms of Abeta and beta-III tubulin in Alzheimer's disease.
- Liquid chromatography with tandem mass spectrometry-based proteomic discovery in aging and Alzheimer's disease.
- Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK.
- Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype.
- Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation.
- Characterization of proteome of human cerebrospinal fluid.
- Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease.
- Proteomic determination of widespread detergent-insolubility including Abeta but not tau early in the pathogenesis of Alzheimer's disease.
- Microglial EP2 is critical to neurotoxicity from activated cerebral innate immunity.
- Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults.
- Lack of beta-methylamino-l-alanine in brain from controls, AD, or Chamorros with PDC.
- Selective vulnerability of preterm white matter to oxidative damage defined by F2-isoprostanes.
- Fatty acid oxidation in the pathogenesis of Alzheimer's disease.
- Proteomic analysis of neurofibrillary tangles in Alzheimer disease identifies GAPDH as a detergent-insoluble paired helical filament tau binding protein.
- Microglia lacking E Prostanoid Receptor subtype 2 have enhanced Abeta phagocytosis yet lack Abeta-activated neurotoxicity.
- Quantitative proteomic analysis of age-related changes in human cerebrospinal fluid.
- F2-isoprostanes in Alzheimer and other neurodegenerative diseases.
- {alpha}-Tocopherol disappearance is faster in cigarette smokers and is inversely related to their ascorbic acid status.
- Analysis of alpha-synuclein-associated proteins by quantitative proteomics.
- HIV associated neurodegeneration requires p53 in neurons and microglia.
- Oxidized low-density lipoprotein is present in astrocytes surrounding cerebral infarcts and stimulates astrocyte interleukin-6 secretion.
- Quantification of F-ring isoprostane-like compounds (F4-neuroprostanes) derived from docosahexaenoic acid in vivo in humans by a stable isotope dilution mass spectrome...
- Combined deficiency of vitamins E and C causes paralysis and death in guinea pigs.
- Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer's disease and correlation with APOE.
- Mercapturate metabolism of 4-hydroxy-2-nonenal in rat and human cerebrum.
- Catalysis of catechol oxidation by metal-dithiocarbamate complexes in pesticides.
- Carbonyl toxicology and Alzheimer's disease.
- Dopamine thioethers: formation in brain and neurotoxicity.
- Formation of highly reactive A-ring and J-ring isoprostane-like compounds (A4/J4-neuroprostanes) in vivo from docosahexaenoic acid.
- Lipid peroxidation in aging brain and Alzheimer's disease.
Schools
McGill University Faculty Of Medicine
Duke University
Vanderbilt University
Doctors Specialties
- Neuropathology
- Pathology
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