Associate Professor of Pathology, Massachusetts General Hospital
Pathology
Dr. Dennis C. Sgroi, MD
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Dennis C. Sgroi practices Pathology. He attended University of Connecticut School of Medicine. University of Connecticut School of Medicine is ranked 60/49 in Research/PrimaryCare. Doctor Dennis C. Sgroi, MD has written publications. He has 64 publications published with PubMed. The lastest publication is: 'Nodes-and-connections RNAi knockdown screening: identification of a signaling molecule network involved in fulvestrant action and breast cancer prognosis.'
Publications
- Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor.
- Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility.
- Eight-year update of a prospective study of wide excision alone for small low- or intermediate-grade ductal carcinoma in situ (DCIS).
- Prediction of late distant recurrence in patients with oestrogen-receptor-positive breast cancer: a prospective comparison of the breast-cancer index (BCI) assay, 21-g...
- Breast cancer index identifies early-stage estrogen receptor-positive breast cancer patients at risk for early- and late-distant recurrence.
- Prediction of Late Disease Recurrence and Extended Adjuvant Letrozole Benefit by the HOXB13/IL17BR Biomarker.
- Planning cancer control in Latin America and the Caribbean.
- Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition.
- Sequence analysis of mutations and translocations across breast cancer subtypes.
- Integrated proteomic, transcriptomic, and biological network analysis of breast carcinoma reveals molecular features of tumorigenesis and clinical relapse.
- NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology.
- Breast Cancer Special Feature: The HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathway.
- PIK3R1 (p85-alpha/p85{alpha}) is Somatically Mutated at High Frequency in Primary Endometrial Cancer.
- A unique spectrum of somatic PIK3CA (p110alpha) mutations within primary endometrial carcinomas.
- Induction of stable drug resistance in human breast cancer cells using a combinatorial zinc finger transcription factor library.
- In situ proteomic analysis of human breast cancer epithelial cells using laser capture microdissection: annotation by protein set enrichment analysis and gene ontology.
- A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
- Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer.
- Preinvasive breast cancer.
- Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes.
- Prevalence and functional analysis of sequence variants in the ATR checkpoint mediator Claspin.
- Case records of the Massachusetts General Hospital. Case 25-2009. A 36-year-old woman with hormone-receptor-positive breast cancer.
- Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies.
- Breast cancer SRC activity: bad to the bone.
- Laser capture microdissection of human pancreatic beta-cells and RNA preparation for gene expression profiling.
- Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistance.
- Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification.
- Analysis of the MammaPrint breast cancer assay in a predominantly postmenopausal cohort.
- Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection.
- Identification and rational redesign of peptide ligands to CRIP1, a novel biomarker for cancers.
- Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts.
- The prognostic biomarkers HOXB13, IL17BR, and CHDH are regulated by estrogen in breast cancer.
- HOXB13 promotes ovarian cancer progression.
- A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors.
- The Spemann organizer gene, Goosecoid, promotes tumor metastasis.
- The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer.
- Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon.
- Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas.
- Frequent met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis.
- A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen.
- Prospective study of wide excision alone for ductal carcinoma in situ of the breast.
- Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752.
- Novel role for PDEF in epithelial cell migration and invasion.
- Response of some head and neck cancers to epidermal growth factor receptor tyrosine kinase inhibitors may be linked to mutation of ERBB2 rather than EGFR.
- Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials.
- Case records of the Massachusetts General Hospital. Case 24-2005. A 58-year-old woman with early-stage estrogen-receptor-positive breast cancer.
- G1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression.
- Mapping molecular networks using proteomics: a vision for patient-tailored combination therapy.
- Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion.
- RE: A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen.
- A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen.
- Proteomic analysis of ductal carcinoma of the breast using laser capture microdissection, LC-MS, and 16O/18O isotopic labeling.
- Sclerosing lesions of the breast.
- Laser capture microdissection and advanced molecular analysis of human breast cancer.
- Gene expression profiles of human breast cancer progression.
- Proteomics of human breast ductal carcinoma in situ.
- Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation.
- In situ gene expression analysis of cancer using laser capture microdissection, microarrays and real time quantitative PCR.
- Selective loss of heterozygosity in multiple breast cancers from a carrier of mutations in both BRCA1 and BRCA2.
- Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia.
- Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia.
- Nodes-and-connections RNAi knockdown screening: identification of a signaling molecule network involved in fulvestrant action and breast cancer prognosis.
- Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays.
Schools
Univ Of Ct Sch Of Med
Mass General Hospital Ma
Doctors Specialties
- Anatomic Pathology
- Pathology
Accepted Insurances
Education
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Massachusetts General Hospital -
University of Connecticut School of Medicine
Hospital
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Massachusetts General Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1023008331 |
| Last Name Of The Provider | SGROI |
| First Name Of The Provider | DENNIS |
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