Professor of Biological Chemistry and Molecular Pharmacology, Boston Children's Hospital
Hematology
Dr. George Q. Daley, MD
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George Daley practices Hematology. He went to medical school at Harvard Medical School. Harvard Medical School is a top medical university. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. He over the years received 3 awards: "Elected Member", "Whos Who in Medicine and Healthcare" and "Investigator". George Q. Daley is also a published doctor. He has 101 paper published. The most recent paper is: Sex-specific regulation of weight and puberty by the Lin28/let-7 axis.
Publications
- Sex-specific regulation of weight and puberty by the Lin28/let-7 axis.
- De novo generation of HSCs from somatic and pluripotent stem cell sources.
- A prudent path forward for genomic engineering and germline gene modification.
- Metabolic switches linked to pluripotency and embryonic stem cell differentiation.
- The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancy.
- Deconstructing transcriptional heterogeneity in pluripotent stem cells.
- A comparison of non-integrating reprogramming methods.
- The Epithelial-Mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming.
- Effect of Developmental Stage of HSC and Recipient on Transplant Outcomes.
- Alternative Splicing of MBD2 Supports Self-Renewal in Human Pluripotent Stem Cells.
- Lin28 sustains early renal progenitors and induces Wilms tumor.
- Distinct and Combinatorial Functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in Mouse Embryonic Stem Cell Identity.
- A chemical logic for reprogramming to pluripotency.
- Lin28 enhances tissue repair by reprogramming cellular metabolism.
- Hematopoietic defects and iPSC disease modeling: Lessons learned.
- Stem cells: Reprogramming in situ.
- Optimization of scarless human stem cell genome editing.
- Induced pluripotent stem cells with a mitochondrial DNA deletion.
- Stem cell metabolism in tissue development and aging.
- Fetal Deficiency of Lin28 Programs Life-Long Aberrations in Growth and Glucose Metabolism.
- Deciphering the rules of ceRNA networks.
- Pluripotent Stem Cell Models of Shwachman-Diamond Syndrome Reveal a Common Mechanism for Pancreatic and Hematopoietic Dysfunction.
- Lin28: primal regulator of growth and metabolism in stem cells.
- Lin28a Regulates Germ Cell Pool Size and Fertility.
- Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition.
- A blueprint for engineering cell fate: current technologies to reprogram cell identity.
- Cellular alchemy and the golden age of reprogramming.
- The transcriptional landscape of hematopoietic stem cell ontogeny.
- Zcchc11 Uridylates Mature miRNAs to Enhance Neonatal IGF-1 Expression, Growth, and Survival.
- Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation.
- The promise and perils of stem cell therapeutics.
- Excision of a viral reprogramming cassette by delivery of synthetic cre mRNA.
- Accessing naïve human pluripotency.
- Reprogramming Cellular Identity for Regenerative Medicine.
- Nanog-like Regulates Endoderm Formation through the Mxtx2-Nodal Pathway.
- Erratum: Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells.
- Polycomb repressive complex 2 regulates normal development of the mouse heart.
- Live-cell immunofluorescence staining of human pluripotent stem cells.
- Cell cycle adaptations of embryonic stem cells.
- Induced pluripotent stem cells - opportunities for disease modelling and drug discovery.
- Lineage Regulators Direct BMP and Wnt Pathways to Cell-Specific Programs during Differentiation and Regeneration.
- Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity.
- Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival.
- microRNAs become macro players in somatic cell reprogramming.
- The nomenclature system should be sustainable, but also practical.
- Interactions between Cdx genes and retinoic acid modulate early cardiogenesis.
- Induced pluripotent stem cell models from X-linked adrenoleukodystrophy patients.
- Induced pluripotent stem cells for neural tissue engineering.
- Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells.
- Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome).
- Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells.
- Cellular therapy for fanconi anemia: the past, present, and future.
- Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice.
- Induced pluripotent stem cells: AÂ novel frontier in the study of human primary immunodeficiencies.
- MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states.
- Another horse in the meta-stable state of pluripotency.
- From Hen House to Bedside: Tracing Hanafusa's Legacy from Avian Leukemia Viruses to SRC to ABL and Beyond.
- Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells.
- Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.
- Genomic Approaches to Deconstruct Pluripotency.
- Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.
- Clump passaging and expansion of human embryonic and induced pluripotent stem cells on mouse embryonic fibroblast feeder cells.
- Interaction of retinoic acid and scl controls primitive blood development.
- Reprogramming of T cells from human peripheral blood.
- Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies.
- Robust enhancement of neural differentiation from human ES and iPS cells regardless of their innate difference in differentiation propensity.
- Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells.
- Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage.
- Lin28: A microRNA regulator with a macro role.
- Stem cells: roadmap to the clinic.
- All-trans retinoic acid directs urothelial specification of murine embryonic stem cells via GATA4/6 signaling mechanisms.
- Generation of functional human hepatic endoderm from human induced pluripotent stem cells.
- Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts.
- Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells.
- A robust approach to identifying tissue-specific gene expression regulatory variants using personalized human induced pluripotent stem cells.
- Hematopoietic development from human induced pluripotent stem cells.
- Disease models from pluripotent stem cells.
- 9-(Arenethenyl)purines as dual Src/Abl kinase inhibitors targeting the inactive conformation: design, synthesis, and biological evaluation.
- Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells.
- Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells.
- Lin28 promotes transformation and is associated with advanced human malignancies.
- Upping the ante: recent advances in direct reprogramming.
- Generation of induced pluripotent stem cells from human blood.
- Functional evidence that the self-renewal gene NANOG regulates human tumor development.
- ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines.
- Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming.
- Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells.
- Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration.
- Broader implications of defining standards for the pluripotency of iPSCs.
- Human iPS cell derivation/reprogramming.
- microRNA expression during trophectoderm specification.
- Efficient gene knockdowns in human embryonic stem cells using lentiviral-based RNAi.
- New ISSCR guidelines underscore major principles for responsible translational stem cell research.
- From fibroblasts to iPS cells: induced pluripotency by defined factors.
- Activation of tyrosine kinases by mutation of the gatekeeper threonine.
- Disease-specific induced pluripotent stem cells.
- Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28.
- Ras-MAPK signaling promotes trophectoderm formation from embryonic stem cells and mouse embryos.
- Cdx gene deficiency compromises embryonic hematopoiesis in the mouse.
- Modulation of murine embryonic stem cell-derived CD41+c-kit+ hematopoietic progenitors by ectopic expression of Cdx genes.
Schools
Harvard Medical School
Mass General Hospital
Brigham and Women39sChildren39s
Doctors Specialties
- Hematology
Accepted Insurances
Awards
- Elected Member
- Whos Who in Medicine and Healthcare
- Investigator
Education
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Brigham and Women's Hospital -
Massachusetts General Hospital -
Harvard Medical School
Hospital
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Boston Children's Hospital -
Brigham and Women's Hospital -
Massachusetts General Hospital -
Dana-Farber Cancer Institute
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