Professor, Anesthesia and Perioperative Care, UCSF School of Medicine
Anesthesiology
Dr. James M. Sonner, MD
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James Sonner works in the field of Anesthesiology. He researched medicine at Harvard Medical School. Harvard Medical School is a one of the best medicals schools. Harvard Medical School has a rank of 1 in research and a 12 in primary care He received awards:"CMS Meaningful Use Stage 1 Certification". James M. Sonner is a published doctor as well. He has 96 publications published. The latest was: Ethanol concentrations approaching minimum alveolar anesthetic concentration are required to suppress learning in a fear-potentiated startle paradigm in rats. James Sonner accepts Medicare.
Publications
- 3-hydroxybutyric Acid interacts with lipid monolayers at concentrations that impair consciousness.
- Molecular Mechanisms of Drug Action: An Emerging View.
- Gamma-Aminobutyric Acid Type A Receptor {beta}3 Subunit Forebrain-Specific Knockout Mice Are Resistant to the Amnestic Effect of Isoflurane.
- Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family.
- Conserved role of unc-79 in ethanol responses in lightweight mutant mice.
- Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel.
- Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isoflurane.
- Isovaleric, methylmalonic, and propionic acid decrease anesthetic EC50 in tadpoles, modulate glycine receptor function, and interact with the lipid 1,2-dipalmitoyl-Sn-...
- Tolerance to isoflurane does not occur in developing Xenopus laevis tadpoles.
- Anesthetic-like modulation of receptor function by surfactants: a test of the interfacial theory of anesthesia.
- A hypothesis on the origin and evolution of the response to inhaled anesthetics.
- Is a new paradigm needed to explain how inhaled anesthetics produce immobility?
- Is synergy the rule? A review of anesthetic interactions producing hypnosis and immobility.
- Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats.
- The anesthetic-like effects of diverse compounds on wild-type and mutant gamma-aminobutyric acid type A and glycine receptors.
- Anesthetic properties of the ketone bodies beta-hydroxybutyric acid and acetone.
- Alterations in spinal, but not cerebral, cerebrospinal fluid Na+ concentrations affect the isoflurane minimum alveolar concentration in rats.
- The plasticizer di(2-ethylhexyl) phthalate modulates gamma-aminobutyric acid type A and glycine receptor function.
- Anesthetic-like modulation of a gamma-aminobutyric acid type A, strychnine-sensitive glycine, and N-methyl-d-aspartate receptors by coreleased neurotransmitters.
- Mouse chromosome 7 harbors a quantitative trait locus for isoflurane minimum alveolar concentration.
- Ethnicity can affect anesthetic requirement.
- Anesthetic properties of carbon dioxide in the rat.
- Ammonia has anesthetic properties.
- Lidocaine, MK-801, and MAC.
- Blockade of acetylcholine receptors does not change the dose of etomidate required to produce immobility in rats.
- Determination of the EC50 amnesic concentration of etomidate and its diffusion profile in brain tissue: implications for in vitro studies.
- Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gam...
- Do dopamine receptors mediate part of MAC?
- Chirality in anesthesia II: stereoselective modulation of ion channel function by secondary alcohol enantiomers.
- Chirality in anesthesia I: minimum alveolar concentration of secondary alcohol enantiomers.
- Naloxone does not increase the minimum alveolar anesthetic concentration of sevoflurane in mice.
- The minimum alveolar anesthetic concentration of 2-, 3-, and 4-alcohols and ketones in rats: relevance to anesthetic mechanisms.
- Do N-methyl-D-aspartate receptors mediate the capacity of inhaled anesthetics to suppress the temporal summation that contributes to minimum alveolar concentration?
- Contrasting roles of the N-methyl-D-aspartate receptor in the production of immobilization by conventional and aromatic anesthetics.
- Beta3-containing gamma-aminobutyric acidA receptors are not major targets for the amnesic and immobilizing actions of isoflurane.
- The effect of three inhaled anesthetics in mice harboring mutations in the GluR6 (kainate) receptor gene.
- R (+) etomidate and the photoactivable R (+) azietomidate have comparable anesthetic activity in wild-type mice and comparably decreased activity in mice with a N265M ...
- Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fear.
- Administration of epinephrine does not increase learning of fear to tone in rats anesthetized with isoflurane or desflurane.
- How likely is awareness during anesthesia?
- Thiopental produces immobility primarily by supraspinal actions in rats.
- The effect of meperidine on thermoregulation in mice: involvement of alpha2-adrenoceptors.
- Mice with a melanocortin 1 receptor mutation have a slightly greater minimum alveolar concentration than control mice.
- Gamma-aminobutyric acidA receptors do not mediate the immobility produced by isoflurane.
- Women appear to have the same minimum alveolar concentration as men: a retrospective study.
- Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration.
- Blockade of 5-HT2A receptors may mediate or modulate part of the immobility produced by inhaled anesthetics.
- Temporal summation governs part of the minimum alveolar concentration of isoflurane anesthesia.
- Alpha-2 adrenoreceptors probably do not mediate the immobility produced by inhaled anesthetics.
- Isoflurane antagonizes the capacity of flurothyl or 1,2-dichlorohexafluorocyclobutane to impair fear conditioning to context and tone.
- GABA(A) receptor blockade antagonizes the immobilizing action of propofol but not ketamine or isoflurane in a dose-related manner.
- Spinal N-methyl-d-aspartate receptors may contribute to the immobilizing action of isoflurane.
- Glycine receptors mediate part of the immobility produced by inhaled anesthetics.
- Heteromeric nicotinic inhibition by isoflurane does not mediate MAC or loss of righting reflex.
- Issues in the design and interpretation of minimum alveolar anesthetic concentration (MAC) studies.
- Isoflurane hyperalgesia is modulated by nicotinic inhibition.
- Acetylcholine receptors do not mediate the immobilization produced by inhaled anesthetics.
- Acetylcholine receptors do not mediate isoflurane's actions on spinal cord in vitro.
- Isoflurane causes anterograde but not retrograde amnesia for pavlovian fear conditioning.
- Short-term memory resists the depressant effect of the nonimmobilizer 1-2-dichlorohexafluorocyclobutane (2N) more than long-term memory.
- X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel.
- Knockout of the gene encoding the K(2P) channel KCNK7 does not alter volatile anesthetic sensitivity.
- Hypothermia decreases ethanol MAC in rats.
- Anaesthesia defined (gentlemen, this is no humbug).
- Intrathecal glycine significantly decreases the minimum alveolar concentration of isoflurane in rats.
- Do sevoflurane and desflurane differ in upper airway reactivity?
- Additivity versus synergy: a theoretical analysis of implications for anesthetic mechanisms.
- Halothane and isoflurane have additive minimum alveolar concentration (MAC) effects in rats.
- Transient radicular pain following spinal anesthesia: review of the literature and report of a case involving 2% lidocaine.
- Nonanesthetics can suppress learning.
- Anesthetic and convulsant properties of aromatic compounds and cycloalkanes: implications for mechanisms of narcosis.
- Nephrotoxicity of sevoflurane versus desflurane anesthesia in volunteers.
- Convulsant activity of nonanesthetic gas combinations.
- Anesthetic potencies of n-alkanols: results of additivity and solubility studies suggest a mechanism of action similar to that for conventional inhaled anesthetics.
- Recovery and kinetic characteristics of desflurane and sevoflurane in volunteers after 8-h exposure, including kinetics of degradation products.
- Effects of inhaled nonimmobilizer, proconvulsant compounds on desflurane minimum alveolar anesthetic concentration in rats.
- Desflurane and nitrous oxide, but not nonimmobilizers, affect nociceptive responses.
- Blockade of glutamate receptors and barbiturate anesthesia: increased sensitivity to pentobarbital-induced anesthesia despite reduced inhibition of AMPA receptors in G...
- Nonimmobilizers and transitional compounds may produce convulsions by two mechanisms.
- Both cerebral GABA(A) receptors and spinal GABA(A) receptors modulate the capacity of isoflurane to produce immobility.
- Luciferase as a model for the site of inhaled anesthetic action.
- Inhaled anesthetic responses of recombinant receptors and knockin mice harboring ?2(S270H/L277A) GABA(A) receptor subunits that are resistant to isoflurane.
- Natural Occurrence of Indole-3-acetylaspartate and Indole-3-acetylglutamate in Cucumber Shoot Tissue.
- Relevant concentrations of inhaled anesthetics for in vitro studies of anesthetic mechanisms.
- Hypothesis: volatile anesthetics produce immobility by acting on two sites approximately five carbon atoms apart.
- Mouse strain modestly influences minimum alveolar anesthetic concentration and convulsivity of inhaled compounds.
- Inhaled anesthetics have hyperalgesic effects at 0.1 minimum alveolar anesthetic concentration.
- Naturally occurring variability in anesthetic potency among inbred mouse strains.
- The nonimmobilizer 1,2-dichlorohexafluorocyclobutane does not affect thermoregulation in the rat.
- Neither GABA(A) nor strychnine-sensitive glycine receptors are the sole mediators of MAC for isoflurane.
- Blockade of AMPA receptors and volatile anesthetics: reduced anesthetic requirements in GluR2 null mutant mice for loss of the righting reflex and antinociception but ...
- The concentration of isoflurane required to suppress learning depends on the type of learning.
- Desflurane and the nonimmobilizer 1,2-dichlorohexafluorocyclobutane suppress learning by a mechanism independent of the level of unconditioned stimulation.
- Ethanol concentrations approaching minimum alveolar anesthetic concentration are required to suppress learning in a fear-potentiated startle paradigm in rats.
- Nausea and vomiting following thyroid and parathyroid surgery.
Schools
Harvard Medical School
Uc San Francisco Med Center
Doctors Specialties
- Anesthesiology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
Education
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UCSF -
Harvard Medical School
Hospital
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UCSF Medical Center
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1508819400 |
| Last Name Of The Provider | SONNER |
| First Name Of The Provider | JAMES |
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