Physician
Internal Medicine
Dr. Kenneth Kaushansky, MD
Kenneth Kaushansky is an expert in the field of Internal Medicine. He graduated from David Geffen School of Medicine at UCLA. David Geffen School of Medicine at UCLA is one of the top medical schools in the US. David Geffen School of Medicine at UCLA has a rank of 13 in research and a 7 in primary care He has 2 awards "Elected Member" and "Whos Who in Medicine and Healthcare". Kenneth Kaushansky, MD is also published. He has 101 publications published. The lastest publication: "Megakaryocytic differentiation of HIMeg-1 cells induced by interferon gamma and tumour necrosis factor alpha but not by thrombopoietin.'
Publications
- Obesity-driven disruption of haematopoiesis and the bone marrow niche.
- Phosphorylated c-MPL tyrosine 591 regulates thrombopoietin-induced signaling.
- JAK2V617F-positive endothelial cells contribute to clotting abnormalities in myeloproliferative neoplasms.
- Thrombopoietin from beginning to end.
- Muramyl dipeptide induces production of hemopoietic growth factors in vivo by a mechanism independent of tumor necrosis factor.
- Interleukin-1 alpha also induces granulocyte-macrophage colony-stimulating factor in immature normal bone marrow cells.
- Identification of functionally distinct domains of human granulocyte-macrophage colony-stimulating factor using monoclonal antibodies.
- A neutralizing monoclonal antibody binds to an epitope near the amino terminus of murine granulocyte-macrophage colony-stimulating factor.
- Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro.
- Hematopoietic colony-stimulating factors.
- Role of carbohydrate modification in the production and secretion of human granulocyte macrophage colony-stimulating factor in genetically engineered and normal mesenc...
- A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells.
- In vivo production of interleukin-5, granulocyte-macrophage colony-stimulating factor, macrophages colony-stimulating factor, and interleukin-6 during intravenous admi...
- Hem-1, a potential membrane protein, with expression restricted to blood cells.
- Cytokines in chronic inflammatory arthritis. VI. Analysis of the synovial cells involved in granulocyte-macrophage colony-stimulating factor production and gene expres...
- Mechanisms of cytomegalovirus-mediated myelosuppression: perturbation of stromal cell function versus direct infection of myeloid cells.
- Molecular modeling of human granulocyte-macrophage colony-stimulating factor.
- Transcriptional regulation of interleukin 3 gene expression in T lymphocytes.
- Interleukin 1 stimulates fibroblasts to synthesize granulocyte-macrophage and granulocyte colony-stimulating factors. Mechanism for the hematopoietic response to infla...
- Human fibroblasts produce granulocyte-CSF, macrophage-CSF, and granulocyte-macrophage-CSF following stimulation by interleukin-1 and poly(rI).poly(rC).
- Tumor necrosis factor-alpha and tumor necrosis factor-beta (lymphotoxin) stimulate the production of granulocyte-macrophage colony-stimulating factor, macrophage colon...
- Regulation of differentiation of murine progenitor cells derived from blast cell colonies under serum-deprived conditions.
- Interleukin 1 and poly(rI).poly(rC) induce production of granulocyte CSF, macrophage CSF, and granulocyte-macrophage CSF by human endothelial cells.
- Mechanisms of tumor-induced neutrophilia: constitutive production of colony-stimulating factors and their synergistic actions.
- Interleukin-6 is not involved in the interleukin-1-induced production of colony-stimulating factors by human bone marrow stromal cells and fibroblasts.
- Response of simian virus 40 (SV40)-transformed, cultured human marrow stromal cells to hematopoietic growth factors.
- Hematopoietic activity of granulocyte/macrophage colony-stimulating factor is dependent upon two distinct regions of the molecule: functional analysis based upon the a...
- Cytokines in chronic inflammatory arthritis. II. Granulocyte-macrophage colony-stimulating factor in rheumatoid synovial effusions.
- Interleukin-1 stimulates proliferation of acute myeloblastic leukemia cells by induction of granulocyte-macrophage colony-stimulating factor release.
- Control of granulocyte-macrophage colony-stimulating factor production in normal endothelial cells by positive and negative regulatory elements.
- The role of lymphocytes and monocytes in hematopoietic growth factor production by peripheral blood mononuclear cells.
- Interleukin 1 stimulates human endothelial cells to produce granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor.
- The molecular biology of the colony-stimulating factors.
- Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor.
- Tumor necrosis factor type alpha stimulates human endothelial cells to produce granulocyte/macrophage colony-stimulating factor.
- Role of carbohydrate in the function of human granulocyte-macrophage colony-stimulating factor.
- Chronic destructive arthritis in familial Mediterranean fever: the predominance of hip involvement and its management.
- Inhibitors of topoisomerase II prevent cytokine-induced expression of vascular cell adhesion molecule-1, while augmenting the expression of endothelial leukocyte adhes...
- The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl.
- Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increase...
- Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development.
- The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases.
- Interleukin-4 induces endothelial vascular cell adhesion molecule-1 (VCAM-1) by an NF-kappa b-independent mechanism.
- Murine thrombopoietin mRNA levels are modulated by platelet count.
- Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice.
- Thrombopoietin: the primary regulator of platelet production.
- Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy.
- Thrombopoietin: basic biology, clinical promise.
- The role of protein kinase C in the induction of VCAM-1 expression on human umbilical vein endothelial cells.
- The mpl ligand: molecular and cellular biology of the critical regulator of megakaryocyte development.
- Defining units for thrombopoietin.
- Thrombopoietin, the c-mpl ligand, is a major regulator of platelet production.
- Thrombopoietin from human embryonic kidney cells is the same factor as c-mpl-ligand.
- Molecular biology glossary.
- In vitro characterization of the human recombinant soluble granulocyte-macrophage colony-stimulating factor receptor.
- Recombinant antibodies in bioactive peptide design.
- Mapping of human granulocyte-macrophage-colony-stimulating-factor domains interacting with the human granulocyte-macrophage-colony-stimulating-factor-receptor alpha-su...
- Granulocyte-macrophage colony-stimulating factor expression is regulated at transcriptional and posttranscriptional levels in a murine bone marrow stromal cell line.
- Coordinate regulation of multiple human lymphokine genes by Oct-1 and potentially novel 45 and 43 kDa polypeptides.
- Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo.
- Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin.
- Hematopoietic growth factors: understanding functional diversity in structural terms.
- Transcriptional regulation of interleukin 3 (IL3) in primary human T lymphocytes. Role of AP-1- and octamer-binding proteins in control of IL3 gene expression.
- Thrombopoietin: the primary regulator of megakaryocyte and platelet production.
- Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells.
- Insights into the cellular mechanisms of erythropoietin-thrombopoietin synergy.
- Thrombopoietin: biological and preclinical properties.
- Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic p...
- Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice.
- A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice.
- The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells.
- The regulation of GM-CSF is dependent on a complex interplay of multiple nuclear proteins.
- Structure-function relationships of stem cell factor: an analysis based on a series of human-murine stem cell factor chimera and the mapping of a neutralizing monoclon...
- The thrombocytopenia of cancer. Prospects for effective cytokine therapy.
- Thrombopoietin accelerates platelet, red blood cell, and neutrophil recovery in myelosuppressed mice.
- Thrombopoietin and platelet development.
- Effect of thrombopoietin on the development of megakaryocytes and platelets: an ultrastructural analysis.
- Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 recepto...
- Thrombopoietin: in vitro predictions, in vivo realities.
- Synergistic effects of thrombopoietin and granulocyte colony-stimulating factor on neutrophil recovery in myelosuppressed mice.
- Thrombopoietin and the physiology of platelet production.
- Glossary of molecular biology terminology.
- Thrombopoietin signal transduction in purified murine megakaryocytes.
- Thrombopoietin: understanding and manipulating platelet production.
- Human platelets display high-affinity receptors for thrombopoietin.
- Thrombopoietin is synergistic with other hematopoietic growth factors and physiologic platelet agonists for platelet activation in vitro.
- Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain.
- Thrombopoietin: platelets on demand?
- Thrombopoietin: basic biology and clinical promise.
- Thrombopoietin: more than a lineage-specific megakaryocyte growth factor.
- Structure and function of the cytokine receptor superfamily.
- Physiology and preclinical studies of thrombopoietin.
- Biology of thrombopoietin.
- Thrombopoietin and the hematopoietic stem cell.
- Targeted expansion of genetically modified bone marrow cells.
- Thrombopoietin.
- The role of the MPL receptor in myeloproliferative disorders.
- Secretable human platelet-derived factor V originates from the plasma pool.
- Megakaryocytic differentiation of HIMeg-1 cells induced by interferon gamma and tumour necrosis factor alpha but not by thrombopoietin.
- Thrombopoietin signal transduction: studies from cell lines and primary cells.
Schools
University of California At Los Angeles
University Wa
Doctors Specialties
- Hematology
- Internal Medicine
Accepted Insurances
Awards
- Elected Member
- Whos Who in Medicine and Healthcare
Education
-
University of Washington -
David Geffen School of Medicine at UCLA
Hospital
-
Stony Brook University Medical Center
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