Professor, Medicine, Stony Brook University SOM
Hematology
Dr. Wadie F. Bahou, MD
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Doctor Wadie F. Bahou, MD practices Hematology. He researched medicine at University of Massachusetts Medical School. University of Massachusetts Medical School is ranked 49 in research and 12 in primary care medicine He has 2 awards "Elected Member" and "Fellow (FACP)". Dr. Wadie F. Bahou is a published doctor and has 78 publications published. The lastest was: 'The propeptide domain of membrane type 1 matrix metalloproteinase is required for binding of tissue inhibitor of metalloproteinases and for activation of pro-gelatinas...' He is registered with Medicare and accepts Medicare payments.
Publications
- Genetic Dissection of Platelet Function in Health and Disease Using Systems Biology.
- Platelet genetic biomarker quantification: Comparison of fluorescent microspheres and PCR platforms.
- Protease-activated receptors.
- IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization.
- Transcript profiling of human platelets using microarray and serial analysis of gene expression.
- Genomic signature tags (GSTs): a system for profiling genomic DNA.
- Attacked from within, blood thins.
- The organomercurial 4-aminophenylmercuric acetate, independent of matrix metalloproteinases, induces dose-dependent activation/inhibition of platelet aggregation.
- Expression of protease activated receptor 3 (PAR3) is upregulated by induction of megakaryocyte phenotype in human erythroleukemia (HEL) Cells.
- Proteomics in platelet science.
- Distinct PAR/IQGAP expression patterns during murine development: implications for thrombin-associated cytoskeletal reorganization.
- Platelet transcriptome: the application of microarray analysis to platelets.
- Expression of therapeutic levels of factor VIII in Hemophilia A mice using a novel adeno/adeno-associated hybrid virus.
- A shear-restricted pathway of platelet procoagulant activity is regulated by IQGAP1.
- Distinct roles for the catalytic and hemopexin domains of membrane type 1-matrix metalloproteinase in substrate degradation and Cell migration.
- IQGAP1 is involved in post-ischemic neovascularization by regulating angiogenesis and macrophage infiltration.
- Platelet transcriptome and cardiovascular Disease.
- Class prediction models of Thrombocytosis using genetic biomarkers.
- The platelet proteome.
- Altered bioavailability of platelet-derived factor VIII during Thrombocytosis reverses phenotypic efficacy in haemophilic mice.
- Genomic and proteomic applications in diagnosis of platelet Disorders and classification.
- Multiplexed genetic profiling of human blood platelets using fluorescent microspheres.
- Transcript profiling of human platelets using microarray and serial analysis of gene expression (SAGE).
- Development of hepatoCellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent.
- Proteomic approaches to dissect platelet function: Half the story.
- Platelets express steroidogenic 17beta-hydroxysteroid dehydrogenases. Distinct profiles predict the essential thrombocythemic phenotype.
- ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1.
- Ablation of Iqgap2 protects from diet-induced hepatic steatosis due to impaired fatty acid uptake.
- Computationally designed adeno-associated virus (AAV) Rep 78 is efficiently maintained within an adenovirus vector.
- IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload.
- Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development.
- Molecular characterization of proteolytically activated receptors: insights from the thrombin receptor and proteinase activated receptor-2 (PAR-2) genes.
- Furin Functions as a Nonproteolytic Chaperone for Matrix Metalloproteinase-28: MMP-28 Propeptide Sequence Requirement.
- Mapping the platelet proteome: a report of the ISTH Platelet Physiology Subcommittee.
- Thrombin''s faces revealed: cellular effects include induction of neoangiogenesis.
- A conserved sequence within the propeptide domain of membrane type 1 matrix metalloproteinase is critical for function as an intramolecular chaperone.
- Adeno-associated virus (AAV) Rep protein enhances the generation of a recombinant mini-adenovirus (Ad) utilizing an Ad/AAV hybrid virus.
- The propeptide domain of membrane type 1-matrix metalloproteinase acts as an intramolecular chaperone when expressed in trans with the mature sequence in COS-1 Cells.
- Platelet glycoprotein Ib: a zinc-dependent binding protein for the heavy chain of high-molecular-weight kininogen.
- MSE55, a Cdc42 effector protein, induces long Cellular extensions in fibroblasts.
- The 9-kDa N-terminal propeptide domain of MT1-MMP is required for the activation of progelatinase A.
- Proteolytically activated receptor-3. A member of an emerging gene family of protease receptors expressed on vascular endothelial Cells and platelets.
- Human factor VIII can be packaged and functionally expressed in an adeno-associated virus background: applicability to haemophilia A gene therapy.
- The propeptide domain of membrane type 1 matrix metalloproteinase is required for binding of tissue inhibitor of metalloproteinases and for activation of pro-gelatinas...
- The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a Par gene cluster and characterization in vascular endothelial Cells and platelets.
- Vascular endothelial growth factor induces tissue factor and matrix metalloproteinase production in endothelial Cells: conversion of prothrombin to thrombin results in...
- Characterization of the initial alpha-thrombin interaction with glycoprotein Ib alpha in relation to platelet activation.
- Tissue inhibitor of metalloproteinase-2 (TIMP-2) binds to the catalytic domain of the Cell surface receptor, membrane type 1-matrix metalloproteinase 1 (MT1-MMP).
- The human thrombin receptor gene and the 5q-Syndrome.
- Mitogenic responses mediated through the proteinase-activated receptor-2 are induced by expressed forms of mast Cell alpha- or beta-tryptases.
- Myelodysplasia presenting as monoarthritis.
- The human thrombin receptor and proteinase activated receptor-2 genes are tightly linked on chromosome 5q13.
- Characterization of recombinant adeno-associated virus-2 as a vehicle for gene delivery and expression into vascular Cells.
- In vivo gene transfer into rat arterial walls with novel adeno-associated virus vectors.
- Permissive role of nitric oxide in endothelin-induced migration of endothelial Cells.
- Human monocyte adhesion is modulated by endothelin B receptor-coupled nitric oxide release.
- Membrane type matrix metalloproteinase 1 activates pro-gelatinase A without furin cleavage of the N-terminal domain.
- Antisense oligodeoxynucleotides to inducible NO synthase rescue epithelial Cells from oxidative stress injury.
- Plasmin-platelet interaction involves cleavage of functional thrombin receptor.
- Nitric oxide is necessary for a switch from stationary to locomoting phenotype in epithelial Cells.
- Genomic cloning and characterization of the human thrombin receptor gene. Structural similarity to the proteinase activated receptor-2 gene.
- The thrombin receptor gene is centromeric to the common proximal breakpoint in patients with the 5q- Syndrome: identification of a previously unrecognized chromosome 5...
- The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial Cells.
- Chromosomal assignment of the human thrombin receptor gene: localization to region q13 of chromosome 5.
- The thrombin receptor extraCellular domain contains sites crucial for peptide ligand-induced activation.
- Termination of endothelin signaling: role of nitric oxide.
- Identification of a novel thrombin receptor sequence required for activation-dependent responses.
- The VLA-2 (alpha 2 beta 1) I domain functions as a ligand-specific recognition sequence for endothelial Cell attachment and spreading: molecular and functional charact...
- Mast Cells are potent regulators of endothelial Cell adhesion molecule ICAM-1 and VCAM-1 expression.
- Thrombin induces the activation of progelatinase A in vascular endothelial Cells. Physiologic regulation of angiogenesis.
- Molecular and functional characterization of the non-isopeptide-selective ETB receptor in endothelial Cells. Receptor coupling to nitric oxide synthase.
- Molecular genetic analysis of porcine von Willebrand Disease: tight linkage to the von Willebrand factor locus.
- A monoclonal antibody to von Willebrand factor (vWF) inhibits factor VIII binding. Localization of its antigenic determinant to a nonadecapeptide at the amino terminus...
- Hemonectin: a novel hematopoietic adhesion molecule.
- The molecular defect in type IIB von Willebrand Disease. Identification of four potential missense mutations within the putative GpIb binding domain.
- cDNA cloning and molecular characterization of MSE55, a novel human serum constituent protein that displays bone marrow stromal/endothelial Cell-specific expression.
- Fine mapping of monoclonal antibody epitopes on human von Willebrand factor using a recombinant peptide library.
Schools
University of Massachusetts Worcester Campus
Berkshire Med Center
University Of Michigan
Conditions Treated
- Anemia
- Antiphospholipid Syndrome (APS)
- Coagulation Disorders (incl. Hemophilia)
- Colorectal Cancer
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Doctors Specialties
- Hematology
- Medical Oncology
- Oncology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Blue Card PPO
- Capital District Physician's Health Plan (CDPHP) HMO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Commercial Insurance Company
- Emblem Health
- GHI PPO
- Health Insurance Plan of Greater New York (HIP) PPO
- Empire Blue Cross Blue Shield HMO
- Prism Blue Priority EPO
- Fidelis Care HMO
- HealthFirst
- MagnaCare PPO
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Neighborhood Health Plan
- Freedom Plan
- Oxford Liberty
- United Healthcare
Awards
- Elected Member
- Fellow (FACP)
Education
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University of Massachusetts Medical School
Hospital
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Stony Brook University Medical Center
Drug Facts
| NPI NUMBER | 1891720702 | |
| NPPES Provider LastName | BAHOU | |
| NPPES Provider FirstName | WADIE | |
| NPPES Provider ZIPCode | 11794 | |
| NPPES Provider State | NY | |
| Specialty Description | Hematology | |
| Total Claim Count | 50.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1891720702 |
| Last Name Of The Provider | BAHOU |
| First Name Of The Provider | WADIE |
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