Physician
Pathology
Dr. Laurence J. Marton, MD
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Dr. Laurence J. Marton works in the field of Pathology. He attended Albert Einstein College of Medicine of Yeshiva University. He over the years received 1 awards: "Whos Who in Medicine and Healthcare". Laurence Marton has written publications. He has 101 publications published with PubMed. The lastest paper is: 'Polyamines in malignant melanoma. Urinary excretion and disease progress.'
Publications
- Histone Deacetylase Inhibition Overcomes Drug Resistance through a miRNA-Dependent Mechanism.
- Oligoamine Analogues in Combination with 2-Difluoromethylornithine (DFMO) Synergistically Induce Re-expression of Aberrantly Silenced Tumor Suppressor Genes.
- Subtype and pathway specific responses to anticancer compounds in breast cancer.
- Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells.
- Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes.
- Therapeutic evaluation of polyamine analogue drug candidates against Enterocytozoon bieneusi in a SCID mouse model.
- Blocker protection by short spermine analogs: refined mapping of the spermine binding site in a Kir channel.
- The novel polyamine analogue CGC-11093 enhances the antimyeloma activity of bortezomib.
- Activities of DL-alpha-difluoromethylarginine and polyamine analogues against Cryptosporidium parvum infection in a T-cell receptor alpha-deficient mouse model.
- Leishmania donovani polyamine biosynthetic enzyme overproducers as tools to investigate the mode of action of cytotoxic polyamine analogs.
- Pharmacogenomics of the polyamine analog 3,8,13,18-tetraaza-10,11-[(E)-1,2-cyclopropyl]eicosane tetrahydrochloride, CGC-11093, in the colon adenocarcinoma cell line HC...
- Polyamine analogues down-regulate estrogen receptor alpha expression in human breast cancer cells.
- The polyamine binding site in inward rectifier K+ channels.
- Suppression and regression of choroidal neovascularization by polyamine analogues.
- Role of p53/p21(Waf1/Cip1) in the regulation of polyamine analogue-induced growth inhibition and cell death in human breast cancer cells.
- Macrocyclic polyamines deplete cellular ATP levels and inhibit cell growth in human prostate cancer cells.
- Regulation of polyamine analogue cytotoxicity by c-Jun in human MDA-MB-435 cancer cells.
- Cyclopropane-containing polyamine analogues are efficient growth inhibitors of a human prostate tumor xenograft in nude mice.
- A novel polyamine analog inhibits growth and induces apoptosis in human breast cancer cells.
- Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection.
- Properties of cell cultures containing the citrus exocortis viroid.
- Preproricin expressed in Nicotiana tabacum cells in vitro is fully processed and biologically active.
- Alz-50 immunohistochemistry in the normal sheep striatum: a light and electron microscope study.
- Medical schools are adapting to the future. Interview by Shari Hamilton.
- [Polyamines as biomechanical markers in cancer and polyamine inhibitors efficacy in the treatment of malignant tumors].
- Determination of organic acids in biological fluids by ion chromatography: plasma lactate and pyruvate and urinary vanillylmandelic acid.
- Effects of the polyamine analogues BE-4-4-4-4, BE-3-7-3, and BE-3-3-3 on the proliferation of three prostate cancer cell lines.
- The ability of polyamine analogues to induce Z-DNA structure in synthetic polynucleotides in vitro inversely correlates with their effects on cytotoxicity of cis-diami...
- Treatment with a polyamine analog alters DNA-matrix association in HeLa cell nuclei: a nucleoid halo assay.
- Differential effects of spermine and its analogues on the structures of polynucleotides complexed with ethidium bromide.
- Effects of fractionated radiation therapy on human brain tumor multicellular spheroids.
- Interaction of a polyamine analogue, 1,19-bis-(ethylamino)-5,10,15- triazanonadecane (BE-4-4-4-4), with DNA and effect on growth, survival, and polyamine levels in sev...
- The effects of O6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells.
- Effects of the polyamine analogs BE-3-7-3, 3-8-3, and BE-3-8-3 on human brain tumor cell growth and survival.
- Radiation brain injury is reduced by the polyamine inhibitor alpha-difluoromethylornithine.
- Radiopotentiation of human brain tumor cells by the spermine analog N1,N14-bis(ethyl)homospermine.
- Effect of 1,19-bis(ethylamino)-5,10,15-triazanonadecane on human tumor xenografts.
- Design and testing of novel cytotoxic polyamine analogues.
- Brain Tumor Working Group Report on the 9th International Conference on Brain Tumor Research and Therapy. Organ System Program, National Cancer Institute.
- Pretreatment with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) inhibits etoposide cytotoxicity in U-251 MG (NCI) human brain tumor ...
- Slowing proliferation in head and neck tumors: in vitro growth inhibitory effects of the polyamine analog BE-4-4-4-4 in human squamous cell carcinomas.
- The structure of polyamine analogues determines haemoglobin production and cytotoxicity in murine erythroleukaemia cells.
- Spermine induces haemoglobin synthesis in murine erythroleukaemia cells.
- Two polyamine analogs (BE-4-4-4 and BE-4-4-4-4) directly affect growth, survival, and cell cycle progression in two human brain tumor cell lines.
- Polyamines as targets for therapeutic intervention.
- A new model for disruption of the ornithine decarboxylase gene, SPE1, in Saccharomyces cerevisiae exhibits growth arrest and genetic instability at the MAT locus.
- Fluorometric liquid-chromatographic determination of serum cortisol.
- CSF putrescine levels. The enzymatic-isotopic method vs liquid chromatography.
- Measurement of bilirubin and its monoconjugates and diconjugates in human serum by alkaline methanolysis and high-performance liquid chromatography.
- Some comments on anticonvulsant-drug monitoring by liquid chromatography.
- Effects of DL-alpha-methylornithine on proliferation and polyamine content of 9L rat brain tumor cells.
- Simultaneous liquid-chromatographic determination of zinc protoporphyrin IX, protoporphyrin IX, and coproporphyrin in whole blood.
- Polyamines: relation to brain tumor therapy and monitoring.
- Rapid method for screening toxic drugs in serum with liquid chromatography.
- Putrescine diffusion in cat brain and capillary permeability in rat brain: relation to CSF putrescine levels in brain tumor patients.
- Liquid-chromatographic determination of antidysrhythmic drugs: procainamide, lidocaine, quinidine, disopyramide, and propranolol.
- Simultaneous liquid chromatographic analysis of amitriptyline, nortriptyline, imipramine, desipramine, doxepin, and nordoxepin.
- CSF polyamines: a new and important means of monitoring patients with medulloblastoma.
- Further evidence for the use of polyamines as biochemical markers for malignant tumors.
- Polyamine levels in CSF from patients with pituitary tumors or nonneoplastic pituitary disease.
- Liquid chromatography with fluorometric detection of unconjugated estriol in serum of pregnant women.
- Liquid-chromatographic determination of tobramycin in serum with spectrophotometric detection.
- CSF polyamines in childhood.
- Simultaneous very fast liquid-chromatographic analysis of ethosuximide, primidone, phenobarbital, phenytoin, and carbamazepine in serum.
- Polyamine depletion influences drug-induced chromosomal damage.
- Liquid-chromatographic analysis for serum theophylline in less than 70 seconds.
- An approach to the use of polyamine inhibitors for cancer therapy.
- Decreased cytotoxicity of cis-diamminedichloroplatinum(II) by alpha-difluoromethylornithine depletion of polyamines in 9L rat brain tumor cells in vitro.
- Potentiation of the antitumor therapeutic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor.
- Sensitization of 9L rat brain gliosarcoma cells to 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor.
- Depletion of 9L rat brain tumor cell polyamine content by treatment with D,L-alpha-difluoromethylornithine inhibits proliferation and the G1 to S transition.
- Depletion of intracellular polyamine content does not alter the survival of 9L rat brain tumour cells after X-irradiation.
- Age-related abnormalities of circulating polyamines and diamine oxidase activity in cystic fibrosis heterozygotes and homozygotes.
- Ornithine decarboxylase is important in intestinal mucosal maturation and recovery from injury in rats.
- Polyamines. The elusive cancer markers.
- alpha-Difluoromethylornithine alters calcium signaling in platelet-derived growth factor-stimulated A172 brain tumor cells in culture.
- Polyamine depletion and drug-induced chromosomal damage: new results.
- Production of stable phenotypes from 9L rat brain tumor multicellular spheroids treated with 1,3-bis(2-chloroethyl)-1-nitrosourea.
- Determination of carbamazepine in blood or plasma by high-pressure liquid chromatography.
- Simultaneous measurement of phenobarbital, diphenylhydantoin, and primidone in blood by high-pressure liquid chromatography.
- The relationship of polyamines in cerebrospinal fluid to the presence of central nervous system tumors.
- Polyamine metabolism in a rat brain tumor cell line: its relationship to the growth rate.
- More sensitive automated detection of polyamines in physiological fluids and tissue extracts with omicron-phthalaldehyde.
- Changes in polyamine metabolism in WI38 cells stimulated to proliferate.
- Polyamines: a high correlation with cell replication.
- Polyamines in malignant melanoma. Urinary excretion and disease progress.
- High-pressure liquid-chromatographic determination of 5-(4-hydroxyphenyl)-5-phenylhydantoin in humanurine.
- Changes in L-ornithine decarboxylase activity during the cell cycle.
- Effect of methylglyoxal-bis (guanylhydrazone), an inhibitor of spermidine and spermine synthesis, on cell cycle traverse.
- Determination of acetaminophen and phenacetin in plasma by high-pressure liquid chromatography.
- Determination of placental estriol in urine by gas-liquid chromatography, with equilenin as internal standard.
- Measurement of lactate extraction ratio by centrifugal analyzer to assess myocardial ischemia.
- Uremic polyamine dysmetabolism.
- Biochemical markers of central nervous system tumors in cerebrospinal fluid.
- Improved liquid chromatographic determination of placental estriol in urine.
- Source of error in cerebrospinal fluid protein determination with the Du Pont Automatic Clinical Analyzer.
- Separation of polyamines by polyacrylamide gel exchange chromatography.
- Improved liquid-chromatographic method for determination of serum cortisol.
- Depletion of intracellular putrescine and spermidine by alpha-difluromethylornithine does not inhibit proliferation of 9L rat brain tumor cells.
- Predictive value of cerebrospinal fluid polyamines in medulloblastoma.
Schools
Albert Einstein College of Medicine of Yeshiva University
Doctors Specialties
- Clinical Pathology
- Pathology
Accepted Insurances
Awards
- Whos Who in Medicine and Healthcare
Education
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UCSF -
Harbor - UCLA Medical Center -
Albert Einstein College of Medicine of Yeshiva University
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