Professor, Medicine, Stony Brook University SOM
Hematology
Dr. Yusuf A. Hannun, MD
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Dr. Yusuf A. Hannun is an expert in the field of Hematology. He received 1 awards: "Elected Member". Yusuf Hannun is a published doctor and has 100 publications published. The lastest was: 'Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death.'
Publications
- Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.
- Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase.
- GPR40/FFA1 and neutral sphingomyelinase are involved in palmitate-boosted inflammatory response of microvascular endothelial cells to LPS.
- A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma.
- Targeting (cellular) lysosomal acid ceramidase by B13: Design, synthesis and evaluation of novel DMG-B13 ester prodrugs.
- Critical determinants of mitochondria-associated neutral sphingomyelinase (MA-nSMase) for mitochondrial localization.
- Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis.
- Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes.
- Ceramide and sphingosine-1-phosphate act as photodynamic therapy-elicited damage-associated molecular patterns: Cell surface exposure.
- Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.
- Evolving concepts in cancer therapy through targeting sphingolipid metabolism.
- Sphingolipid signaling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1.
- The yeast sphingolipid signaling landscape.
- Sustained PKCβII activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner.
- Sphingolipids in colon cancer.
- Sphingosine Kinase 1 Regulates Tumor Necrosis Factor-mediated RANTES Induction through p38 Mitogen-activated Protein Kinase but Independently of Nuclear Factor κB Acti...
- Acid Sphingomyelinase Plays a Key Role in Palmitic Acid-Amplified Inflammatory Signaling Triggered by Lipopolysaccharide at Low Concentration in Macrophages.
- Sphingosine-1-phosphate receptor 2.
- Sphingolipid regulation of ezrin, radixin, and moesin proteins family: Implications for cell dynamics.
- Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis.
- Adiponectin Regulates Bone Mass via Opposite Central and Peripheral Mechanisms through FoxO1.
- Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation.
- Effect of sphingosine kinase 1 inhibition on blood pressure.
- Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins.
- Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease.
- Identification and Characterization of PP2C Activation by Ceramide.
- Off-Target Function of the Sonic-Hedgehog Inhibitor Cyclopamine in Mediating Apoptosis via Nitric Oxide-Dependent Neutral Sphingomyelinase 2/Ceramide Induction.
- Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized LDL and oxidized LDL immune complexes: role in phagocytosis and cytokine release.
- The Roles of Neutral Sphingomyelinases in Neurological Pathologies.
- Cellular Morphogenesis under Stress is Influenced by the Sphingolipid Pathway Gene ISC1 and DNA Integrity Checkpoint Genes in Saccharomyces cerevisiae.
- Results of a Phase II Trial of Gemcitabine Plus Doxorubicin in Patients with Recurrent Head and Neck Cancers: Serum C18-Ceramide as a Novel Biomarker for Monitoring Re...
- A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization.
- Many Ceramides.
- Neutral Sphingomyelinase-2 Mediates Growth Arrest by Retinoic Acid through Modulation of Ribosomal S6 Kinase.
- Delayed Phosphorylation of Classical Protein Kinase C (PKC) Substrates Requires PKC Internalization and Formation of the Pericentrion in a Phospholipase D (PLD)-depend...
- Novel pathway of ceramide production in mitochondria: Thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-COA.
- Identification of novel anionic phospholipid binding domains in neutral sphingomyelinase 2 with selective binding preference.
- Ceramide Synthase-dependent Ceramide Generation and Programmed Cell Death: INVOLVEMENT OF SALVAGE PATHWAY IN REGULATING POSTMITOCHONDRIAL EVENTS.
- Identification of Dihydroceramide Desaturase as a Direct in vitro target for Fenretinide.
- A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation.
- Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase.
- Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine.
- A role of sphingosine kinase 1 in head and neck carcinogenesis.
- Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-α in MCF-7 cells.
- A novel mechanism of lysosomal acid sphingomyelinase maturation: requirement for carboxyl-terminal proteolytic processing.
- Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis.
- Accumulation of Long-Chain Glycosphingolipids during Aging Is Prevented by Caloric Restriction.
- Mathematical Modeling and Validation of the Ergosterol Pathway in Saccharomyces cerevisiae.
- Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells.
- Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism.
- Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse.
- Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses.
- Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation.
- Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane.
- Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB.
- Blood sphingolipidomics in healthy humans: impact of sample collection methodology.
- Identification and characterization of murine mitochondria-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5.
- The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase.
- An overview of sphingolipid metabolism: from synthesis to breakdown.
- Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways.
- Computational analysis of sphingolipid pathway systems.
- AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells.
- The Acid Sphingomyelinase/Ceramide Pathway: Biomedical Significance and Mechanisms of Regulation.
- Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis.
- Sustained receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner.
- Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome.
- Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism.
- Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation.
- Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid.
- ISC1-dependent metabolic adaptation reveals an indispensable role for mitochondria in induction of nuclear genes during the diauxic shift in Saccharomyces cerevisiae.
- Bioactive sphingolipids: metabolism and function.
- Sphingolipids function as downstream effectors of a fungal PAQR.
- Hydroxyurea sensitivity reveals a role for ISC1 in the regulation of G2/M.
- Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer.
- Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling.
- Role for sphingosine kinase 1 in colon carcinogenesis.
- A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis.
- Ceramide-enriched membrane domains in red blood cells and the mechanism of sphingomyelinase-induced hot-cold hemolysis.
- Integrin-associated Lyn kinase promotes cell survival by suppressing acid sphingomyelinase activity.
- Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells.
- Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells.
- De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation.
- Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells.
- Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1.
- Thematic review series: sphingolipids. ISC1 (inositol phosphosphingolipid-phospholipase C), the yeast homologue of neutral sphingomyelinases.
- Dynamics of Positional Enrichment: Theoretical Development and Application to Carbon Labeling in Zymomonas mobilis.
- Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway.
- Acid ceramidase inhibition: a novel target for cancer therapy.
- A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury.
- The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy.
- Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphory...
- Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy.
- Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells.
- Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis.
- Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation.
- Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway.
- Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization.
- Redox regulation of neutral sphingomyelinase-1 activity in HEK293 cells through a GSH-dependent mechanism.
- Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death.
Doctors Specialties
- Hematology
Accepted Insurances
Awards
- Elected Member
Education
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Duke University Hospital -
American University of Beirut Faculty of Medicine
Hospital
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Stony Brook University Medical Center
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